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Computational modelling and Epidemiology

Section edited by Michael N. Liebman and Sabrina Molinaro

This section aims to allow rapid communication of methods and results that utilize computational modeling and epidemiologic approaches in translational medicine. The focus will be on population-based studies that extend towards more molecular level analysis. 

Submission of studies involving methods development is encouraged where actual application and results can be shown in the healthcare and life sciences domains. Among the approaches highlighted in this section are data-mining for health impact, data modeling, health record system design, applications of epidemiologic analysis, public policy evaluation, hypothesis evaluation and testing, risk assessment in healthcare and life sciences. These articles will describe the perspective on translational medicine where the approach and results reflect the computational modeling and epidemiologic aspects of this emerging area of research.

Featured articles

Impact of lockdown on Covid-19 case fatality rate and viral mutations spread in 7 countries in Europe and North America

Research | Maria Pachetti et al

Analysis of SARS-CoV-2 RNA-dependent RNA polymerase as a potential therapeutic drug target using a computational approach

Research | Syed Ovais Aftab et al


The effects of statins on dental and oral health: a review of preclinical and clinical studies

Review | Shabnam Tahamtan et al

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  1. Epilepsy is a prevalent neurological disorder in which seizures cause recurrent episodes of unconsciousness or muscle convulsions, seriously affecting the patient’s work, quality of life, and health and safety...

    Authors: Rong Zhu, Wen-xin Pan, Jin-xing Liu and Jun-liang Shang
    Citation: Journal of Translational Medicine 2024 22:895
  2. Single-cell technology depicts integrated tumor profiles including both tumor cells and tumor microenvironments, which theoretically enables more robust diagnosis than traditional diagnostic standards based on...

    Authors: Dao-Han Zhang, Chen Liang, Shu-Yang Hu, Xiao-Yong Huang, Lei Yu, Xian-Long Meng, Xiao-Jun Guo, Hai-Ying Zeng, Zhen Chen, Lv Zhang, Yan-Zi Pei, Mu Ye, Jia-Bin Cai, Pei-Xin Huang, Ying-Hong Shi, Ai-Wu Ke…
    Citation: Journal of Translational Medicine 2024 22:883
  3. In the management of complex diseases, the strategic adoption of combination therapy has gained considerable prominence. Combination therapy not only holds the potential to enhance treatment efficacy but also ...

    Authors: Tingting Li, Long Xiao, Haigang Geng, Anqi Chen and Yue-Qing Hu
    Citation: Journal of Translational Medicine 2024 22:873
  4. Treatment strategy against immune-related adverse events (irAEs) induced by immune checkpoint inhibitors (ICIs) frequently requires other immunosuppressive agents. Tofacitinib is a rapidly acting JAK-STAT inhi...

    Authors: Qing Liu, Mengling Liu, Zhiguo Zou, Jinyi Lin, Ningping Zhang, Lin Zhao, Jiahua Zhou, Haojie Zhou, Xin Zhou, Xiaodong Jiao, Yiyi Yu and Tianshu Liu
    Citation: Journal of Translational Medicine 2024 22:803
  5. Cathepsin C (CTSC) is a lysosomal cysteine protease constitutively expressed at high levels in the lung, kidney, liver, and spleen. It plays a key role in the activation of serine proteases in cytotoxic T cell...

    Authors: Chakriya Chitsamankhun, Nutwara Siritongtaworn, B. P. J. Fournier, Kanokwan Sriwattanapong, Thanakorn Theerapanon, Lakshman Samaranayake and Thantrira Porntaveetus
    Citation: Journal of Translational Medicine 2024 22:777
  6. Acute respiratory distress syndrome (ARDS) after cardiac surgery is a severe respiratory complication with high mortality and morbidity. Traditional clinical approaches may lead to under recognition of this he...

    Authors: Hang Zhang, Dewei Qian, Xiaomiao Zhang, Peize Meng, Weiran Huang, Tongtong Gu, Yongliang Fan, Yi Zhang, Yuchen Wang, Min Yu, Zhongxiang Yuan, Xin Chen, Qingnan Zhao and Zheng Ruan
    Citation: Journal of Translational Medicine 2024 22:772
  7. Temporal lobe epilepsy (TLE) is associated with abnormal dynamic functional connectivity patterns, but the dynamic changes in brain activity at each time point remain unclear, as does the potential molecular m...

    Authors: Lu Qin, Qin Zhou, Yuting Sun, Xiaomin Pang, Zirong Chen and Jinou Zheng
    Citation: Journal of Translational Medicine 2024 22:763
  8. Decoding human genomic sequences requires comprehensive analysis of DNA sequence functionality. Through computational and experimental approaches, researchers have studied the genotype-phenotype relationship a...

    Authors: Duo Du, Fan Zhong and Lei Liu
    Citation: Journal of Translational Medicine 2024 22:756
  9. Severe heart failure (HF) has a higher mortality during vulnerable period while targeted predictive tools, especially based on drug exposures, to accurately assess its prognoses remain largely unexplored. Ther...

    Authors: Yu Guo, Fang Yu, Fang-Fang Jiang, Sun-Jun Yin, Meng-Han Jiang, Ya-Jia Li, Hai-Ying Yang, Li-Rong Chen, Wen-Ke Cai and Gong-Hao He
    Citation: Journal of Translational Medicine 2024 22:743
  10. Accurate survival prediction for Non-Small Cell Lung Cancer (NSCLC) patients remains a significant challenge for the scientific and clinical community despite decades of advanced analytics. Addressing this cha...

    Authors: Chao Fang, Gustavo Alonso Arango Argoty, Ioannis Kagiampakis, Mohammad Hassan Khalid, Etai Jacob, Krishna C. Bulusu and Natasha Markuzon
    Citation: Journal of Translational Medicine 2024 22:726
  11. Intraoperative Hypotension (IOH) poses a substantial risk during surgical procedures. The integration of Artificial Intelligence (AI) in predicting IOH holds promise for enhancing detection capabilities, provi...

    Authors: Ida Mohammadi, Shahryar Rajai Firouzabadi, Melika Hosseinpour, Mohammadhosein Akhlaghpasand, Bardia Hajikarimloo, Roozbeh Tavanaei, Amirreza Izadi, Sam Zeraatian-Nejad and Foolad Eghbali
    Citation: Journal of Translational Medicine 2024 22:725
  12. Multimorbidity (MM) is generally defined as the presence of 2 or more chronic diseases in the same patient and seems to be frequently associated with frailty and poor quality of life. However, the complex inte...

    Authors: Francesco Piacenza, Mirko Di Rosa, Luca Soraci, Alberto Montesanto, Andrea Corsonello, Antonio Cherubini, Paolo Fabbietti, Mauro Provinciali, Rosamaria Lisa, Anna Rita Bonfigli, Elvira Filicetti, Giada Ida Greco, Lucia Muglia, Fabrizia Lattanzio, Mara Volpentesta and Leonardo Biscetti
    Citation: Journal of Translational Medicine 2024 22:669
  13. Hepatocellular carcinoma (HCC) is characterized by the complex pathogenesis, limited therapeutic methods, and poor prognosis. Endoplasmic reticulum stress (ERS) plays an important role in the development of HC...

    Authors: Zhaorui Cheng, Shuangmei Li, Shujun Yang, Huibao Long, Haidong Wu, Xuxiang Chen, Xiaoping Cheng and Tong Wang
    Citation: Journal of Translational Medicine 2024 22:658
  14. Although the inherited risk factors associated with fatty liver disease are well understood, little is known about the genetic background of metabolic dysfunction-associated steatotic liver disease (MASLD) and...

    Authors: Lushan Xiao, Yan Li, Chang Hong, Pengcheng Ma, Hongbo Zhu, Hao Cui, Xuejing Zou, Jiaren Wang, Ruining Li, Jingzhe He, Shengxing Liang, Zeyang Li, Lin Zeng and Li Liu
    Citation: Journal of Translational Medicine 2024 22:650
  15. Circadian rhythm (CR) disturbance is intricately associated with Parkinson’s disease (PD). However, the involvement of CR-related mechanisms in the pathogenesis and progression of PD remains elusive.

    Authors: Lufeng Wang, Yiwen Bao, Xiaofan Duan, Hongxia Li, Hao Ding, Fei Yu, Jie yang, Yongbo Hu and Dongya Huang
    Citation: Journal of Translational Medicine 2024 22:635
  16. An increasing proportion of lung adenocarcinoma (LUAD) occurs in patients even after they have stopped smoking. Here, we aimed to determine whether tobacco smoking induced changes across LUADs from patients wh...

    Authors: Peiyao Wang, Raymond Ng, Stephen Lam and William W. Lockwood
    Citation: Journal of Translational Medicine 2024 22:634
  17. Programmed cell death (PCD) has recently been implicated in modulating the removal of neutrophils recruited in acute myocardial infarction (AMI). Nonetheless, the clinical significance and biological mechanism...

    Authors: Yihao Zhu, Yuxi Chen and Yao Zu
    Citation: Journal of Translational Medicine 2024 22:612
  18. Accurately identifying the risk level of drug combinations is of great significance in investigating the mechanisms of combination medication and adverse reactions. Most existing methods can only predict wheth...

    Authors: Shi-Hui He, Lijun Yun and Hai-Cheng Yi
    Citation: Journal of Translational Medicine 2024 22:572
  19. No reliable clinical tools exist to predict acute kidney injury (AKI) progression. We aim to explore a scoring system for predicting the composite outcome of progression to severe AKI or death within seven day...

    Authors: Ying Su, Peng Wang, Yan Hu, Wen-jun Liu, Yi-jie Zhang, Jia-qi Chen, Yi-zhi Deng, Shuang Lin, Yue Qiu, Jia-kun Li, Chen Chen, Guo-wei Tu and Zhe Luo
    Citation: Journal of Translational Medicine 2024 22:571
  20. A former cohort study has raised concern regarding the unanticipated hazard of omeprazole in expediting osteoarthritis (OA) advancement. The precise nature of their causal evidence, however, remains undetermin...

    Authors: Siyang Cao, Yihao Wei, Yaohang Yue, Guoqing Li, Hongli Wang, Jianjing Lin, Qichang Wang, Peng Liu, Fei Yu, Ao Xiong and Hui Zeng
    Citation: Journal of Translational Medicine 2024 22:504
  21. Patients with alpha-fetoprotein (AFP)-positive hepatocellular carcinoma (HCC) have aggressive biological behavior and poor prognosis. Therefore, survival time is one of the greatest concerns for patients with ...

    Authors: Bingtian Dong, Hua Zhang, Yayang Duan, Senbang Yao, Yongjian Chen and Chaoxue Zhang
    Citation: Journal of Translational Medicine 2024 22:455
  22. Previous literature has explored the relationship between chronic atrophic gastritis (CAG) and isolated cancers within the upper gastrointestinal cancers; However, an integrative synthesis across the totality ...

    Authors: Junqiu Li, Jielu Pan, Dinghong Xiao, Nan Shen, Ruiqing Wang, Hongyv Miao, Peimin Pu, Haiyan Zhang, Xiao Yv and Lianjun Xing
    Citation: Journal of Translational Medicine 2024 22:429
  23. Ischemic heart disease is one of the leading causes of mortality worldwide, and thus calls for development of more effective therapeutic strategies. This study aimed to identify potential therapeutic targets f...

    Authors: Ziyi Sun, Zhangjun Yun, Jianguo Lin, Xiaoning Sun, Qingqing Wang, Jinlong Duan, Cheng Li, Xiaoxiao Zhang, Siyu Xu, Zeqi Wang, Xingjiang Xiong and Kuiwu Yao
    Citation: Journal of Translational Medicine 2024 22:404
  24. Most colorectal cancers originate from precancerous polyps. This study aimed to determine the prevalence of colorectal polyps with diverse pathological morphologies and to explore the risk factors for colorect...

    Authors: Xiaojuan Li, Mengting Hu, Zhangjun Wang, Mei Liu and Ying Chen
    Citation: Journal of Translational Medicine 2024 22:361
  25. Machine learning (ML) methods are increasingly becoming crucial in genome-wide association studies for identifying key genetic variants or SNPs that statistical methods might overlook. Statistical methods pred...

    Authors: Z. Alireza, M. Maleeha, M. Kaikkonen and V. Fortino
    Citation: Journal of Translational Medicine 2024 22:356
  26. Hearing loss has been shown to be a risk factor for psychiatric disorders. In addition, long-term hearing loss is associated with increased hospitalization and mortality rates; however, the increased risk and ...

    Authors: Qun-Yi Nian, Chun-An Cheng, Li-Hsiang Cheng, Yuan-Yung Lin, Chin-Hung Wang, Wu-Chien Chien, Yueng-Hsiang Chu, Cheng-Ping Shih, Chao-Yin Kuo, Hsin-Chien Chen, Jih-Chin Lee, Chi-Hsiang Chung, Wei-Chuan Shangkuan and Hung-Che Lin
    Citation: Journal of Translational Medicine 2024 22:345
  27. Melanocytes are dendritic cells localized in skin, eyes, hair follicles, ears, heart and central nervous system. They are characterized by the presence of melanosomes enriched in melanin which are responsible ...

    Authors: Kelly Coutant, Brice Magne, Karel Ferland, Aurélie Fuentes-Rodriguez, Olivier Chancy, Andrew Mitchell, Lucie Germain and Solange Landreville
    Citation: Journal of Translational Medicine 2024 22:336
  28. Lung adenocarcinoma (LUAD) is the predominant histological subtype of lung cancer and the leading cause of cancer-related mortality. Identifying effective drug targets is crucial for advancing LUAD treatment s...

    Authors: Long Zhang, Yajun Xiong, Jie Zhang, Yuying Feng and Aiguo Xu
    Citation: Journal of Translational Medicine 2024 22:330
  29. Colorectal cancer (CRC) is the third most prevalent cancer globally, and liver metastasis (CRLM) is the primary cause of death. Hence, it is essential to discover novel prognostic biomarkers and therapeutic dr...

    Authors: Xiuman Zhou, Yuzhen Qian, Chen Ling, Zhuoying He, Peishang Shi, Yanfeng Gao and Xinghua Sui
    Citation: Journal of Translational Medicine 2024 22:321
  30. A subset of Graves’ disease (GD) patients develops refractory hyperthyroidism, posing challenges in treatment decisions. The predictive value of baseline characteristics and early therapy indicators in identif...

    Authors: Xinpan Wang, Tiantian Li, Yue Li, Qiuyi Wang, Yun Cai, Zhixiao Wang, Yun Shi, Tao Yang and Xuqin Zheng
    Citation: Journal of Translational Medicine 2024 22:318
  31. Identifying individuals with mild cognitive impairment (MCI) at risk of progressing to Alzheimer’s disease (AD) provides a unique opportunity for early interventions. Therefore, accurate and long-term predicti...

    Authors: Yifan Wang, Ruitian Gao, Ting Wei, Luke Johnston, Xin Yuan, Yue Zhang and Zhangsheng Yu
    Citation: Journal of Translational Medicine 2024 22:265
  32. The term eGene has been applied to define a gene whose expression level is affected by at least one independent expression quantitative trait locus (eQTL). It is both theoretically and empirically important to...

    Authors: Shuo Zhang, Zhou Jiang and Ping Zeng
    Citation: Journal of Translational Medicine 2024 22:258
  33. Tobacco pollutants are prevalent in the environment, leading to inadvertent exposure of pregnant females. Studies of these pollutants' toxic effects on embryonic development have not fully elucidated the poten...

    Authors: Jiasheng Chen, Yuxin Lin, Deyi Gen, Wanxian Chen, Rui Han, Hao Li, Shijie Tang, Shukai Zheng and Xiaoping Zhong
    Citation: Journal of Translational Medicine 2024 22:253
  34. Spontaneous intracerebral hemorrhage (sICH) is associated with significant mortality and morbidity. Predicting the prognosis of patients with sICH remains an important issue, which significantly affects treatm...

    Authors: Zhi Geng, Chaoyi Yang, Ziye Zhao, Yibing Yan, Tao Guo, Chaofan Liu, Aimei Wu, Xingqi Wu, Ling Wei, Yanghua Tian, Panpan Hu and Kai Wang
    Citation: Journal of Translational Medicine 2024 22:236
  35. Accurate and efficient cell grouping is essential for analyzing single-cell transcriptome sequencing (scRNA-seq) data. However, the existing clustering techniques often struggle to provide timely and accurate ...

    Authors: Jun Ren, Xuejing Lyu, Jintao Guo, Xiaodong Shi, Ying Zhou and Qiyuan Li
    Citation: Journal of Translational Medicine 2024 22:233
  36. Cardiovascular diseases (CVDs) are the leading cause of death around the world. Most CVDs-related death can be prevented by the optimal management of risk factors such as unhealthy diet and physical inactivity...

    Authors: Yun Qian, Jing-Yu (Benjamin) Tan, Tao Wang, Daniel Bressington, Hong-Juan Zhou, Meng-Yuan Li and Xian-Liang Liu
    Citation: Journal of Translational Medicine 2024 22:215
  37. Clinical data mining of predictive models offers significant advantages for re-evaluating and leveraging large amounts of complex clinical real-world data and experimental comparison data for tasks such as ris...

    Authors: Huimin Qiao, Yijing Chen, Changshun Qian and You Guo
    Citation: Journal of Translational Medicine 2024 22:185
  38. Epilepsy is a common neurological disorder that affects approximately 60 million people worldwide. Characterized by unpredictable neural electrical activity abnormalities, it results in seizures with varying i...

    Authors: Yang Yang, Tianyun Luan, Zhangjun Yu, Min Zhang, Fengtian Li, Xing Chen, Fei Gao and Zhijun Zhang
    Citation: Journal of Translational Medicine 2024 22:162
  39. Telomere length has long been recognized as a valuable biomarker of aging and is inversely correlated with chronological age. Various lifestyle factors have been implicated in telomere shortening or preservati...

    Authors: Miao Chen, Zhen Wang, Hongfei Xu, Peng Teng, Weidong Li and Liang Ma
    Citation: Journal of Translational Medicine 2024 22:160
  40. This study aimed to assess the clinical application of the Artery Occlusion Image Score (AOIS), a new metric based on computed tomographic angiography (CTA) that reflects the severity of occlusive changes in t...

    Authors: Rui Xu, Shixin Peng, Yulong Qiu, Ji Zhu, Xiaodong Zhang and Li Jiang
    Citation: Journal of Translational Medicine 2024 22:152
  41. Advancements in data acquisition and computational methods are generating a large amount of heterogeneous biomedical data from diagnostic domains such as clinical imaging, pathology, and next-generation sequen...

    Authors: Valentina Brancato, Giuseppina Esposito, Luigi Coppola, Carlo Cavaliere, Peppino Mirabelli, Camilla Scapicchio, Rita Borgheresi, Emanuele Neri, Marco Salvatore and Marco Aiello
    Citation: Journal of Translational Medicine 2024 22:136
  42. Fertility preservation treatment is increasingly essential for patients with apical endometrial hyperplasia (AEH) and early endometrial cancer (EEC) worldwide. Complete regression (CR) is the main endpoint of ...

    Authors: Xingchen Li, Yiqin Wang, Jiaqi Wang, Yuan Fan and Jianliu Wang
    Citation: Journal of Translational Medicine 2024 22:127
  43. Multi-omics approaches have been successfully applied to investigate pregnancy and health outcomes at a molecular and genetic level in several studies. As omics technologies advance, research areas are open to...

    Authors: Ali Rahnavard, Ranojoy Chatterjee, Hui Wen, Clark Gaylord, Sabina Mugusi, Kevin C. Klatt and Emily R. Smith
    Citation: Journal of Translational Medicine 2024 22:106
  44. Several large cohort studies in cardiovascular disease (CVD) patients have shown an increased incidence of cancer. Previous studies in a myocardial infarction (MI) mouse model reported increased colon, breast,...

    Authors: Tanawat Attachaipanich, Siriporn C. Chattipakorn and Nipon Chattipakorn
    Citation: Journal of Translational Medicine 2024 22:105
  45. Allergic diseases (ADs) such as asthma are presumed risk factors for COVID-19 infection. However, recent observational studies suggest that the assumed correlation contradicts each other. We therefore systemat...

    Authors: Xiao-tong Chen, Shuai Zhi, Xin-yu Han, Jian-wei Jiang, Guang-ming Liu and Shi-tao Rao
    Citation: Journal of Translational Medicine 2024 22:94
  46. The long-term impact of COVID-19-associated public health interventions on zoonotic and vector-borne infectious diseases (ZVBs) remains uncertain. This study sought to examine the changes in ZVBs in China duri...

    Authors: Yongbin Wang, Siyu Qing, Xianxiang Lan, Lun Li, Peiping Zhou, Yue Xi, Ziyue Liang, Chenguang Zhang and Chunjie Xu
    Citation: Journal of Translational Medicine 2024 22:81

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