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Disease Biomarkers

Section edited by Xiangdong Wang and Hao Fang

The Disease Biomarkers section aims to bridge the identification and validation of discovered gene or protein-based, network or dynamic network biomarkers with human diseases, patient phenotypes, or clinical applications, and accelerate the development of human disease-specific biomarkers for the early diagnosis, monitoring, evaluation, and prediction of diseases. Conditions including cancers, cardiovascular and metabolic diseases will be the focus of study. This section will promote the innovation and development of disease-specific biomarkers by integrating multidisciplinary aspects of science.

Studies considered for publication include those regarding the development of advanced biotechnologies for biomarker discovery and development, identifying biomarkers associated with the early detection of diseases, monitoring of disease severity and duration as well as patient responses to therapies, prediction of patient outcomes and the evaluation, regulation and ethics of disease biomarkers.

Featured articles

Microfluidic devices for neutrophil chemotaxis studies

Review | Wenjie Zhao et al

Plasma proteomic analysis of autoimmune hepatitis in an improved AIH mouse model

Research | Han Wang et al

Multi-omic serum biomarkers for prognosis of disease progression in prostate cancer

Research | Michael A. Kiebish et al

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  1. Nonunion is a failure of healing following a bone fracture. Its physiopathology remains partially unclear and the discovery of new mediators could promote the understanding of bone healing.

    Authors: Dominique de Seny, Gaël Cobraiville, Pierre Leprince, Marianne Fillet, Charlotte Collin, Myrielle Mathieu, Jean-Philippe Hauzeur, Valérie Gangji and Michel G. Malaise
    Citation: Journal of Translational Medicine 2016 14:258
  2. Idiopathic pulmonary fibrosis (IPF) identifies a specific lung disorder characterized by chronic, progressive fibrosing interstitial pneumonia of unknown etiology, which lacks effective treatment. According to...

    Authors: Giulia M. Stella, Alessandra Gentile, Alice Balderacchi, Federica Meloni, Melissa Milan and Silvia Benvenuti
    Citation: Journal of Translational Medicine 2016 14:256

    The Erratum to this article has been published in Journal of Translational Medicine 2017 15:194

  3. Epigenetic silencing mediated by CpG island methylation is a common feature of many cancers. Characterizing aberrant DNA methylation changes associated with prostate carcinogenesis could potentially identify a...

    Authors: Giorgia Gurioli, Samanta Salvi, Filippo Martignano, Flavia Foca, Roberta Gunelli, Matteo Costantini, Giacomo Cicchetti, Ugo De Giorgi, Persio Dello Sbarba, Daniele Calistri and Valentina Casadio
    Citation: Journal of Translational Medicine 2016 14:249
  4. Severe early childhood caries (s-ECC), which has quite high prevalence among children, is a widespread problem with significant impacts among both developing and developed countries. At present, it is widely k...

    Authors: Xiangyu Sun, Xin Huang, Xu Tan, Yan Si, Xiaozhe Wang, Feng Chen and Shuguo Zheng
    Citation: Journal of Translational Medicine 2016 14:240
  5. NK cell cytotoxicity is regulated by the types of the interaction between killer immunoglobulin-like receptors (KIRs) and human leukocyte antigen (HLA) class I ligands on target cells and the different binding...

    Authors: Angelica Canossi, Anna Aureli, Tiziana Del Beato, Piero Rossi, Luana Franceschilli, Flavio De Sanctis, Pierpaolo Sileri, Nicola di Lorenzo, Oreste Buonomo, Davide Lauro, Adriano Venditti and Giuseppe Sconocchia
    Citation: Journal of Translational Medicine 2016 14:239
  6. Hemodialysis patients have higher rates of cardiovascular morbidity and mortality compared to the general population. Mannose-binding lectin (MBL) plays an important role in the development of cardiovascular d...

    Authors: Felix Poppelaars, Mariana Gaya da Costa, Stefan P. Berger, Solmaz Assa, Anita H. Meter-Arkema, Mohamed R. Daha, Willem J. van Son, Casper F. M. Franssen and Marc A. J. Seelen
    Citation: Journal of Translational Medicine 2016 14:236

    The Erratum to this article has been published in Journal of Translational Medicine 2016 14:245

  7. The dependency of miRNA abundance from physiological processes such as exercises remains partially understood. We set out to analyze the effect of physical exercises on miRNA profiles in blood and plasma of en...

    Authors: Anne Hecksteden, Petra Leidinger, Christina Backes, Stefanie Rheinheimer, Mark Pfeiffer, Alexander Ferrauti, Michael Kellmann, Farbod Sedaghat, Benjamin Meder, Eckart Meese, Tim Meyer and Andreas Keller
    Citation: Journal of Translational Medicine 2016 14:219

    The Erratum to this article has been published in Journal of Translational Medicine 2016 14:293

  8. Colorectal cancer is a preventable disease if caught at early stages. This disease is highly aggressive and has a higher incidence in African Americans. Several biomarkers and mutations of aggressive tumor beh...

    Authors: Hassan Ashktorab, Pia Hermann, Mehdi Nouraie, Babak Shokrani, Edward Lee, Tahmineh Haidary, Hassan Brim and Ulrike Stein
    Citation: Journal of Translational Medicine 2016 14:215
  9. Individual patients show a large variability in albuminuria response to angiotensin receptor blockers (ARB). Identifying novel biomarkers that predict ARB response may help tailor therapy. We aimed to discover...

    Authors: Michelle J. Pena, Andreas Heinzel, Peter Rossing, Hans-Henrik Parving, Guido Dallmann, Kasper Rossing, Steen Andersen, Bernd Mayer and Hiddo J. L. Heerspink
    Citation: Journal of Translational Medicine 2016 14:203
  10. Hepatocellular carcinoma (HCC), a primary liver malignancy, is the most common cancer in males and fourth common cancer in females in Taiwan. HCC patients usually have a poor prognosis due to late diagnosis. I...

    Authors: Yu-Chiau Shyu, Tung-Liang Lee, Mu-Jie Lu, Jim-Ray Chen, Rong-Nan Chien, Huang-Yang Chen, Ji-Fan Lin, Ann-Ping Tsou, Yu-Hsien Chen, Chia-Wen Hsieh and Ting-Shuo Huang
    Citation: Journal of Translational Medicine 2016 14:200
  11. Occurrence and progression of hepatocellular carcinoma (HCC) are associated with hepatitis B virus (HBV) infection. miR-1269b is up-regulated in HCC cells and tissues. However, the regulation of miR-1269b expr...

    Authors: Xiao-xiao Kong, Yan-ru Lv, Li-ping Shao, Xiang-yang Nong, Guang-ling Zhang, Yi Zhang, Hong-xia Fan, Min Liu, Xin Li and Hua Tang
    Citation: Journal of Translational Medicine 2016 14:189
  12. To date, there are no effective therapeutic targeting agents for triple-negative breast cancer (TNBC), and PD-L1 has presented potential as an effective marker of immunotherapeutic agents. The aim of this stud...

    Authors: Woo Young Sun, Yu Kyung Lee and Ja Seung Koo
    Citation: Journal of Translational Medicine 2016 14:173
  13. MicroRNAs have the potential as diagnostic biomarkers and therapeutic targets in autoimmune diseases. However, very limited studies have evaluated the expression of microRNA profile in thyroid gland related to...

    Authors: Jin Zhu, Yuehua Zhang, Weichen Zhang, Wei Zhang, Linni Fan, Lu Wang, Yixiong Liu, Shasha Liu, Ying Guo, Yingmei Wang, Jun Yi, Qingguo Yan, Zhe Wang and Gaosheng Huang
    Citation: Journal of Translational Medicine 2016 14:166
  14. Adjuvant chemotherapy in patients with resected esophageal squamous cell cancer (ESCC) remains controversial for its uncertain role in improving overall survival (OS). Nucleotide excision repair (NER) removes ...

    Authors: Fei Zhou, Meiling Zhu, Mengyun Wang, Lixin Qiu, Lei Cheng, Ming Jia, Jiaqing Xiang and Qingyi Wei
    Citation: Journal of Translational Medicine 2016 14:154
  15. Diabetes testing using saliva, rather than blood and urine, could facilitate diabetes screening in public spaces. We previously identified 1,5-anhydro-d-glucitol (1,5-AG) in saliva as a diabetes biomarker. The Gl...

    Authors: Anna Halama, Michal Kulinski, Sara Abdul Kader, Noothan J. Satheesh, Abdul Badi Abou-Samra, Karsten Suhre and Ramzi M. Mohammad
    Citation: Journal of Translational Medicine 2016 14:140
  16. The prognosis of children with metastatic stage 4 neuroblastoma (NB) has remained poor in the past decade.

    Authors: Daniela Formicola, Giuseppe Petrosino, Vito Alessandro Lasorsa, Piero Pignataro, Flora Cimmino, Simona Vetrella, Luca Longo, Gian Paolo Tonini, André Oberthuer, Achille Iolascon, Matthias Fischer and Mario Capasso
    Citation: Journal of Translational Medicine 2016 14:142
  17. Esophageal squamous cell carcinoma (ESCC) is one of the most aggressively malignant tumors with dismal prognosis. Profilin 2 (PFN2) is an actin-binding protein that regulates the dynamics of actin polymerizati...

    Authors: Xiao-bin Cui, Shu-mao Zhang, Yue-xun Xu, Hong-wei Dang, Chun-xia Liu, Liang-hai Wang, Lan Yang, Jian-ming Hu, Wei-hua Liang, Jin-fang Jiang, Na Li, Yong Li, Yun-zhao Chen and Feng Li
    Citation: Journal of Translational Medicine 2016 14:137
  18. There is an unmet need for more efficient patient stratification for receiving trastuzumab in the metastatic breast cancer (mBC) setting, since only part of such patients benefit from the addition of this agen...

    Authors: Helen Gogas, Vassiliki Kotoula, Zoi Alexopoulou, Christos Christodoulou, Ioannis Kostopoulos, Mattheos Bobos, Georgia Raptou, Elpida Charalambous, Eleftheria Tsolaki, Ioannis Xanthakis, George Pentheroudakis, Angelos Koutras, Dimitrios Bafaloukos, Pavlos Papakostas, Gerasimos Aravantinos, Amanda Psyrri…
    Citation: Journal of Translational Medicine 2016 14:136
  19. The receptor for activated C kinase 1 (RACK1) is involved in various cancers, but its roles in nasopharyngeal carcinoma (NPC) have not yet been fully elucidated.

    Authors: Hong Peng, Ping-Gui Gong, Jin-Bang Li, Long-Mei Cai, Le Yang, Yun-yi Liu, Kai-tai Yao and Xin Li
    Citation: Journal of Translational Medicine 2016 14:131
  20. Podocalyxin-like 1 (PODXL) is an anti-adhesive transmembrane protein that has been demonstrated to be an independent factor of poor prognosis in colorectal cancer (CRC). The gene encoding PODXL is located to c...

    Authors: Anna H. Larsson, Sophie Lehn, Sakarias Wangefjord, Emelie Karnevi, Eugenia Kuteeva, Magnus Sundström, Björn Nodin, Mathias Uhlén, Jakob Eberhard, Helgi Birgisson and Karin Jirström
    Citation: Journal of Translational Medicine 2016 14:128
  21. The oncogenic role of the fibroblast growth factor receptor (FGFR) has been recognized in a number of different cancer types. However, the prognostic significance of FGFRs has not been elucidated yet in cervic...

    Authors: Chel Hun Choi, Joon-Yong Chung, Jae-Hoon Kim, Byoung-Gie Kim and Stephen M. Hewitt
    Citation: Journal of Translational Medicine 2016 14:124
  22. Circulating microRNAs (miRNAs) emerge as novel biomarkers in cardiovascular diseases. Diagnosing acute pulmonary embolism (PE) remains challenging due to a diverse clinical presentation and the lack of specifi...

    Authors: Thorsten Kessler, Jeanette Erdmann, Baiba Vilne, Petra Bruse, Volkhard Kurowski, Patrick Diemert, Heribert Schunkert and Hendrik B. Sager
    Citation: Journal of Translational Medicine 2016 14:120
  23. Annexins are Ca2+-regulated phospholipid-binding proteins that play an important role in the cell life cycle, exocytosis, and apoptosis. Annexin A11 is one of the oldest vertebrate annexins that has a crucial rol...

    Authors: Mehdi Mirsaeidi, Sanaz Gidfar, Ann Vu and Dean Schraufnagel
    Citation: Journal of Translational Medicine 2016 14:89
  24. S100A13 and high mobility group A (HMGA1) are known to play essential roles in the carcinogenesis and progression of cancer. However, the correlation between S100A13 and HMGA1 during cancer progression is not...

    Authors: Jing Zhong, Chang Liu, Ya-jun Chen, Qing-hai Zhang, Jing Yang, Xuan Kang, Si-Rui Chen, Ge-bo Wen, Xu-yu Zu and Ren-xian Cao
    Citation: Journal of Translational Medicine 2016 14:80
  25. Low back pain and sciatica caused by intervertebral disc (IVD) disease are associated with inflammatory responses. The cytokine interleukin 17 (IL-17) is elevated in herniated and degenerated IVD tissues and a...

    Authors: Jing-kun Li, Lin Nie, Yun-peng Zhao, Yuan-qiang Zhang, Xiaoqing Wang, Shuai-shuai Wang, Yi Liu, Hua Zhao and Lei Cheng
    Citation: Journal of Translational Medicine 2016 14:77
  26. Beta-2-microglobulin (B2M), a light chain subunit of the major histocompatibility complex (MHC) class I complex, has been implicated in tumorigenesis. However, whether it is expressed in different epithelial-t...

    Authors: Wenwen Sun, Lu Gui, Xulei Zuo, Lingyun Zhang, Daibing Zhou, Xiaoling Duan, Weimin Ren and Guoxiong Xu
    Citation: Journal of Translational Medicine 2016 14:75
  27. Despite the efficacy of decitabine treatment in myelodysplastic syndrome (MDS), no definite predictor of response is known. In this study, we investigated whether the expression levels of human equilibrative n...

    Authors: Lingyun Wu, Wenhui Shi, Xiao Li, Chunkang Chang, Feng Xu, Qi He, Dong Wu, Jiying Su, Liyu Zhou, Luxi Song, Chao Xiao and Zheng Zhang
    Citation: Journal of Translational Medicine 2016 14:66
  28. C14orf166 (chromosome 14 open reading frame 166) plays a crucial role in some tumors, but its role in bladder cancer hasn’t been explored.

    Authors: Mingkun Chen, Yunlin Ye, Baojia Zou, Suping Guo, Fangjian Zhou, Keshi Lu, Jianye Liu, Zhenzhou Xu, Hui Han, Zhuowei Liu, Yonghong Li, Kai Yao, Cundong Liu and Zike Qin
    Citation: Journal of Translational Medicine 2016 14:55
  29. Urine based assays that can non-invasively detect bladder cancer (BCa) have the potential to reduce unnecessary and invasive procedures. The purpose of this study was to develop a multiplex immunoassay that ca...

    Authors: Yoshiko Shimizu, Hideki Furuya, Peter Bryant Greenwood, Owen Chan, Yunfeng Dai, Mark D. Thornquist, Steve Goodison and Charles J. Rosser
    Citation: Journal of Translational Medicine 2016 14:31
  30. Mitochondrial dysfunction has been hypothesized to occur in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), a disease characterized by fatigue, cognitive difficulties, pain, malaise, and exercise ...

    Authors: Paul Billing-Ross, Arnaud Germain, Kaixiong Ye, Alon Keinan, Zhenglong Gu and Maureen R. Hanson
    Citation: Journal of Translational Medicine 2016 14:19
  31. The challenging diagnosis and poor prognosis of cholangiocarcinoma require the determination of biomarkers. Autoantibodies could be used in the clinic as diagnostic markers for the early detection of tumours. ...

    Authors: Mohammad Zahid Mustafa, Viet Hung Nguyen, François Le Naour, Eleonora De Martin, Elvire Beleoken, Catherine Guettier, Catherine Johanet, Didier Samuel, Jean-Charles Duclos-Vallee and Eric Ballot
    Citation: Journal of Translational Medicine 2016 14:17
  32. Cabozantinib is an orally available inhibitor of tyrosine kinases including VEGFR2 and c-MET. We performed a post hoc analysis to find associations between select plasma biomarkers and treatment response in p...

    Authors: Raya Leibowitz-Amit, Melania Pintilie, Leila Khoja, Arun A. Azad, Raanan Berger, A. Douglas Laird, Dana T. Aftab, Kim N. Chi and Anthony M. Joshua
    Citation: Journal of Translational Medicine 2016 14:12
  33. Recent studies have linked non-alcoholic fatty liver disease (NAFLD) to a reduced bone mineral density (BMD). We aimed to detect the quantitative association of liver fat content (LFC) and serum alanine aminot...

    Authors: Ming-Feng Xia, Huan-Dong Lin, Hong-Mei Yan, Hua Bian, Xin-Xia Chang, Lin-Shan Zhang, Wan-Yuan He and Xin Gao
    Citation: Journal of Translational Medicine 2016 14:11
  34. Colorectal cancer (CRC) remains a major public concern. While conventional chemotherapeutic regimens have proved useful against advanced/metastatic diseases, progresses are to be made to effectively cure the l...

    Authors: Christophe Bounaix Morand du Puch, Michelle Nouaille, Stéphanie Giraud, Anaïs Labrunie, Sandrine Luce, Pierre-Marie Preux, François Labrousse, Alain Gainant, Nicole Tubiana-Mathieu, Valérie Le Brun-Ly, Denis Valleix, Angélique Guillaudeau, Laura Mesturoux, Béma Coulibaly, Christophe Lautrette and Muriel Mathonnet
    Citation: Journal of Translational Medicine 2016 14:10
  35. Hepatocarcinogenesis is a multistep process characterized in patients with chronic liver diseases by a spectrum of hepatic nodules that mark the progression from regenerative nodules to dysplastic lesions foll...

    Authors: Chengyuan Peng, Slávka Kaščáková, Franck Chiappini, Natalia Olaya, Christophe Sandt, Ibraheem Yousef, Didier Samuel, Paul Dumas, Catherine Guettier and François Le Naour
    Citation: Journal of Translational Medicine 2016 14:9
  36. Histone deacetylase (HDAC) inhibitors are widely used in clinical investigation as novel drug targets. For example, panobinostat and vorinostat have been used to treat patients with melanoma. However, HDAC inh...

    Authors: Jiaqi Liu, Jianying Gu, Zihao Feng, Yanhong Yang, Ningwen Zhu, Weiyue Lu and Fazhi Qi
    Citation: Journal of Translational Medicine 2016 14:7
  37. Orthotopic liver transplantation (OLT) can be an effective treatment option for certain patients with early stage hepatocellular carcinoma (HCC) meeting Milan, UCSF, or Hangzhou criteria. However, HCC recurren...

    Authors: Feng Xue, Brandon W. Higgs, Jiaqi Huang, Chris Morehouse, Wei Zhu, Xin Yao, Philip Brohawn, Zhan Xiao, Yinong Sebastian, Zheng Liu, Yun Xia, Dong Shen, Mike Kuziora, Zhengwei Dong, Hulin Han, Yi Gu…
    Citation: Journal of Translational Medicine 2015 13:379
  38. Diabetic nephropathy (DN) is the leading cause of chronic kidney failure and end-stage kidney disease. More accurate and non-invasive test for the diagnosis and monitoring the progression of DN is urgently nee...

    Authors: Zhengguang Guo, Xuejiao Liu, Menglin Li, Chen Shao, Jianling Tao, Wei Sun and Mingxi Li
    Citation: Journal of Translational Medicine 2015 13:371
  39. Plasmodium falciparum malaria in India is characterized by high rates of severe disease, with multiple organ dysfunction (MOD)—mainly associated with acute renal failure (ARF)—and incr...

    Authors: Fabien Herbert, Nicolas Tchitchek, Devendra Bansal, Julien Jacques, Sulabha Pathak, Christophe Bécavin, Constantin Fesel, Esther Dalko, Pierre-André Cazenave, Cristian Preda, Balachandran Ravindran, Shobhona Sharma, Bidyut Das and Sylviane Pied
    Citation: Journal of Translational Medicine 2015 13:369
  40. Prompt antibiotic treatment of early stage Lyme borreliosis (LB) prevents progression to severe multisystem disease. There is a clinical need to improve the diagnostic specificity of early stage Lyme assays in...

    Authors: Ruben Magni, Benjamin H. Espina, Ketul Shah, Benjamin Lepene, Christine Mayuga, Temple A. Douglas, Virginia Espina, Sally Rucker, Ross Dunlap, Emanuel F. III Petricoin, Mary Frekko Kilavos, Donald M. Poretz, Gilbert R. Irwin, Samuel M. Shor, Lance A. Liotta and Alessandra Luchini
    Citation: Journal of Translational Medicine 2015 13:346
  41. Studies report conflicting evidence regarding the existence of a DCIS-associated premalignant pathway in BRCA mutation carriers. We aimed to examine the prevalence, phenotype, and expression of oncodrivers in ...

    Authors: Rachel L. Yang, Rosemarie Mick, Kathreen Lee, Holly L. Graves, Katherine L. Nathanson, Susan M. Domchek, Rachel R. Kelz, Paul J. Zhang and Brian J. Czerniecki
    Citation: Journal of Translational Medicine 2015 13:335
  42. Several promising biomarkers have been found for RCC, but none of them has been used in clinical practice for predicting tumour progression. The most widely used features for predicting tumour aggressiveness s...

    Authors: Clizia Chinello, Marta Cazzaniga, Gabriele De Sio, Andrew James Smith, Angelica Grasso, Bernardo Rocco, Stefano Signorini, Marco Grasso, Silvano Bosari, Italo Zoppis, Giancarlo Mauri and Fulvio Magni
    Citation: Journal of Translational Medicine 2015 13:332
  43. The wingless-type MMTV integration site (Wnt) signaling is a group of signal transduction pathways. In canonical Wnt pathway, Wnt ligands bind to low-density lipoprotein receptor-related protein 5 or 6 (LRP5 o...

    Authors: Jingsheng Tuo, Yujuan Wang, Rui Cheng, Yichao Li, Mei Chen, Fangfang Qiu, Haohua Qian, Defen Shen, Rosana Penalva, Heping Xu, Jian-Xing Ma and Chi-Chao Chan
    Citation: Journal of Translational Medicine 2015 13:330
  44. Esophageal squamous cell carcinoma (ESCC) is a highly lethal cancer, and its underlying molecular mechanisms are poorly understood. Recent large-scale genome-wide association studies in Chinese Han populations...

    Authors: Xiao-Bin Cui, Yao-yuan Shen, Ting-ting Jin, Su Li, Ting-ting Li, Shu-mao Zhang, Hao Peng, Chun-xia Liu, Shu-gang Li, Lan Yang, Na Li, Jian-ming Hu, Jin-Fang Jiang, Man Li, Wei-hua Liang, Yong Li…
    Citation: Journal of Translational Medicine 2015 13:321
  45. The gastric cancer is one of the most common and mortal cancer worldwide. The initial asymptomatic development and further nonspecific symptoms result in diagnosis at the advanced stage with poor prognosis. Ye...

    Authors: Agata Abramowicz, Anna Wojakowska, Agnieszka Gdowicz-Klosok, Joanna Polanska, Pawel Rodziewicz, Pawel Polanowski, Agnieszka Namysl-Kaletka, Monika Pietrowska, Jerzy Wydmanski and Piotr Widlak
    Citation: Journal of Translational Medicine 2015 13:304
  46. Interferons (IFNs) have potent anti-proliferative, pro-apoptotic, and immunomodulatory activities against cancer. However, the clinical utility of IFNs is limited by toxicity and pharmacokinetics making it dif...

    Authors: Junjie Chen, Jialu Zhao, Lefu Chen, Nian Dong, Zhaojian Ying, Zhenzhen Cai, Dongxiang Ji, Yong Zhang, Li Dong, Yuping Li, Lei Jiang, Michael J. Holtzman and Chengshui Chen
    Citation: Journal of Translational Medicine 2015 13:293
  47. Post-transcriptional regulation by heterogeneous ribonucleoproteins (hnRNPs) is an important regulatory paradigm in cancer development. Our proteomic analysis revealed hnRNPD overexpression in oral dysplasia ...

    Authors: Manish Kumar, Ajay Matta, Olena Masui, Gunjan Srivastava, Jatinder Kaur, Alok Thakar, Nootan Kumar Shukla, Ajoy RoyChoudhury, Meherchand Sharma, Paul G. Walfish, K. W. Michael Siu, Shyam Singh Chauhan and Ranju Ralhan
    Citation: Journal of Translational Medicine 2015 13:285
  48. Activation of the MET oncogene promotes tumor growth, invasion and metastasis in several tumor types. Additionally, MET is activated as a compensatory pathway in the presence of EGFR blockade, thus resulting in a...

    Authors: Juan Madoz-Gúrpide, Sandra Zazo, Cristina Chamizo, Victoria Casado, Cristina Caramés, Eduardo Gavín, Ion Cristóbal, Jesús García-Foncillas and Federico Rojo
    Citation: Journal of Translational Medicine 2015 13:282
  49. Definitive radiation therapy is the mainstay of treatment for early stage laryngeal squamous cell carcinoma (LSCC). However, up to 30% of the patients do not respond to radiotherapy. Unfortunately, we are unab...

    Authors: Danielle Maia, Ana Carolina de Carvalho, Maria Aderuza Horst, André Lopes Carvalho, Cristovam Scapulatempo-Neto and Andre Luiz Vettore
    Citation: Journal of Translational Medicine 2015 13:262

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