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Disease Biomarkers

Section edited by Xiangdong Wang and Hao Fang

The Disease Biomarkers section aims to bridge the identification and validation of discovered gene or protein-based, network or dynamic network biomarkers with human diseases, patient phenotypes, or clinical applications, and accelerate the development of human disease-specific biomarkers for the early diagnosis, monitoring, evaluation, and prediction of diseases. Conditions including cancers, cardiovascular and metabolic diseases will be the focus of study. This section will promote the innovation and development of disease-specific biomarkers by integrating multidisciplinary aspects of science.

Studies considered for publication include those regarding the development of advanced biotechnologies for biomarker discovery and development, identifying biomarkers associated with the early detection of diseases, monitoring of disease severity and duration as well as patient responses to therapies, prediction of patient outcomes and the evaluation, regulation and ethics of disease biomarkers.

Featured articles

Microfluidic devices for neutrophil chemotaxis studies

Review | Wenjie Zhao et al

Plasma proteomic analysis of autoimmune hepatitis in an improved AIH mouse model

Research | Han Wang et al

Multi-omic serum biomarkers for prognosis of disease progression in prostate cancer

Research | Michael A. Kiebish et al

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  1. The shift towards an earlier diagnosis of breast cancer (BC) highlights the need for biomarkers that would identify patients at risk for relapse and metastatic spread and indicate the potential value of additi...

    Authors: Amanda Psyrri, Konstantine T. Kalogeras, Ralph M. Wirtz, George Kouvatseas, Georgia Karayannopoulou, Anna Goussia, Flora Zagouri, Elke Veltrup, Eleni Timotheadou, Helen Gogas, Angelos Koutras, Georgios Lazaridis, Christos Christodoulou, George Pentheroudakis, Panagiota Economopoulou, Apostolos Laskarakis…
    Citation: Journal of Translational Medicine 2017 15:30
  2. Metabolic alterations play a role in the development of inflammatory myopathies (IMs). Herein, we have investigated through a multiplex assay whether proteins of energy metabolism could provide biomarkers of IMs.

    Authors: Fulvio Santacatterina, María Sánchez-Aragó, Marc Catalán-García, Glòria Garrabou, Cristina Nuñez de Arenas, Josep M. Grau, Francesc Cardellach and José M. Cuezva
    Citation: Journal of Translational Medicine 2017 15:29
  3. Due to the heterogeneity of cancer, identifying differentially methylated (DM) CpG sites between a set of cancer samples and a set of normal samples cannot tell us which patients have methylation aberrations i...

    Authors: Haidan Yan, Qingzhou Guan, Jun He, Yunqing Lin, Juan Zhang, Hongdong Li, Huaping Liu, Yunyan Gu, Zheng Guo and Fei He
    Citation: Journal of Translational Medicine 2017 15:26
  4. Maternal smoking during pregnancy results in an increased risk of low birth weight through perturbations in the utero-placental exchange. Epigenetics and mitochondrial function in fetal tissues might be molecular...

    Authors: Bram G. Janssen, Wilfried Gyselaers, Hyang-Min Byun, Harry A. Roels, Ann Cuypers, Andrea A. Baccarelli and Tim S. Nawrot
    Citation: Journal of Translational Medicine 2017 15:5
  5. Study of age related macular degeneration (AMD) has been hampered by lack of human models that represent the complexity of the disease. Here we have developed a human in vitro disease model of AMD to investiga...

    Authors: Nady Golestaneh, Yi Chu, Shuk Kei Cheng, Hong Cao, Eugenia Poliakov and Daniel M. Berinstein
    Citation: Journal of Translational Medicine 2016 14:344
  6. Earlier this year, we described an analysis of mitochondrial DNA (mtDNA) variants in myalgic encephalomyelitis (ME)/chronic fatigue syndrome (CFS) patients and healthy controls. We reported that there was no s...

    Authors: Maureen R. Hanson, Zhenglong Gu, Alon Keinan, Kaixiong Ye, Arnaud Germain and Paul Billing-Ross
    Citation: Journal of Translational Medicine 2016 14:342
  7. Conventional approaches to understand mechanisms underlying the development of pathological manifestations in ulcerative colitis (UC) mostly rely on identification of certain cell types and cytokines followed ...

    Authors: M. Föhlinger, P. Palamides, U. Mansmann, F. Beigel, M. Siebeck and R. Gropp
    Citation: Journal of Translational Medicine 2016 14:310
  8. Clinical ovulation induction induces blood estrogen (E2) in excess of physiological levels, which can hinder uterine receptivity. In contrast, progesterone produces the opposite clinical effect, suggesting that i...

    Authors: Guowu Chen, Aijie Xin, Yulin Liu, Changgen Shi, Junling Chen, Xiaofeng Tang, Ying Chen, Min Yu, Xiandong Peng, Lu Li and Xiaoxi Sun
    Citation: Journal of Translational Medicine 2016 14:303
  9. The goal of biomarker research is to identify clinically valid markers. Despite decades of research there has been disappointingly few molecules or techniques that are in use today. The “1st International NTNU...

    Authors: Ana I. Robles, Karina Standahl Olsen, Dana W.T. Tsui, Vassilis Georgoulias, Jenette Creaney, Katalin Dobra, Mogens Vyberg, Nagahiro Minato, Robert A. Anders, Anne-Lise Børresen-Dale, Jianwei Zhou, Pål Sætrom, Boye Schnack Nielsen, Michaela B. Kirschner, Hans E. Krokan, Vassiliki Papadimitrakopoulou…
    Citation: Journal of Translational Medicine 2016 14:295
  10. Bladder cancer (BCa) is among the most commonly diagnosed malignancies worldwide, and due the high rate of post-operative disease recurrence, it is one of the most prevalent in many countries. The development ...

    Authors: Steve Goodison, Osamu Ogawa, Yoshiyuki Matsui, Takashi Kobayashi, Makito Miyake, Sayuri Ohnishi, Kiyohide Fujimoto, Yunfeng Dai, Yoshiko Shimizu, Kazue Tsukikawa, Hideki Furuya and Charles J. Rosser
    Citation: Journal of Translational Medicine 2016 14:287
  11. Small cell lung cancers (SCLC) are tumors of neuroendocrine origin. Previous in vitro studies from our laboratory showed that SCLC expresses high levels of the transmembrane dense core vesicle protein IA-2 (is...

    Authors: Huanyu Xu, Tao Cai, Gilberto N. Carmona, Liron Abuhatzira and Abner L. Notkins
    Citation: Journal of Translational Medicine 2016 14:278
  12. FEAT is an intracellular protein that potently drives tumorigenesis in vivo. It is only weakly expressed in normal human tissues, including the testis. In contrast, FEAT is aberrantly upregulated in most human...

    Authors: Yan Li, Kyosuke Kobayashi, Marwa M. Mona, Chikako Satomi, Shinji Okano, Hiroyuki Inoue, Kenzaburo Tani and Atsushi Takahashi
    Citation: Journal of Translational Medicine 2016 14:275
  13. Mutations in the isocitrate dehydrogenase enzyme are present in a majority of lower-grade gliomas and secondary glioblastomas. This mis-sense mutation results in the neomorphic reduction of isocitrate dehydrog...

    Authors: Gaurav Verma, Suyash Mohan, MacLean P. Nasrallah, Steven Brem, John Y. K. Lee, Sanjeev Chawla, Sumei Wang, Rajakumar Nagarajan, M. Albert Thomas and Harish Poptani
    Citation: Journal of Translational Medicine 2016 14:274
  14. We recently demonstrated a positive effect of berberine on nonalcoholic fatty liver disease patients after 16 weeks of treatment by comparing mere lifestyle intervention in type 2 diabetes patients with berber...

    Authors: Xinxia Chang, Zhe Wang, Jinlan Zhang, Hongmei Yan, Hua Bian, Mingfeng Xia, Huandong Lin, Jiandong Jiang and Xin Gao
    Citation: Journal of Translational Medicine 2016 14:266
  15. Although important advances in the management of breast cancer (BC) have been recently accomplished, it still constitutes the leading cause of cancer death in women worldwide. BC is a heterogeneous and complex...

    Authors: Maria Amorim, Sofia Salta, Rui Henrique and Carmen Jerónimo
    Citation: Journal of Translational Medicine 2016 14:265
  16. Systemic sclerosis (SSc) is an autoimmune disease characterized by progressive fibrosis of the skin and the internal organs. In a previous work we suggested a correlation between levels of salivary psoriasin (...

    Authors: Laura Giusti, Francesca Sernissi, Elena Donadio, Federica Ciregia, Camillo Giacomelli, Gino Giannaccini, Maria Rosa Mazzoni, Antonio Lucacchini and Laura Bazzichi
    Citation: Journal of Translational Medicine 2016 14:262
  17. Nonunion is a failure of healing following a bone fracture. Its physiopathology remains partially unclear and the discovery of new mediators could promote the understanding of bone healing.

    Authors: Dominique de Seny, Gaël Cobraiville, Pierre Leprince, Marianne Fillet, Charlotte Collin, Myrielle Mathieu, Jean-Philippe Hauzeur, Valérie Gangji and Michel G. Malaise
    Citation: Journal of Translational Medicine 2016 14:258
  18. Idiopathic pulmonary fibrosis (IPF) identifies a specific lung disorder characterized by chronic, progressive fibrosing interstitial pneumonia of unknown etiology, which lacks effective treatment. According to...

    Authors: Giulia M. Stella, Alessandra Gentile, Alice Balderacchi, Federica Meloni, Melissa Milan and Silvia Benvenuti
    Citation: Journal of Translational Medicine 2016 14:256

    The Erratum to this article has been published in Journal of Translational Medicine 2017 15:194

  19. Epigenetic silencing mediated by CpG island methylation is a common feature of many cancers. Characterizing aberrant DNA methylation changes associated with prostate carcinogenesis could potentially identify a...

    Authors: Giorgia Gurioli, Samanta Salvi, Filippo Martignano, Flavia Foca, Roberta Gunelli, Matteo Costantini, Giacomo Cicchetti, Ugo De Giorgi, Persio Dello Sbarba, Daniele Calistri and Valentina Casadio
    Citation: Journal of Translational Medicine 2016 14:249
  20. Severe early childhood caries (s-ECC), which has quite high prevalence among children, is a widespread problem with significant impacts among both developing and developed countries. At present, it is widely k...

    Authors: Xiangyu Sun, Xin Huang, Xu Tan, Yan Si, Xiaozhe Wang, Feng Chen and Shuguo Zheng
    Citation: Journal of Translational Medicine 2016 14:240
  21. NK cell cytotoxicity is regulated by the types of the interaction between killer immunoglobulin-like receptors (KIRs) and human leukocyte antigen (HLA) class I ligands on target cells and the different binding...

    Authors: Angelica Canossi, Anna Aureli, Tiziana Del Beato, Piero Rossi, Luana Franceschilli, Flavio De Sanctis, Pierpaolo Sileri, Nicola di Lorenzo, Oreste Buonomo, Davide Lauro, Adriano Venditti and Giuseppe Sconocchia
    Citation: Journal of Translational Medicine 2016 14:239
  22. Hemodialysis patients have higher rates of cardiovascular morbidity and mortality compared to the general population. Mannose-binding lectin (MBL) plays an important role in the development of cardiovascular d...

    Authors: Felix Poppelaars, Mariana Gaya da Costa, Stefan P. Berger, Solmaz Assa, Anita H. Meter-Arkema, Mohamed R. Daha, Willem J. van Son, Casper F. M. Franssen and Marc A. J. Seelen
    Citation: Journal of Translational Medicine 2016 14:236

    The Erratum to this article has been published in Journal of Translational Medicine 2016 14:245

  23. The dependency of miRNA abundance from physiological processes such as exercises remains partially understood. We set out to analyze the effect of physical exercises on miRNA profiles in blood and plasma of en...

    Authors: Anne Hecksteden, Petra Leidinger, Christina Backes, Stefanie Rheinheimer, Mark Pfeiffer, Alexander Ferrauti, Michael Kellmann, Farbod Sedaghat, Benjamin Meder, Eckart Meese, Tim Meyer and Andreas Keller
    Citation: Journal of Translational Medicine 2016 14:219

    The Erratum to this article has been published in Journal of Translational Medicine 2016 14:293

  24. Colorectal cancer is a preventable disease if caught at early stages. This disease is highly aggressive and has a higher incidence in African Americans. Several biomarkers and mutations of aggressive tumor beh...

    Authors: Hassan Ashktorab, Pia Hermann, Mehdi Nouraie, Babak Shokrani, Edward Lee, Tahmineh Haidary, Hassan Brim and Ulrike Stein
    Citation: Journal of Translational Medicine 2016 14:215
  25. Individual patients show a large variability in albuminuria response to angiotensin receptor blockers (ARB). Identifying novel biomarkers that predict ARB response may help tailor therapy. We aimed to discover...

    Authors: Michelle J. Pena, Andreas Heinzel, Peter Rossing, Hans-Henrik Parving, Guido Dallmann, Kasper Rossing, Steen Andersen, Bernd Mayer and Hiddo J. L. Heerspink
    Citation: Journal of Translational Medicine 2016 14:203
  26. Hepatocellular carcinoma (HCC), a primary liver malignancy, is the most common cancer in males and fourth common cancer in females in Taiwan. HCC patients usually have a poor prognosis due to late diagnosis. I...

    Authors: Yu-Chiau Shyu, Tung-Liang Lee, Mu-Jie Lu, Jim-Ray Chen, Rong-Nan Chien, Huang-Yang Chen, Ji-Fan Lin, Ann-Ping Tsou, Yu-Hsien Chen, Chia-Wen Hsieh and Ting-Shuo Huang
    Citation: Journal of Translational Medicine 2016 14:200
  27. Occurrence and progression of hepatocellular carcinoma (HCC) are associated with hepatitis B virus (HBV) infection. miR-1269b is up-regulated in HCC cells and tissues. However, the regulation of miR-1269b expr...

    Authors: Xiao-xiao Kong, Yan-ru Lv, Li-ping Shao, Xiang-yang Nong, Guang-ling Zhang, Yi Zhang, Hong-xia Fan, Min Liu, Xin Li and Hua Tang
    Citation: Journal of Translational Medicine 2016 14:189
  28. To date, there are no effective therapeutic targeting agents for triple-negative breast cancer (TNBC), and PD-L1 has presented potential as an effective marker of immunotherapeutic agents. The aim of this stud...

    Authors: Woo Young Sun, Yu Kyung Lee and Ja Seung Koo
    Citation: Journal of Translational Medicine 2016 14:173
  29. MicroRNAs have the potential as diagnostic biomarkers and therapeutic targets in autoimmune diseases. However, very limited studies have evaluated the expression of microRNA profile in thyroid gland related to...

    Authors: Jin Zhu, Yuehua Zhang, Weichen Zhang, Wei Zhang, Linni Fan, Lu Wang, Yixiong Liu, Shasha Liu, Ying Guo, Yingmei Wang, Jun Yi, Qingguo Yan, Zhe Wang and Gaosheng Huang
    Citation: Journal of Translational Medicine 2016 14:166
  30. Adjuvant chemotherapy in patients with resected esophageal squamous cell cancer (ESCC) remains controversial for its uncertain role in improving overall survival (OS). Nucleotide excision repair (NER) removes ...

    Authors: Fei Zhou, Meiling Zhu, Mengyun Wang, Lixin Qiu, Lei Cheng, Ming Jia, Jiaqing Xiang and Qingyi Wei
    Citation: Journal of Translational Medicine 2016 14:154
  31. Diabetes testing using saliva, rather than blood and urine, could facilitate diabetes screening in public spaces. We previously identified 1,5-anhydro-d-glucitol (1,5-AG) in saliva as a diabetes biomarker. The Gl...

    Authors: Anna Halama, Michal Kulinski, Sara Abdul Kader, Noothan J. Satheesh, Abdul Badi Abou-Samra, Karsten Suhre and Ramzi M. Mohammad
    Citation: Journal of Translational Medicine 2016 14:140
  32. The prognosis of children with metastatic stage 4 neuroblastoma (NB) has remained poor in the past decade.

    Authors: Daniela Formicola, Giuseppe Petrosino, Vito Alessandro Lasorsa, Piero Pignataro, Flora Cimmino, Simona Vetrella, Luca Longo, Gian Paolo Tonini, André Oberthuer, Achille Iolascon, Matthias Fischer and Mario Capasso
    Citation: Journal of Translational Medicine 2016 14:142
  33. Esophageal squamous cell carcinoma (ESCC) is one of the most aggressively malignant tumors with dismal prognosis. Profilin 2 (PFN2) is an actin-binding protein that regulates the dynamics of actin polymerizati...

    Authors: Xiao-bin Cui, Shu-mao Zhang, Yue-xun Xu, Hong-wei Dang, Chun-xia Liu, Liang-hai Wang, Lan Yang, Jian-ming Hu, Wei-hua Liang, Jin-fang Jiang, Na Li, Yong Li, Yun-zhao Chen and Feng Li
    Citation: Journal of Translational Medicine 2016 14:137
  34. There is an unmet need for more efficient patient stratification for receiving trastuzumab in the metastatic breast cancer (mBC) setting, since only part of such patients benefit from the addition of this agen...

    Authors: Helen Gogas, Vassiliki Kotoula, Zoi Alexopoulou, Christos Christodoulou, Ioannis Kostopoulos, Mattheos Bobos, Georgia Raptou, Elpida Charalambous, Eleftheria Tsolaki, Ioannis Xanthakis, George Pentheroudakis, Angelos Koutras, Dimitrios Bafaloukos, Pavlos Papakostas, Gerasimos Aravantinos, Amanda Psyrri…
    Citation: Journal of Translational Medicine 2016 14:136
  35. The receptor for activated C kinase 1 (RACK1) is involved in various cancers, but its roles in nasopharyngeal carcinoma (NPC) have not yet been fully elucidated.

    Authors: Hong Peng, Ping-Gui Gong, Jin-Bang Li, Long-Mei Cai, Le Yang, Yun-yi Liu, Kai-tai Yao and Xin Li
    Citation: Journal of Translational Medicine 2016 14:131
  36. Podocalyxin-like 1 (PODXL) is an anti-adhesive transmembrane protein that has been demonstrated to be an independent factor of poor prognosis in colorectal cancer (CRC). The gene encoding PODXL is located to c...

    Authors: Anna H. Larsson, Sophie Lehn, Sakarias Wangefjord, Emelie Karnevi, Eugenia Kuteeva, Magnus Sundström, Björn Nodin, Mathias Uhlén, Jakob Eberhard, Helgi Birgisson and Karin Jirström
    Citation: Journal of Translational Medicine 2016 14:128
  37. The oncogenic role of the fibroblast growth factor receptor (FGFR) has been recognized in a number of different cancer types. However, the prognostic significance of FGFRs has not been elucidated yet in cervic...

    Authors: Chel Hun Choi, Joon-Yong Chung, Jae-Hoon Kim, Byoung-Gie Kim and Stephen M. Hewitt
    Citation: Journal of Translational Medicine 2016 14:124
  38. Circulating microRNAs (miRNAs) emerge as novel biomarkers in cardiovascular diseases. Diagnosing acute pulmonary embolism (PE) remains challenging due to a diverse clinical presentation and the lack of specifi...

    Authors: Thorsten Kessler, Jeanette Erdmann, Baiba Vilne, Petra Bruse, Volkhard Kurowski, Patrick Diemert, Heribert Schunkert and Hendrik B. Sager
    Citation: Journal of Translational Medicine 2016 14:120
  39. Annexins are Ca2+-regulated phospholipid-binding proteins that play an important role in the cell life cycle, exocytosis, and apoptosis. Annexin A11 is one of the oldest vertebrate annexins that has a crucial rol...

    Authors: Mehdi Mirsaeidi, Sanaz Gidfar, Ann Vu and Dean Schraufnagel
    Citation: Journal of Translational Medicine 2016 14:89
  40. S100A13 and high mobility group A (HMGA1) are known to play essential roles in the carcinogenesis and progression of cancer. However, the correlation between S100A13 and HMGA1 during cancer progression is not...

    Authors: Jing Zhong, Chang Liu, Ya-jun Chen, Qing-hai Zhang, Jing Yang, Xuan Kang, Si-Rui Chen, Ge-bo Wen, Xu-yu Zu and Ren-xian Cao
    Citation: Journal of Translational Medicine 2016 14:80
  41. Low back pain and sciatica caused by intervertebral disc (IVD) disease are associated with inflammatory responses. The cytokine interleukin 17 (IL-17) is elevated in herniated and degenerated IVD tissues and a...

    Authors: Jing-kun Li, Lin Nie, Yun-peng Zhao, Yuan-qiang Zhang, Xiaoqing Wang, Shuai-shuai Wang, Yi Liu, Hua Zhao and Lei Cheng
    Citation: Journal of Translational Medicine 2016 14:77
  42. Beta-2-microglobulin (B2M), a light chain subunit of the major histocompatibility complex (MHC) class I complex, has been implicated in tumorigenesis. However, whether it is expressed in different epithelial-t...

    Authors: Wenwen Sun, Lu Gui, Xulei Zuo, Lingyun Zhang, Daibing Zhou, Xiaoling Duan, Weimin Ren and Guoxiong Xu
    Citation: Journal of Translational Medicine 2016 14:75
  43. Despite the efficacy of decitabine treatment in myelodysplastic syndrome (MDS), no definite predictor of response is known. In this study, we investigated whether the expression levels of human equilibrative n...

    Authors: Lingyun Wu, Wenhui Shi, Xiao Li, Chunkang Chang, Feng Xu, Qi He, Dong Wu, Jiying Su, Liyu Zhou, Luxi Song, Chao Xiao and Zheng Zhang
    Citation: Journal of Translational Medicine 2016 14:66
  44. C14orf166 (chromosome 14 open reading frame 166) plays a crucial role in some tumors, but its role in bladder cancer hasn’t been explored.

    Authors: Mingkun Chen, Yunlin Ye, Baojia Zou, Suping Guo, Fangjian Zhou, Keshi Lu, Jianye Liu, Zhenzhou Xu, Hui Han, Zhuowei Liu, Yonghong Li, Kai Yao, Cundong Liu and Zike Qin
    Citation: Journal of Translational Medicine 2016 14:55
  45. Urine based assays that can non-invasively detect bladder cancer (BCa) have the potential to reduce unnecessary and invasive procedures. The purpose of this study was to develop a multiplex immunoassay that ca...

    Authors: Yoshiko Shimizu, Hideki Furuya, Peter Bryant Greenwood, Owen Chan, Yunfeng Dai, Mark D. Thornquist, Steve Goodison and Charles J. Rosser
    Citation: Journal of Translational Medicine 2016 14:31
  46. Mitochondrial dysfunction has been hypothesized to occur in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), a disease characterized by fatigue, cognitive difficulties, pain, malaise, and exercise ...

    Authors: Paul Billing-Ross, Arnaud Germain, Kaixiong Ye, Alon Keinan, Zhenglong Gu and Maureen R. Hanson
    Citation: Journal of Translational Medicine 2016 14:19
  47. The challenging diagnosis and poor prognosis of cholangiocarcinoma require the determination of biomarkers. Autoantibodies could be used in the clinic as diagnostic markers for the early detection of tumours. ...

    Authors: Mohammad Zahid Mustafa, Viet Hung Nguyen, François Le Naour, Eleonora De Martin, Elvire Beleoken, Catherine Guettier, Catherine Johanet, Didier Samuel, Jean-Charles Duclos-Vallee and Eric Ballot
    Citation: Journal of Translational Medicine 2016 14:17
  48. Cabozantinib is an orally available inhibitor of tyrosine kinases including VEGFR2 and c-MET. We performed a post hoc analysis to find associations between select plasma biomarkers and treatment response in p...

    Authors: Raya Leibowitz-Amit, Melania Pintilie, Leila Khoja, Arun A. Azad, Raanan Berger, A. Douglas Laird, Dana T. Aftab, Kim N. Chi and Anthony M. Joshua
    Citation: Journal of Translational Medicine 2016 14:12

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