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Disease biomarkers

Section edited by Xiangdong Wang

This section aims to bridge the identification and validation of discovered gene or protein-based, network or dynamic network biomarkers with human diseases, patient phenotypes, or clinical applications, and accelerate the development of human disease-specific biomarkers for the early diagnosis, monitoring, evaluation, and prediction of diseases. Conditions including cancers, cardiovascular and metabolic diseases will be the focus of study. This section will promote the innovation and development of disease-specific biomarkers by integrating multidisciplinary aspects of science.

Studies considered for publication include those regarding the development of advanced biotechnologies for biomarker discovery and development, identifying biomarkers associated with the early detection of diseases, monitoring of disease severity and duration as well as patient responses to therapies, prediction of patient outcomes and the evaluation, regulation and ethics of disease biomarkers.

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  1. The major cancer related mortality is caused by metastasis and invasion. It is important to identify genes regulating metastasis and invasion in order to curtail metastatic spread of cancer cells.

    Authors: Chih-Hao Chang, Tan-Chi Fan, Jyh-Cherng Yu, Guo-Shiou Liao, You-Chin Lin, Arthur Chun-Chieh Shih, Wen-Hsiung Li and Alice Lin-Tsing Yu

    Citation: Journal of Translational Medicine 2014 12:257

    Content type: Research

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  2. Human cystatin C (HCC) is a potential biomarker for tubular damage and impaired renal function. It is difficult to obtain efficient paired monoclonal antibodies against HCC with low molecular to meet the requi...

    Authors: Renren Jiang, Chao Xu, Xiaoli Zhou, Tianhao Wang and Gang Yao

    Citation: Journal of Translational Medicine 2014 12:205

    Content type: Research

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  3. Platinum-based chemotherapy improves survival among patients with non-small cell lung cancer (NSCLC), but the efficiency is limited due to resistance. In this study, we aimed to identify the expression of Auro...

    Authors: Jie Xu, Cai-feng Yue, Wei-hua Zhou, Yuan-min Qian, Yan Zhang, Shao-wu Wang, An-wen Liu and Quentin Liu

    Citation: Journal of Translational Medicine 2014 12:200

    Content type: Research

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  4. Toll-like receptor 4 (TLR4), a lipopolysaccharide (LPS) receptor complex signal-transducing molecule, plays a crucial role in sensing LPS from gram-negative bacteria. TLR4 signaling pathway activation by LPS p...

    Authors: Ashham Mansur, Luisa von Gruben, Aron F Popov, Maximilian Steinau, Ingo Bergmann, Daniel Ross, Michael Ghadimi, Tim Beissbarth, Martin Bauer and José Hinz

    Citation: Journal of Translational Medicine 2014 12:177

    Content type: Research

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  5. Overall cure rates in acute myeloid leukemia (AML) continue to range between 60-65% with disease relapse being a major cause of mortality. The PI3K-Akt-mTOR kinase pathway plays a vital role in pro-survival si...

    Authors: Himalee Sabnis, Heath L Bradley, Silvia T Bunting, Todd M Cooper and Kevin D Bunting

    Citation: Journal of Translational Medicine 2014 12:166

    Content type: Methodology

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  6. HER2 status assessment is a prerequisite for the establishment of an appropriate treatment strategy in gastric cancer. Gastric cancers are very heterogeneous and separate evaluations of gene amplification and ...

    Authors: Dominique Werner, Achim Battmann, Kristina Steinmetz, Tobin Jones, Tiffany Lamb, Michele Martinez, Hans-Michael Altmannsberger and Salah-Eddin Al-Batran

    Citation: Journal of Translational Medicine 2014 12:160

    Content type: Research

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  7. Lung adenocarcinoma is a heterogernous disease that creates challenges for classification and management. The purpose of this study is to identify specific miRNA markers closely associated with the survival of...

    Authors: Xuelian Li, Yunrui Shi, Zhihua Yin, Xiaoxia Xue and Baosen Zhou

    Citation: Journal of Translational Medicine 2014 12:159

    Content type: Research

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  8. Telomere dysfunction is important in carcinogenesis, and recently, stathmin and elongation factor 1α (EF1α) were reported to be up-regulated in telomere dysfunctional mice.

    Authors: Ei Yong Ahn, Jeong Eun Yoo, Hyungjin Rhee, Myung Soo Kim, Junjeong Choi, Jung Eun Ko, Jee San Lee and Young Nyun Park

    Citation: Journal of Translational Medicine 2014 12:154

    Content type: Research

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  9. Personalized cancer treatment relies on the accurate detection of actionable genomic aberrations in tumor cells. Circulating tumor cells (CTCs) could provide an alternative genetic resource for diagnosis; howe...

    Authors: Masaru Watanabe, Masakuni Serizawa, Takeshi Sawada, Kazuo Takeda, Toshiaki Takahashi, Nobuyuki Yamamoto, Fumiaki Koizumi and Yasuhiro Koh

    Citation: Journal of Translational Medicine 2014 12:143

    Content type: Methodology

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  10. In recent years, it is recognized that acquired immunity is controlled by regulatory T cell (Treg). Since fundamental pathophysiological changes of allergy are mainly caused by hyperresponsiveness of immune sy...

    Authors: Huiyun Zhang, Hui Kong, Xiaoning Zeng, Lianyi Guo, Xiaoyun Sun and Shaoheng He

    Citation: Journal of Translational Medicine 2014 12:125

    Content type: Review

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  11. Understanding the pathogenic mechanism of pancreatic cancer associated diabetes (PCDM) might help yield biomarkers for the early diagnosis of pancreatic cancer (PC) from population with new-onset diabetes. In ...

    Authors: Langping Tan, Xiao Ye, Yu Zhou, Min Yu, Zhiqiang Fu, Ruiwan Chen, Baoxiong Zhuang, Bing Zeng, Huilin Ye, Wenchao Gao, Qing Lin, Zhihua Li, Quanbo Zhou and Rufu Chen

    Citation: Journal of Translational Medicine 2014 12:92

    Content type: Research

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  12. The polymeric immunoglobulin receptor (PIGR) has been proposed to be a candidate prognostic biomarker in a few cancer forms, and one previous study reported that reduced PIGR expression signifies more aggressi...

    Authors: Richard Fristedt, Alexander Gaber, Charlotta Hedner, Björn Nodin, Mathias Uhlén, Jakob Eberhard and Karin Jirström

    Citation: Journal of Translational Medicine 2014 12:83

    Content type: Research

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  13. Yin Yang 1 (YY1) is a transcription factor that regulates diverse biological processes and increasing recognized to have important roles in carcinogenesis. The function and clinical significance of YY1 in gast...

    Authors: Wei Kang, Joanna HM Tong, Anthony WH Chan, Junhong Zhao, Yujuan Dong, Shiyan Wang, Weiqin Yang, Frankie MC Sin, Simon SM Ng, Jun Yu, Alfred SL Cheng and Ka Fai To

    Citation: Journal of Translational Medicine 2014 12:80

    Content type: Research

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  14. Betacellulin (BTC), a member of the epidermal growth factor (EGF) family, binds and activates ErbB1 and ErbB4 homodimers. BTC was expressed in tumors and involved in tumor growth progression. CXCL8 (interleuki...

    Authors: Lin Shi, Lingyan Wang, Beibei Wang, Sanda Maria Cretoiu, Qun Wang, Xiangdong Wang and Chengshui Chen

    Citation: Journal of Translational Medicine 2014 12:70

    Content type: Research

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  15. There are diverse molecules present in blood plasma that regulate immune functions and also present a potential source of disease biomarkers and therapeutic targets. Genome-wide profiling has become a powerful...

    Authors: Prasong Khaenam, Darawan Rinchai, Matthew C Altman, Laurent Chiche, Surachat Buddhisa, Chidchamai Kewcharoenwong, Duangchan Suwannasaen, Michael Mason, Elizabeth Whalen, Scott Presnell, Wattanachai Susaengrat, Kimberly O’Brien, Quynh-Ahn Nguyen, Vivian Gersuk, Peter S Linsley, Ganjana Lertmemongkolchai…

    Citation: Journal of Translational Medicine 2014 12:65

    Content type: Research

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  16. Hypoxic pulmonary artery hypertension (PAH) as a severe pulmonary disease is characterized by changes of pulmonary vascular reconstruction. Mitochondrial ATP-sensitive potassium channel (mitoKATP) was considered ...

    Authors: Li Dong, Yuping Li, HongLing Hu, Lin Shi, Junjie Chen, Beibei Wang, Chaolei Chen, Haiping Zhu, Yunlei Li, Qiu Li, Liping Zhang and Chengshui Chen

    Citation: Journal of Translational Medicine 2014 12:39

    Content type: Research

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  17. The effects of berberine on the metastatic potential of lung cancer cells and its underlying mechanisms have not been fully elucidated. Since epithelial-to-mesenchymal transition is a cellular process associat...

    Authors: Hui-wei Qi, Ling-yan Xin, Xin Xu, Xian-xiu Ji and Li-hong Fan

    Citation: Journal of Translational Medicine 2014 12:22

    Content type: Research

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  18. E1694 tested GM2-KLH-QS21 vaccine versus high-dose interferon-α2b (HDI) as adjuvant therapy for operable stage IIB-III melanoma. We tested banked serum specimens from patients in the vaccine arm of E1694 for p...

    Authors: Ahmad A Tarhini, Yan Lin, Oladapo Yeku, William A LaFramboise, Madeeha Ashraf, Cindy Sander, Sandra Lee and John M Kirkwood

    Citation: Journal of Translational Medicine 2014 12:19

    Content type: Research

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  19. Golgi phosphoprotein 3 (GOLPH3) has been validated as a potent oncogene involved in the progression of many types of solid tumors, and its overexpression is associated with poor clinical outcome in many cancer...

    Authors: Zaozao Wang, Beihai Jiang, Lei Chen, Jiabo Di, Ming Cui, Maoxing Liu, Yiyuan Ma, Hong Yang, Jiadi Xing, Chenghai Zhang, Zhendan Yao, Nan Zhang, Bin Dong, Jiafu Ji and Xiangqian Su

    Citation: Journal of Translational Medicine 2014 12:15

    Content type: Research

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  20. Nasopharyngeal carcinoma (NPC) is a solid tumor of the head and neck. Multimodal therapy is highly effective when NPC is detected early. However, due to the location of the tumor and the absence of clinical si...

    Authors: Jordan L Plieskatt, Gabriel Rinaldi, Yanjung Feng, Paul H Levine, Samantha Easley, Elizabeth Martinez, Salman Hashmi, Nader Sadeghi, Paul J Brindley, Jeffrey M Bethony and Jason P Mulvenna

    Citation: Journal of Translational Medicine 2014 12:3

    Content type: Research

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  21. Hypermethylation in the promoter regions is associated with the suppression of gene expression and has been considered a potential molecular marker for several tumor types, including head and neck squamous cel...

    Authors: Marianna Marconato Rettori, Ana Carolina de Carvalho, Ana Luiza Bomfim Longo, Cleyton Zanardo de Oliveira, Luiz Paulo Kowalski, André Lopes Carvalho and André Luiz Vettore

    Citation: Journal of Translational Medicine 2013 11:316

    Content type: Research

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  22. We have previously demonstrated an aberrant overexpression of the microtubule-associated protein TPX2 in colon cancer using a genome-wide gene expression profiling analysis. Here, we aim to investigate its exp...

    Authors: Ping Wei, Nu Zhang, Ye Xu, Xinxiang Li, Debing Shi, Yuwei Wang, Dawei Li and Sanjun Cai

    Citation: Journal of Translational Medicine 2013 11:313

    Content type: Research

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  23. Early disease detection with a minimally invasive screening test will significantly increase effectiveness and decrease the cost of treatment. Here we propose a framework of a novel approach – Universal Screen...

    Authors: Kira S Sheinerman, Vladimir G Tsivinsky and Samuil R Umansky

    Citation: Journal of Translational Medicine 2013 11:304

    Content type: Research

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  24. INI1 (Integrase interactor 1), also known as SMARCB1, is the most studied subunit of chromatin remodelling complexes. Its role in colorectal tumorigenesis is not known.

    Authors: Massimo Pancione, Andrea Remo, Caterina Zanella, Lina Sabatino, Arturo Di Blasi, Carmelo Laudanna, Laura Astati, Michele Rocco, Delfina Bifano, Paolo Piacentini, Laura Pavan, Alberto Purgato, Filippo Greco, Alberto Talamini, Andrea Bonetti, Michele Ceccarelli…

    Citation: Journal of Translational Medicine 2013 11:297

    Content type: Research

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  25. The ability to forecast whether a wound will heal after closure without further debridement(s), would provide substantial benefits to patients with severe extremity trauma.

    Authors: Brett A Chromy, Angela Eldridge, Jonathan A Forsberg, Trevor S Brown, Benjamin C Kirkup, Crystal Jaing, Nicholas A Be, Eric Elster and Paul A Luciw

    Citation: Journal of Translational Medicine 2013 11:281

    Content type: Research

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  26. Steadily high melanoma mortality rates urge for the availability of novel biomarkers with a more personalized ability to predict melanoma clinical outcomes. Germline risk variants are promising candidates for ...

    Authors: Justin Rendleman, Shulian Shang, Christine Dominianni, Jerry F Shields, Patrick Scanlon, Christina Adaniel, Alexis Desrichard, Michelle Ma, Richard Shapiro, Russell Berman, Anna Pavlick, David Polsky, Yongzhao Shao, Iman Osman and Tomas Kirchhoff

    Citation: Journal of Translational Medicine 2013 11:279

    Content type: Research

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  27. Paxillin (PXN) has been found to be aberrantly regulated in various malignancies and involved in tumor growth and invasion. The clinicopathological and prognostic significance of PXN in gastric cancer is still...

    Authors: Dong-liang Chen, Zhi-qiang Wang, Chao Ren, Zhao-lei Zeng, De-shen Wang, Hui-yan Luo, Feng Wang, Miao-zhen Qiu, Long Bai, Dong-sheng Zhang, Feng-hua Wang, Yu-hong Li and Rui-hua Xu

    Citation: Journal of Translational Medicine 2013 11:277

    Content type: Research

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  28. Increasing evidence has suggested that dysregulation of certain microRNAs (miRNAs) may contribute to human disease including carcinogenesis and tumor metastasis in human. miR-124-3p is down-regulated in variou...

    Authors: Xianglai Xu, Shiqi Li, Yiwei Lin, Hong Chen, Zhenghui Hu, Yeqing Mao, Xin Xu, Jian Wu, Yi Zhu, Xiangyi Zheng, Jindan Luo and Liping Xie

    Citation: Journal of Translational Medicine 2013 11:276

    Content type: Research

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  29. Colorectal cancer (CRC) is the most common digestive system malignancy. The molecular events involved in the development and progression of CRC remain unclear. Recently, more and more evidences have showed tha...

    Authors: Limin Long, Guoqing Huang, Hongyi Zhu, Yonghong Guo, Youshuo Liu and Jirong Huo

    Citation: Journal of Translational Medicine 2013 11:275

    Content type: Research

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  30. The La-related protein 1 (LARP1) has been found to be a RNA binding protein and was related to spermatogenesis, embryogenesis and cell-cycle progression. The aim of this study was to investigate the prognostic...

    Authors: Chan Xie, Li Huang, Shibin Xie, Dongying Xie, Genlin Zhang, Peipei Wang, Liang Peng and Zhiliang Gao

    Citation: Journal of Translational Medicine 2013 11:272

    Content type: Research

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  31. Alcohol consumption is a major cause of liver disease in humans. The use and monitoring of biomarkers associated with early, pre-clinical stages of alcohol-induced liver disease (pre-ALD) could facilitate diag...

    Authors: Heng-Hong Li, Kathryn Doiron, Andrew D Patterson, Frank J Gonzalez and Albert J Fornace Jr

    Citation: Journal of Translational Medicine 2013 11:266

    Content type: Research

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  32. Atherosclerosis is the main cause of morbidity and mortality in Western countries and carotid plaque rupture is associated to acute events and responsible of 15-20% of all ischemic strokes. Several proteomics ...

    Authors: Silvia Rocchiccioli, Gualtiero Pelosi, Silvia Rosini, Michele Marconi, Federica Viglione, Lorenzo Citti, Mauro Ferrari, Maria Giovanna Trivella and Antonella Cecchettini

    Citation: Journal of Translational Medicine 2013 11:260

    Content type: Research

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  33. Matrix metalloproteinases can promote invasion and metastasis, which are very frequent in renal cell carcinoma even at the time of diagnosis. Knowing the reversion-inducing cysteine-rich protein with Kazal mot...

    Authors: Anja Rabien, Carsten Stephan, Ergin Kilic, Wilko Weichert, Glen Kristiansen, Kurt Miller, Klaus Jung and Andreas Erbersdobler

    Citation: Journal of Translational Medicine 2013 11:258

    Content type: Research

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  34. Although the potential of biomarkers to aid in early detection of colorectal cancer (CRC) is recognized and numerous biomarker candidates have been reported in the literature, to date only few molecular marker...

    Authors: Stine Buch Thorsen, Martin Lundberg, Andrea Villablanca, Sarah Louise T Christensen, Kirstine Christensen Belling, Birgitte Sander Nielsen, Mick Knowles, Nick Gee, Hans Jørgen Nielsen, Nils Brünner, Ib Jarle Christensen, Simon Fredriksson, Jan Stenvang and Erika Assarsson

    Citation: Journal of Translational Medicine 2013 11:253

    Content type: Research

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  35. Chronic Fatigue Syndrome (CFS) is a severe, systemic illness characterized by persistent, debilitating and medically unexplained fatigue. The etiology and pathophysiology of CFS remains obscure, and diagnosis ...

    Authors: Federica Ciregia, Laura Giusti, Ylenia Da Valle, Elena Donadio, Arianna Consensi, Camillo Giacomelli, Francesca Sernissi, Pietro Scarpellini, Fabrizio Maggi, Antonio Lucacchini and Laura Bazzichi

    Citation: Journal of Translational Medicine 2013 11:243

    Content type: Research

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  36. The incidence and mortality of hepatitis C virus (HCV)-induced hepatocellular carcinoma (HCC) is higher in African Americans (AA) than other racial/ethnic groups in the U.S., but the reasons for this disparity...

    Authors: Simon T Dillon, Manoj K Bhasin, Xiaoxing Feng, David W Koh and Sayed S Daoud

    Citation: Journal of Translational Medicine 2013 11:239

    Content type: Research

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  37. Due to known limitations of liver biopsy, reliable non-invasive serum biomarkers for chronic liver diseases are needed. We performed serum peptidomics for such investigation in compensated chronic hepatitis B ...

    Authors: Ming-Yi Xu, Xiao-Fang Jia, Ying Qu, Rui-Dan Zheng, Zheng-Hong Yuan, Hong-Lei Weng, Steven Dooley, Xing-Peng Wang, Li-Jun Zhang and Lun-Gen Lu

    Citation: Journal of Translational Medicine 2013 11:234

    Content type: Research

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  38. Long non-coding RNAs (lncRNAs) are prevalently transcribed in the genome yet their potential roles in human cancers are not well understood. The aim of the present study was to determine the lncRNA expression ...

    Authors: Haojun Song, Weiliang Sun, Guoliang Ye, Xiaoyun Ding, Zhong Liu, Sijie Zhang, Tian Xia, Bingxiu Xiao, Yang Xi and Junming Guo

    Citation: Journal of Translational Medicine 2013 11:225

    Content type: Research

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  39. The control of Mycobacterium tuberculosis (Mtb) infection begins with the recognition of mycobacterial structural components by toll like receptors (TLRs) and other pattern recognition receptors. Our objective wa...

    Authors: Diana Torres-García, Alfredo Cruz-Lagunas, Ma Cecilia García-Sancho Figueroa, Rosario Fernández-Plata, Renata Baez-Saldaña, Criselda Mendoza-Milla, Rodrigo Barquera, Aida Carrera-Eusebio, Salomón Ramírez-Bravo, Lizeth Campos, Javier Angeles, Gilberto Vargas-Alarcón, Julio Granados, Radha Gopal, Shabaana A Khader, Edmond J Yunis…

    Citation: Journal of Translational Medicine 2013 11:220

    Content type: Research

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  40. Osteoporosis is characterised by low bone mass and structural deterioration of bone tissue, resulting in increased fragility and susceptibility to fracture. Osteoporotic fractures are a significant cause of mo...

    Authors: Gillian Wheater, Mohsen Elshahaly, Stephen P Tuck, Harish K Datta and Jacob M van Laar

    Citation: Journal of Translational Medicine 2013 11:201

    Content type: Review

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  41. Increasing evidence indicates that deregulation of microRNAs (miRNAs) is involved in tumorigenesis. Downregulation of microRNA-503 has been observed in various types of diseases, including cancer. However, the...

    Authors: Fenqiang Xiao, Wu zhang, Liming Chen, Fei Chen, Haiyang Xie, Chunyang Xing, Xiaobo Yu, Songming Ding, Kangjie Chen, Haijun Guo, Jun Cheng, Shusen Zheng and Lin Zhou

    Citation: Journal of Translational Medicine 2013 11:195

    Content type: Research

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  42. After hematopoietic stem cell transplantation (HSCT) T- and B-cell reconstitution from primary lymphoid organs are a prerequisite for an effective early lymphocyte reconstitution and a long-term survival for a...

    Authors: Angela Mensen, Christoph Ochs, Andrea Stroux, Friedrich Wittenbecher, Martin Szyska, Luisa Imberti, Simon Fillatreau, Lutz Uharek, Renate Arnold, Bernd Dörken, Andreas Thiel, Carmen Scheibenbogen and Il-Kang Na

    Citation: Journal of Translational Medicine 2013 11:188

    Content type: Research

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  43. Hypoxia inducible factor-1 alpha (HIF-1α), induced by tumor hypoxia, regulates tumor cell metabolism and metastasis by up-regulation of c-Met, carbonic anhydrase 9 (CA9) and glucose transporter 1 (GLUT1). The ...

    Authors: Bo Wook Kim, Hanbyoul Cho, Joon-Yong Chung, Catherine Conway, Kris Ylaya, Jae-Hoon Kim and Stephen M Hewitt

    Citation: Journal of Translational Medicine 2013 11:185

    Content type: Research

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  44. The aim of the present study was to investigate within ovarian carcinoma and normal ovarian biopsies the gene expression of multiple secretoglobin family members relative to mammaglobin B, which we previously ...

    Authors: Eliana Bignotti, Renata A Tassi, Stefano Calza, Antonella Ravaggi, Elisa Rossi, Carla Donzelli, Paola Todeschini, Chiara Romani, Elisabetta Bandiera, Laura Zanotti, Mario Carnazza, Francesco Quadraro, Germana Tognon, Enrico Sartori, Sergio Pecorelli, Dana M Roque…

    Citation: Journal of Translational Medicine 2013 11:162

    Content type: Research

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  45. The cell division cycle 20 homolog (CDC20) is an essential cofactor of the anaphase-promoting complex (APC/C). CDC20 overexpression has been detected in many types of human cancers; however, its clinical role ...

    Authors: Wen-jing Wu, Kai-shun Hu, De-shen Wang, Zhao-lei Zeng, Dong-sheng Zhang, Dong-liang Chen, Long Bai and Rui-hua Xu

    Citation: Journal of Translational Medicine 2013 11:142

    Content type: Research

    Published on:

  46. The aim of this study was to analyze the expression of protein tyrosine kinase 6 (PTK6) in nasopharyngeal carcinoma (NPC) samples, and to identify whether PTK6 can serve as a biomarker for the diagnosis and pr...

    Authors: Li-na Liu, Pei-yu Huang, Zhi-rui Lin, Li-juan Hu, Jian-zhong Liang, Man-zhi Li, Lin-quan Tang, Mu-sheng Zeng, Qian Zhong and Bo-hang Zeng

    Citation: Journal of Translational Medicine 2013 11:140

    Content type: Research

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  47. Gadd45a is a member of the Gadd45 family of genes that are known stress sensors. Gadd45a has been shown to serve as an effector in oncogenic stress in breast carcinogenesis in murine models. The present study ...

    Authors: Jennifer S Tront, Alliric Willis, Yajue Huang, Barbara Hoffman and Dan A Liebermann

    Citation: Journal of Translational Medicine 2013 11:131

    Content type: Research

    Published on:

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