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Disease biomarkers

Section edited by Xiangdong Wang

This section aims to bridge the identification and validation of discovered gene or protein-based, network or dynamic network biomarkers with human diseases, patient phenotypes, or clinical applications, and accelerate the development of human disease-specific biomarkers for the early diagnosis, monitoring, evaluation, and prediction of diseases. Conditions including cancers, cardiovascular and metabolic diseases will be the focus of study. This section will promote the innovation and development of disease-specific biomarkers by integrating multidisciplinary aspects of science.

Studies considered for publication include those regarding the development of advanced biotechnologies for biomarker discovery and development, identifying biomarkers associated with the early detection of diseases, monitoring of disease severity and duration as well as patient responses to therapies, prediction of patient outcomes and the evaluation, regulation and ethics of disease biomarkers.

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  1. Osteoporosis is characterised by low bone mass and structural deterioration of bone tissue, resulting in increased fragility and susceptibility to fracture. Osteoporotic fractures are a significant cause of mo...

    Authors: Gillian Wheater, Mohsen Elshahaly, Stephen P Tuck, Harish K Datta and Jacob M van Laar

    Citation: Journal of Translational Medicine 2013 11:201

    Content type: Review

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  2. Increasing evidence indicates that deregulation of microRNAs (miRNAs) is involved in tumorigenesis. Downregulation of microRNA-503 has been observed in various types of diseases, including cancer. However, the...

    Authors: Fenqiang Xiao, Wu zhang, Liming Chen, Fei Chen, Haiyang Xie, Chunyang Xing, Xiaobo Yu, Songming Ding, Kangjie Chen, Haijun Guo, Jun Cheng, Shusen Zheng and Lin Zhou

    Citation: Journal of Translational Medicine 2013 11:195

    Content type: Research

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  3. After hematopoietic stem cell transplantation (HSCT) T- and B-cell reconstitution from primary lymphoid organs are a prerequisite for an effective early lymphocyte reconstitution and a long-term survival for a...

    Authors: Angela Mensen, Christoph Ochs, Andrea Stroux, Friedrich Wittenbecher, Martin Szyska, Luisa Imberti, Simon Fillatreau, Lutz Uharek, Renate Arnold, Bernd Dörken, Andreas Thiel, Carmen Scheibenbogen and Il-Kang Na

    Citation: Journal of Translational Medicine 2013 11:188

    Content type: Research

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  4. Hypoxia inducible factor-1 alpha (HIF-1α), induced by tumor hypoxia, regulates tumor cell metabolism and metastasis by up-regulation of c-Met, carbonic anhydrase 9 (CA9) and glucose transporter 1 (GLUT1). The ...

    Authors: Bo Wook Kim, Hanbyoul Cho, Joon-Yong Chung, Catherine Conway, Kris Ylaya, Jae-Hoon Kim and Stephen M Hewitt

    Citation: Journal of Translational Medicine 2013 11:185

    Content type: Research

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  5. The aim of the present study was to investigate within ovarian carcinoma and normal ovarian biopsies the gene expression of multiple secretoglobin family members relative to mammaglobin B, which we previously ...

    Authors: Eliana Bignotti, Renata A Tassi, Stefano Calza, Antonella Ravaggi, Elisa Rossi, Carla Donzelli, Paola Todeschini, Chiara Romani, Elisabetta Bandiera, Laura Zanotti, Mario Carnazza, Francesco Quadraro, Germana Tognon, Enrico Sartori, Sergio Pecorelli, Dana M Roque…

    Citation: Journal of Translational Medicine 2013 11:162

    Content type: Research

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  6. The cell division cycle 20 homolog (CDC20) is an essential cofactor of the anaphase-promoting complex (APC/C). CDC20 overexpression has been detected in many types of human cancers; however, its clinical role ...

    Authors: Wen-jing Wu, Kai-shun Hu, De-shen Wang, Zhao-lei Zeng, Dong-sheng Zhang, Dong-liang Chen, Long Bai and Rui-hua Xu

    Citation: Journal of Translational Medicine 2013 11:142

    Content type: Research

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  7. The aim of this study was to analyze the expression of protein tyrosine kinase 6 (PTK6) in nasopharyngeal carcinoma (NPC) samples, and to identify whether PTK6 can serve as a biomarker for the diagnosis and pr...

    Authors: Li-na Liu, Pei-yu Huang, Zhi-rui Lin, Li-juan Hu, Jian-zhong Liang, Man-zhi Li, Lin-quan Tang, Mu-sheng Zeng, Qian Zhong and Bo-hang Zeng

    Citation: Journal of Translational Medicine 2013 11:140

    Content type: Research

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  8. Gadd45a is a member of the Gadd45 family of genes that are known stress sensors. Gadd45a has been shown to serve as an effector in oncogenic stress in breast carcinogenesis in murine models. The present study ...

    Authors: Jennifer S Tront, Alliric Willis, Yajue Huang, Barbara Hoffman and Dan A Liebermann

    Citation: Journal of Translational Medicine 2013 11:131

    Content type: Research

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  9. T-cell receptor excision circles (TRECs) and kappa-deleting recombination excision circles (KRECs) are circular DNA segments generated in T and B cells during their maturation in the thymus and bone marrow. Th...

    Authors: Federico Serana, Marco Chiarini, Cinzia Zanotti, Alessandra Sottini, Diego Bertoli, Andrea Bosio, Luigi Caimi and Luisa Imberti

    Citation: Journal of Translational Medicine 2013 11:119

    Content type: Review

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  10. Although the prognostic roles of β-catenin expression in non-small cell lung cancer (NSCLC) have been reported in several immunohistochemical (IHC) studies, the results were not consistent because some studies...

    Authors: Xi-Qing Li, Xing-Long Yang, Gong Zhang, Si-Pei Wu, Xu-Bing Deng, Sheng-Jun Xiao, Qiu-Zhen Liu, Kai-Tai Yao and Guang-Hui Xiao

    Citation: Journal of Translational Medicine 2013 11:114

    Content type: Research

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  11. Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the adult mammalian brain, but exerts physiologic effects other than that on neurotransmitter in non-neuronal peripheral tissues and or...

    Authors: Xiaoxue Zhang, Rong Zhang, Yuanjie Zheng, Jianfei Shen, Dakai Xiao, Jin Li, Xiaoshun Shi, Liyan Huang, Hailing Tang, Jun Liu, Jianxing He and Haibo Zhang

    Citation: Journal of Translational Medicine 2013 11:102

    Content type: Research

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  12. The bone morphogenetic family proteins (BMP) are phytogenetically conserved proteins, which are essential for embryonic development. The key regulatory subunit, the bone morphogenetic protein 4 (BMP4), is over...

    Authors: Zhaoshi Bao, Chuanbao Zhang, Wei Yan, Yanwei Liu, Mingyang Li, Wei Zhang and Tao Jiang

    Citation: Journal of Translational Medicine 2013 11:100

    Content type: Research

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  13. Chronic fatigue syndrome (CFS) is a debilitating disorder characterized by persistent fatigue that is not alleviated by rest. The lack of a clearly identified underlying mechanism has hindered the development ...

    Authors: Elizabeth Ann Stringer, Katharine Susanne Baker, Ian R Carroll, Jose G Montoya, Lily Chu, Holden T Maecker and Jarred W Younger

    Citation: Journal of Translational Medicine 2013 11:93

    Content type: Research

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  14. Multiple myeloma (MM) is a low proliferative tumor of postgerminal center plasma cell (PC). Centrosome amplification (CA) is supposed to be one of the mechanisms leading to chromosomal instability. Also, CA is...

    Authors: Elena Dementyeva, Fedor Kryukov, Lenka Kubiczkova, Pavel Nemec, Sabina Sevcikova, Ivana Ihnatova, Jiri Jarkovsky, Jiri Minarik, Zdena Stefanikova, Petr Kuglik and Roman Hajek

    Citation: Journal of Translational Medicine 2013 11:77

    Content type: Research

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  15. The phosphatidylinositol 3-kinase (PI3K) pathway plays an important role in multiple myeloma (MM), a blood cancer associated with uncontrolled proliferation of bone marrow plasma cells. This study aimed to dev...

    Authors: Congfen Li, Chikara Takahashi, Liangxuan Zhang, Mahrukh Huseni, Basha Stankovich, Haider Mashhedi, Joanna Lee, Dorothy French, Jeff Eastham Anderson, Doris Kim, Kathy Howell, Matthew J Brauer, Marcin Kowanetz, Yibing Yan, Eric Humke, Allen Ebens…

    Citation: Journal of Translational Medicine 2013 11:76

    Content type: Methodology

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  16. Treatment with ipilimumab, a fully human anti-CTLA-4 antibody approved for the treatment of advanced melanoma, is associated with some immune-related adverse events (irAEs) such as colitis (gastrointestinal ir...

    Authors: Vafa Shahabi, David Berman, Scott D Chasalow, Lisu Wang, Zenta Tsuchihashi, Beihong Hu, Lisa Panting, Maria Jure-Kunkel and Rui-Ru Ji

    Citation: Journal of Translational Medicine 2013 11:75

    Content type: Research

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  17. Personalized chemotherapy based on molecular biomarkers can maximize anticancer efficiency. We aim to investigate predictive biomarkers capable of predicting response to irinotecan-based treatment in gastric c...

    Authors: Jie Shen, Jia Wei, Hao Wang, Guofeng Yue, Lixia Yu, Yang Yang, Li Xie, Zhengyun Zou, Xiaoping Qian, Yitao Ding, Wenxian Guan and Baorui Liu

    Citation: Journal of Translational Medicine 2013 11:73

    Content type: Research

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  18. Several peripheral proteins that might be useful for detecting the presence of ectopic pregnancy (EP) have been evaluated, but none have been proven entirely useful in the clinic. We investigated the presence ...

    Authors: Shien Zou, Xin Li, Yi Feng, Shan Sun, Jin Li, Emil Egecioglu, Håkan Billig and Ruijin Shao

    Citation: Journal of Translational Medicine 2013 11:44

    Content type: Research

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  19. It is well known that the disease progression in cystic fibrosis (CF) patients may be diverse in subjects with identical mutation in CFTR gene. It is quite possible that such heterogeneity is associated with TNF-

    Authors: Galina Shmarina, Alexander Pukhalsky, Nika Petrova, Ekaterina Zakharova, Lucine Avakian, Nikolai Kapranov and Vladimir Alioshkin

    Citation: Journal of Translational Medicine 2013 11:19

    Content type: Research

    Published on:

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