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Emerging Therapeutics

Section edited by Gennaro Ciliberto

© Parilov / stock.adobe.comThe Emerging Therapeutics section is dedicated to the wave of emerging therapeutics arising from the intense research efforts and therapeutic breakthroughs based on recent scientific and technological developments. 

The section is interested in original papers, reviews and perspectives on the advancements in the field, including genetic vaccines, monoclonal antibodies, CAR-Ts, gene therapy with viral vectors, clinical applications of CRISPR/CAS9 gene editing, microbiota-modulating approaches, ‘omics approaches, emerging therapeutics from the development of new technologies for drug development, and discovery of new intervention targets and the possibility for new drug combinations.

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  1. JAK-STAT signalling pathway inhibitors have emerged as promising therapeutic agents for the treatment of hair loss. Among different JAK isoforms, JAK3 has become an ideal target for drug discovery because it o...

    Authors: Md Mehedi Hossain, Arfan Khalid, Zaheen Akhter, Sabra Parveen, Mir Owais Ayaz, Aadil Qadir Bhat, Neetu Badesra, Farheen Showket, Mohmmad Saleem Dar, Farhan Ahmed, Sumit Dhiman, Mukesh Kumar, Umed Singh, Razak Hussain, Pankaj Keshari, Ghulam Mustafa…
    Citation: Journal of Translational Medicine 2024 22:370
    Content type: Research Published on:

  2. HER3 (ErbB3), a member of the human epidermal growth factor receptor family, is frequently overexpressed in various cancers. Multiple HER3-targeting antibodies and antibody–drug conjugates (ADCs) were develope...

    Authors: Xi Li, Jun Yao, Chen Qu, Lan Luo, Bing Li, Yu Zhang, Zhongyuan Zhu, Yang Qiu and Haiqing Hua
    Citation: Journal of Translational Medicine 2024 22:362
    Content type: Research Published on:

  3. Targeting CD47/SIRPα axis has emerged as a promising strategy in cancer immunotherapy. Despite the encouraging clinical efficacy observed in hematologic malignancies through CD47-SIRPα blockade, there are safe...

    Authors: Tao Wang, Si-Qin Wang, Yin-Xiao Du, Dan-Dan Sun, Chang Liu, Shuang Liu, Ying-Ying Sun, Hai-Long Wang, Chun-Sheng Zhang, Hai-Long Liu, Lei Jin and Xiao-Ping Chen
    Citation: Journal of Translational Medicine 2024 22:220
    Content type: Research Published on:

  4. First identified in Drosophila melanogaster, the Hippo pathway is considered a major regulatory cascade controlling tissue homeostasis and organ development. Hippo signaling components include kinases whose activ...

    Authors: Giulia Schiavoni, Beatrice Messina, Stefano Scalera, Lorenzo Memeo, Cristina Colarossi, Marzia Mare, Giovanni Blandino, Gennaro Ciliberto, Giulia Bon and Marcello Maugeri-Saccà
    Citation: Journal of Translational Medicine 2024 22:213
    Content type: Review Published on:

  5. Zinc finger SWIM-type containing 4 (ZSWIM4) induces drug resistance in breast cancer cells. However, its role in epithelial ovarian cancer (EOC) remains unknown. In this study, we aimed to investigate the clin...

    Authors: Kunxiang Gong, Yinger Huang, Yanqin Zheng, Wenbo Hao and Kun Shi
    Citation: Journal of Translational Medicine 2024 22:192
    Content type: Research Published on:

  6. Lung cancer, a prevalent and aggressive disease, is characterized by recurrence and drug resistance. It is essential to comprehend the fundamental processes and discover novel therapeutic objectives for augmen...

    Authors: Ailing Wang, Wei-sha Zheng, Zhen Luo, Lian Bai and Shi Zhang
    Citation: Journal of Translational Medicine 2024 22:173
    Content type: Research Published on:

  7. Neuroblastoma (NB) represents the most frequent and aggressive form of extracranial solid tumor of infants. Although the overall survival of patients with NB has improved in the last years, more than 50% of hi...

    Authors: Mario Capasso, Chiara Brignole, Vito A. Lasorsa, Veronica Bensa, Sueva Cantalupo, Enrico Sebastiani, Alessandro Quattrone, Eleonora Ciampi, Marianna Avitabile, Angela R. Sementa, Katia Mazzocco, Barbara Cafferata, Gabriele Gaggero, Valerio G. Vellone, Michele Cilli, Enzo Calarco…
    Citation: Journal of Translational Medicine 2024 22:151
    Content type: Research Published on:

  8. The current precision medicine relies on biomarkers, which are mainly obtained through next-generation sequencing (NGS). However, this model failed to find effective drugs for most cancer patients. This study ...

    Authors: Huan Yang, Xing Xiao, Leli Zeng, Haiteng Zeng, Yueyuan Zheng, Jingshu Wang, Guanghua Li, Weigang Dai, Yulong He, Suihai Wang, Jianjun Peng and Wei Chen
    Citation: Journal of Translational Medicine 2024 22:132
    Content type: Research Published on:

  9. Immune checkpoint blockades have been prized in circumventing and ablating the impediments posed by immunosuppressive receptors, reaching an exciting juncture to be an innovator in anticancer therapy beyond tr...

    Authors: Siyuan Wang, Jiaxin Wang, Yu Xia, Le Zhang, Yueqiang Jiang, Man Liu, Qinglei Gao and Cuntai Zhang
    Citation: Journal of Translational Medicine 2024 22:130
    Content type: Review Published on:

  10. While antibiotics remain our primary tools against microbial infection, increasing antibiotic resistance (inherent and acquired) is a major detriment to their efficacy. A practical approach to maintaining or r...

    Authors: Amita Sekar, Dmitry Gil, Peyton Tierney, Madeline McCanne, Vikram Daesety, Darina Trendafilova, Orhun K. Muratoglu and Ebru Oral
    Citation: Journal of Translational Medicine 2024 22:102
    Content type: Research Published on:

  11. The extracellular matrix (ECM) plays critical roles in cytoskeletal support, biomechanical transduction and biochemical signal transformation. Tumor-associated macrophage (TAM) function is regulated by matrix ...

    Authors: Jiaqiang Xiong, Rourou Xiao, Jiahui Zhao, Qiuyan Zhao, Manwen Luo, Feng Li, Wei Zhang and Meng Wu
    Citation: Journal of Translational Medicine 2024 22:85
    Content type: Review Published on:

  12. The main challenge in personalized treatment of breast cancer (BC) is how to integrate massive amounts of computing resources and data. This study aimed to identify a novel molecular target that might be effec...

    Authors: Qinan Yin, Haodi Ma, Yirui Dong, Shunshun Zhang, Junxiang Wang, Jing Liang, Longfei Mao, Li Zeng, Xin Xiong, Xingang Chen, Jingjing Wang and Xuewei Zheng
    Citation: Journal of Translational Medicine 2024 22:84
    Content type: Research Published on:

  13. Osteosarcoma is the most common malignant primary bone tumor in infants and adolescents. The lack of understanding of the molecular mechanisms underlying osteosarcoma progression and metastasis has contributed...

    Authors: Weidong Chen, Yan Liao, Pengxiao Sun, Jian Tu, Yutong Zou, Ji Fang, Ziyun Chen, Hongbo Li, Junkai Chen, Yuzhong Peng, Lili Wen and Xianbiao Xie
    Citation: Journal of Translational Medicine 2024 22:66
    Content type: Research Published on:

  14. The alkaloid camptothecin analog SN38 is a potent antineoplastic agent, but cannot be used directly for clinical application due to its poor water solubility. Currently, the prodrug approach on SN38 has result...

    Authors: Changjun Yu, Faqing Huang, Kinsley Wang, Mengmeng Liu, Warren A. Chow, Xiang Ling, Fengzhi Li, Jason L. Causey, Xiuzhen Huang, Galen Cook-Wiens and Xiaojiang Cui
    Citation: Journal of Translational Medicine 2023 21:897
    Content type: Research Published on:

  15. Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancers with a very low survival rate at 5 years. The use of chemotherapeutic agents results in only modest prolongation of survival and is...

    Authors: Davide Busato, Sara Capolla, Paolo Durigutto, Monica Mossenta, Sara Bozzer, Daniele Sblattero, Paolo Macor, Michele Dal Bo and Giuseppe Toffoli
    Citation: Journal of Translational Medicine 2023 21:864
    Content type: Research Published on:

  16. Skin cutaneous melanoma (SKCM) is the most aggressive skin cancer, accounting for more than 75% mortality rate of skin-related cancers. As a newly identified programmed cell death, pyroptosis has been found to...

    Authors: Shixin Zhao, Yongkang Zhu, Hengdeng Liu, Xuefeng He and Julin Xie
    Citation: Journal of Translational Medicine 2023 21:801
    Content type: Research Published on:

  18. Molecular Tumor Boards (MTB) operating in real-world have generated limited consensus on good practices for accrual, actionable alteration mapping, and outcome metrics. These topics are addressed herein in 124...

    Authors: Patrizio Giacomini, Fabio Valenti, Matteo Allegretti, Matteo Pallocca, Francesca De Nicola, Ludovica Ciuffreda, Maurizio Fanciulli, Stefano Scalera, Simonetta Buglioni, Elisa Melucci, Beatrice Casini, Mariantonia Carosi, Edoardo Pescarmona, Elena Giordani, Francesca Sperati, Nicoletta Jannitti…
    Citation: Journal of Translational Medicine 2023 21:725
    Content type: Research Published on:

  19. Clear cell renal cell carcinoma (ccRCC) is closely associated with steroid hormones and their receptors affected by lipid metabolism. Recently, there has been growing interest in the carcinogenic role of NR3C1...

    Authors: Minbo Yan, Jinhua Wang, Haojie Wang, Jun Zhou, Hao Qi, Yaser Naji, Liangyu Zhao, Yuxin Tang and Yingbo Dai
    Citation: Journal of Translational Medicine 2023 21:701
    Content type: Research Published on:

  20. Antibody technology is widely used in the fields of biomedical and clinical therapies. Nonetheless, the complex in vitro expression of recombinant proteins, long production cycles, and harsh storage conditions...

    Authors: Yuxiang Zhao, Linchuan Gan, Dangjin Ke, Qi Chen and Yajuan Fu
    Citation: Journal of Translational Medicine 2023 21:693
    Content type: Review Published on:

  21. Distant metastasis remains a leading cause of mortality among patients with colorectal cancer (CRC). Organotropism, referring to the propensity of metastasis to target specific organs, is a well-documented phe...

    Authors: Kai He, Zhihan Wang, Maochao Luo, Bowen Li, Ning Ding, Lei Li, Bo He, Han Wang, Jiangjun Cao, Canhua Huang, Jun Yang and Hai-Ning Chen
    Citation: Journal of Translational Medicine 2023 21:612
    Content type: Review Published on:

  22. Recurrent or metastatic cervical cancer (r/m CC) often has poor prognosis owing to its limited treatment options. The development of novel therapeutic strategies has been hindered by the lack of preclinical mo...

    Authors: Liting Liu, Min Wu, Anni Huang, Chun Gao, Yifan Yang, Hong Liu, Han Jiang, Long Yu, Yafei Huang and Hui Wang
    Citation: Journal of Translational Medicine 2023 21:611
    Content type: Research Published on:

  23. Neuroblastoma (NB) and pheochromocytoma/paraganglioma (PHEO/PGL) are neuroendocrine tumors. Imaging of these neoplasms is performed by scintigraphy after injection of radiolabeled meta-iodobenzylguanidine (mIBG),...

    Authors: Joana Grand-Guillaume, Rosalba Mansi, Raghuvir H. Gaonkar, Sandra Zanger, Melpomeni Fani, Philippe J. Eugster, Maja Beck Popovic, Eric Grouzmann and Karim Abid
    Citation: Journal of Translational Medicine 2023 21:604
    Content type: Research Published on:

  24. Triple negative breast cancer (TNBC) is a major subtype of breast cancer, with limited therapeutic drugs in clinical. Epidermal growth factor receptor (EGFR) is reported to be overexpressed in various TNBC cel...

    Authors: Tianfeng Yang, Runze Yu, Cheng Cheng, Jian Huo, Zhengyan Gong, Hanbing Cao, Yu Hu, Bingling Dai and Yanmin Zhang
    Citation: Journal of Translational Medicine 2023 21:597
    Content type: Research Published on:

  25. As the most lethal gynecologic cancer, ovarian cancer (OV) holds the potential of being immunotherapy-responsive. However, only modest therapeutic effects have been achieved by immunotherapies such as immune c...

    Authors: Dong Yang, Mei-Han Duan, Qiu-Er Yuan, Zhi-Ling Li, Chuang-Hua Luo, Lan-Yue Cui, Li-Chao Li, Ying Xiao, Xian-Ying Zhu, Hai-Liang Zhang, Gong-Kan Feng, Guo-Chen Liu, Rong Deng, Jun-Dong Li and Xiao-Feng Zhu
    Citation: Journal of Translational Medicine 2023 21:586
    Content type: Research Published on:

  26. Janus kinase 1 (JAK1) plays a critical role in most cytokine-mediated inflammatory, autoimmune responses and various cancers via the JAK/STAT signaling pathway. Inhibition of JAK1 is therefore an attractive th...

    Authors: Zixiao Wang, Lili Sun, Yu Xu, Peida Liang, Kaiyan Xu and Jing Huang
    Citation: Journal of Translational Medicine 2023 21:579
    Content type: Research Published on:

  27. Immunotoxins are antibody-toxin conjugates that bind to surface antigens and exert effective cytotoxic activity after internalization into tumor cells. Immunotoxins exhibit effective cytotoxicity and have been...

    Authors: Xiaoyu Liu, Qingqing Tan, Jiaqi Wen, Xufei Wang, Gang Yang, Yuxiao Li, Ming Lu, Wei Ye, Anfeng Si, Sujuan Ma, Tong Ding, Luan Sun, Fang Liu, Mei Zhang, Tao Jiang and Wei Gao
    Citation: Journal of Translational Medicine 2023 21:572
    Content type: Research Published on:

  28. Triple-negative breast cancer (TNBC) is one of the most aggressive human cancers and has poor prognosis. Approximately 80% of TNBC cases belong to the molecular basal-like subtype, which can be exploited thera...

    Authors: Jie Lei, Yujia Pan, Rui Gao, Bin He, Zifeng Wang, Xinxing Lei, Zijian Zhang, Na Yang and Min Yan
    Citation: Journal of Translational Medicine 2023 21:553
    Content type: Research Published on:

  29. Bladder cancer is a urological carcinoma with high incidence, among which muscle invasive bladder cancer (MIBC) is a malignant carcinoma with high mortality. There is an urgent need to develop new drugs with l...

    Authors: Ruijiao Chen, Xiaopeng Hao, Jingyuan Chen, Changyue Zhang, Huixia Fan, Fuming Lian, Xiaochuan Chen, Chao Wang and Yong Xia
    Citation: Journal of Translational Medicine 2023 21:549
    Content type: Research Published on:

  30. Circular RNA (circRNA) is a type of non-coding RNA that forms a covalently closed, uninterrupted loop. The expression of circRNA differs among cell types and tissues, and various circRNAs are aberrantly expres...

    Authors: Qian Yi, Jiaji Yue, Yang Liu, Houyin Shi, Wei Sun, Jianguo Feng and Weichao Sun
    Citation: Journal of Translational Medicine 2023 21:516
    Content type: Review Published on:

  31. Colorectal cancer (CRC) is highly prevalent and lethal globally, and its prognosis remains unsatisfactory. Drug resistance is regarded as the main cause of treatment failure leading to tumor recurrence and met...

    Authors: Kuei-Yen Tsai, Yu-Jia Chang, Chien-Yu Huang, G. M. Shazzad Hossain Prince, Hsin-An Chen, Precious Takondwa Makondi, Ying-Rou Shen and Po-Li Wei
    Citation: Journal of Translational Medicine 2023 21:505
    Content type: Research Published on:

  32. Ovarian cancer (OC) is the most lethal malignant gynecological tumor type for which limited therapeutic targets and drugs are available. Enhanced mitochondrial oxidative phosphorylation (OXPHOS), which enables...

    Authors: Ruibin Jiang, Zhongjian Chen, Maowei Ni, Xia Li, Hangjie Ying, Jianguo Fen, Danying Wan, Chanjuan Peng, Wei Zhou and Linhui Gu
    Citation: Journal of Translational Medicine 2023 21:504
    Content type: Research Published on:

  33. Small cell lung cancer (SCLC) is a recalcitrant malignancy with elusive mechanism of pathogenesis and dismal prognosis. Over the past decades, platinum-based chemotherapy has been the backbone treatment for SC...

    Authors: Chenyue Zhang, Chenxing Zhang, Kai Wang and Haiyong Wang
    Citation: Journal of Translational Medicine 2023 21:468
    Content type: Review Published on:

  35. Irinotecan (CPT-11) is a classic chemotherapeutic agent that plays an important role in the clinical treatment of metastatic colon cancer and other malignant tumors. We previously designed a series of novel ir...

    Authors: Yongqi Li, Dawei Zhao, Wenqiu Zhang, Miaomiao Yang, Zhihui Wu, Weiguo Shi, Shijie Lan, Zhen Guo, Hong Yu and Di Wu
    Citation: Journal of Translational Medicine 2023 21:422
    Content type: Research Published on:

  36. Recent studies have discovered an emerging role of IL11 in various colitis-associated cancers, suggesting that IL11 mainly promotes tumor cell survival and proliferation in regulating tumorigenesis. Herein we ...

    Authors: Wenjun Xiong, Yuehong Chen, Chaoting Zhang, Jin Li, Haipeng Huang, Yu Zhu, Guangxu Deng, Junhong Cheng, Yixiong Lin, Zhimin Shi and Tingyu Mou
    Citation: Journal of Translational Medicine 2023 21:416
    Content type: Research Published on:

  38. Thyroid-associated ophthalmopathy (TAO) is the most common autoimmune inflammatory diseases of the orbit. The CD40-CD40L pathway has been regarded as a potential molecular mechanism contributing to the develop...

    Authors: Yizhi Chen, Renhong Tang, Wei Xiong, Feng Zhang, Nuo Wang, Bingyu Xie, Jiamin Cao, Zhuokun Chen and Chen Ma
    Citation: Journal of Translational Medicine 2023 21:396
    Content type: Research Published on:

  39. Bispecific antibody has garnered considerable attention in the recent years due to its impressive preliminary efficacy in hematological malignancies. For solid tumors, however, the main hindrance is the suppre...

    Authors: Po-Lin Huang, Hung-Tsai Kan, Ching-Hsuan Hsu, Hsin-Ta Hsieh, Wan-Chien Cheng, Ren-Yeong Huang and Jhong-Jhe You
    Citation: Journal of Translational Medicine 2023 21:346
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Translational Medicine 2023 21:550

  40. More than half of the colorectal cancer (CRC) patients will develop liver metastasis that underlies the cancer mortality. In the hepatic tumor microenvironment, the interplay between CRC cells and hepatic stel...

    Authors: Xueying Fan, Mingjing Meng, Baoting Li, Hui Chen, Jincheng Tan, Keyang Xu, Shilin Xiao, Hiu-Yee Kwan, Zhongqiu Liu and Tao Su
    Citation: Journal of Translational Medicine 2023 21:260
    Content type: Research Published on:

  42. Cancer associated fibroblasts (CAFs) communicate metabolically with tumor genesis and development. Rocuronium bromide (RB) is reported to exert certain inhibitory effect on tumor. Here, we investigate the role...

    Authors: Jingyi Li, Xuefeng Gu, Guoqing Wan, Yuhan Wang, Kaijie Chen, Qi Chen and Changlian Lu
    Citation: Journal of Translational Medicine 2023 21:248
    Content type: Research Published on:

  43. Endometrial cancer (EC) is one of the most common gynecological malignancies globally, and the development of innovative, effective drugs against EC remains a key issue. Phytoestrogen kaempferol exhibits anti-...

    Authors: Guan-Yu Ruan, Li-Xiang Ye, Jian-Song Lin, Hong-Yu Lin, Li-Rui Yu, Cheng-Yan Wang, Xiao-Dan Mao, Shui-Hua Zhang and Peng-Ming Sun
    Citation: Journal of Translational Medicine 2023 21:204
    Content type: Research Published on:

  45. Alterations in the MET gene, including amplifications and exon 14 skipping mutations, have been identified as actionable oncogenic alterations. However, MET fusions are rarely detected in lung cancer, and thei...

    Authors: Dantong Sun, Weizheng Wu, Li Wang, Jialin Qu, Qiman Han, Huiyun Wang, Shanai Song, Ning Liu, Yongjie Wang and Helei Hou
    Citation: Journal of Translational Medicine 2023 21:150
    Content type: Research Published on:

  46. Valtrate, a natural compound isolated from the root of Valeriana, exhibits antitumor activity in many cancers through different mechanisms. However, its efficacy for the treatment of glioblastoma (GBM), a tumor t...

    Authors: Xuemeng Liu, Yaotian Hu, Zhiyi Xue, Xun Zhang, Xiaofei Liu, Guowei Liu, Muzi Wen, Anjing Chen, Bin Huang, Xingang Li, Ning Yang and Jian Wang
    Citation: Journal of Translational Medicine 2023 21:147
    Content type: Research Published on:

  47. The incidence of bladder cancer (BCa) is approximately four times higher in men than in women. To develop effective BCa treatments, there is an urgent need to understand the differences in the BCa control mech...

    Authors: Jaekwon Seok, Hee Jeong Kwak, Yeonjoo Kwak, Moonjung Lee, Kyoung Sik Park, Aram Kim and Ssang-Goo Cho
    Citation: Journal of Translational Medicine 2023 21:129
    Content type: Research Published on:

  49. The overall survival rate of patients with advanced ovarian cancer (OC) has remained static for several decades. Advanced ovarian cancer is known for its poor prognosis due to extensive metastasis. Epigenetic ...

    Authors: Jieyu Wang, Fangfang Zhong, Jun Li, Huiran Yue, Wenzhi Li and Xin Lu
    Citation: Journal of Translational Medicine 2023 21:38
    Content type: Research Published on:

  50. NOC2 like nucleolar associated transcriptional repressor (NOC2L) was recently identified as a novel inhibitor of histone acetyltransferase (INHAT). NOC2L is found to have two INHAT function domains and regulat...

    Authors: Siyi Lu, Zhaoyu Chen, Zhenzhen Liu and Zhentao Liu
    Citation: Journal of Translational Medicine 2023 21:31
    Content type: Review Published on:

Journal of Translational Medicine

ISSN: 1479-5876

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