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Computational modelling and Epidemiology

Section edited by Michael N. Liebman and Sabrina Molinaro

This section aims to allow rapid communication of methods and results that utilize computational modeling and epidemiologic approaches in translational medicine. The focus will be on population-based studies that extend towards more molecular level analysis. 

Submission of studies involving methods development is encouraged where actual application and results can be shown in the healthcare and life sciences domains. Among the approaches highlighted in this section are data-mining for health impact, data modeling, health record system design, applications of epidemiologic analysis, public policy evaluation, hypothesis evaluation and testing, risk assessment in healthcare and life sciences. These articles will describe the perspective on translational medicine where the approach and results reflect the computational modeling and epidemiologic aspects of this emerging area of research.

Featured articles

Impact of lockdown on Covid-19 case fatality rate and viral mutations spread in 7 countries in Europe and North America

Research | Maria Pachetti et al

Analysis of SARS-CoV-2 RNA-dependent RNA polymerase as a potential therapeutic drug target using a computational approach

Research | Syed Ovais Aftab et al


The effects of statins on dental and oral health: a review of preclinical and clinical studies

Review | Shabnam Tahamtan et al

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  1. Asbestos lung content is regarded as the most reliable tool for causal attribution of malignant mesothelioma (MM) to previous asbestos exposures. However, there is a lack of studies on asbestos burden in lungs...

    Authors: S. D. Visonà, B. Bertoglio, C. Favaron, S. Capella, E. Belluso, C. Colosio, S. Villani, T. Ivic-Pavlicic and E. Taioli
    Citation: Journal of Translational Medicine 2023 21:875
  2. The spread of COVID-19 has brought challenges to health, social and economic systems around the world. With little to no prior immunity in the global population, transmission has been driven primarily by human...

    Authors: Jamie D. Mullineaux, Baptiste Leurent and Takoua Jendoubi
    Citation: Journal of Translational Medicine 2023 21:848
  3. Cardiovascular disease (CVD) is a major complication in type 1 diabetes mellitus (T1D) patients. Previous studies have suggested that statins may be helpful for prevention of CVD in T1D, but there are limited ...

    Authors: Joonsang Yoo, Jimin Jeon, Minyoul Baek, Sun Ok Song and Jinkwon Kim
    Citation: Journal of Translational Medicine 2023 21:806
  4. The 70-gene signature (70-GS, MammaPrint) test has been recommended by the main guidelines to evaluate prognosis and chemotherapy benefit of hormonal receptor positive human epidermal receptor 2 negative (HR +...

    Authors: Bo Pan, Ying Xu, Ru Yao, Xi Cao, Xingtong Zhou, Zhixin Hao, Yanna Zhang, Changjun Wang, Songjie Shen, Yanwen Luo, Qingli Zhu, Xinyu Ren, Lingyan Kong, Yidong Zhou and Qiang Sun
    Citation: Journal of Translational Medicine 2023 21:798
  5. Although chronic inflammation, oxidative stress, airway remodeling, and protease-antiprotease imbalance have been implicated in chronic obstructive pulmonary disease (COPD), the exact pathogenesis is still obs...

    Authors: Beibei Li, Jiajun Zhang, Hui Dong, Xueyan Feng, Liang Yu, Jinyuan Zhu and Jin Zhang
    Citation: Journal of Translational Medicine 2023 21:790
  6. Early prevention of Alzheimer’s disease (AD) is a feasible way to delay AD onset and progression. Information on AD prediction at the individual patient level will be useful in AD prevention. In this study, we...

    Authors: Xiao-He Hou, John Suckling, Xue-Ning Shen, Yong Liu, Chuan-Tao Zuo, Yu-Yuan Huang, Hong-Qi Li, Hui-Fu Wang, Chen-Chen Tan, Mei Cui, Qiang Dong, Lan Tan and Jin-Tai Yu
    Citation: Journal of Translational Medicine 2023 21:768
  7. The unfolding protein response is a critical biological process implicated in a variety of physiological functions and disease states across eukaryotes. Despite its significance, the role and underlying mechan...

    Authors: Haiyang Yu, Xiaoyu Ji and Yang Ouyang
    Citation: Journal of Translational Medicine 2023 21:759
  8. Patients with heart failure with reduced ejection fraction (HFrEF) and central sleep apnea (CSA) are at a very high risk of fatal outcomes.

    Authors: David de Gonzalo-Calvo, Pablo Martinez-Camblor, Thalia Belmonte, Ferran Barbé, Kevin Duarte, Martin R. Cowie, Christiane E. Angermann, Andrea Korte, Isabelle Riedel, Josephine Labus, Wolfgang Koenig, Faiez Zannad, Thomas Thum and Christian Bär
    Citation: Journal of Translational Medicine 2023 21:742
  9. This paper addresses the crucial task of identifying DNA/RNA binding sites, which has implications in drug/vaccine design, protein engineering, and cancer research. Existing methods utilize complex neural netw...

    Authors: Saeedeh Akbari Rokn Abadi, SeyedehFatemeh Tabatabaei and Somayyeh Koohi
    Citation: Journal of Translational Medicine 2023 21:727
  10. With the development and popularization of low-dose chest CT technology, the diagnosis and survival rates of patients with early lung cancer (LC) have significantly improved. The occurrence of colorectal cance...

    Authors: Zhihan Xiao, Zichen Wang, Tongyu Zhang, Yi Liu and Mingxuan Si
    Citation: Journal of Translational Medicine 2023 21:722
  11. Epidemiological studies demonstrated that multiple amino acids (AAs) were associated with cardiovascular diseases (CVDs), but whether these associations were causal remains unclear. This study aims to investig...

    Authors: Song Hu, Zhennan Lin, Meng-Jin Hu, Jiang-Shan Tan, Ting-Ting Guo, Xin Huang and Lu Hua
    Citation: Journal of Translational Medicine 2023 21:699
  12. Laryngopharyngeal cancer (LPC) includes laryngeal and hypopharyngeal cancer, whose early diagnosis can significantly improve the prognosis and quality of life of patients. Pathological biopsy of suspicious can...

    Authors: Yun Li, Wenxin Gu, Huijun Yue, Guoqing Lei, Wenbin Guo, Yihui Wen, Haocheng Tang, Xin Luo, Wenjuan Tu, Jin Ye, Ruomei Hong, Qian Cai, Qingyu Gu, Tianrun Liu, Beiping Miao, Ruxin Wang…
    Citation: Journal of Translational Medicine 2023 21:698
  13. Two versions of Framingham’s 10-year risk score are defined for cardiovascular diseases, namely laboratory-based and office-based models. The former is mainly employed in high-income countries, but unfortunate...

    Authors: Azizallah Dehghan, Sajjad Ahmadnia Motlagh, Rozhan Khezri, Fatemeh Rezaei and Dagfinn Aune
    Citation: Journal of Translational Medicine 2023 21:687
  14. Rapid identification of high-risk polytrauma patients is crucial for early intervention and improved outcomes. This study aimed to develop and validate machine learning models for predicting 72 h mortality in ...

    Authors: Wen He, Xianghong Fu and Song Chen
    Citation: Journal of Translational Medicine 2023 21:664
  15. Intracranial aneurysms (IAs) pose a significant and intricate challenge. Elucidating the interplay between DNA methylation and IA pathogenesis is paramount to identify potential biomarkers and therapeutic inte...

    Authors: Aierpati Maimaiti, Mirzat Turhon, Aimitaji Abulaiti, Yilidanna Dilixiati, Fujunhui Zhang, Aximujiang Axieer, Kaheerman Kadeer, Yisen Zhang, Aisha Maimaitili and Xinjian Yang
    Citation: Journal of Translational Medicine 2023 21:660
  16. The interest in targeted cancer therapies has been growing rapidly. While numerous cancer biomarkers and targeted treatment strategies have been developed and employed, there are still significant limitations ...

    Authors: Feihong Ren, Qiubai Jin, Tongtong Liu, Xuelei Ren and Yongli Zhan
    Citation: Journal of Translational Medicine 2023 21:646
  17. Biological ageing is tightly linked to cardiovascular disease (CVD). We aimed to investigate the relationship between Life’s Essential 8 (LE8), a currently updated measure of cardiovascular health (CVH), and b...

    Authors: Ronghuai Zhang, Min Wu, Wei Zhang, Xuna Liu, Jie Pu, Tao Wei, Zhanfang Zhu, Zhiguo Tang, Na Wei, Bo Liu, Qianwei Cui, Junkui Wang, Fuqiang Liu and Ying Lv
    Citation: Journal of Translational Medicine 2023 21:622
  18. A significant proportion of septic patients with acute lung injury (ALI) are recognized late due to the absence of an efficient diagnostic test, leading to the postponed treatments and consequently higher mort...

    Authors: Yongxin Zheng, Jinping Wang, Zhaoyi Ling, Jiamei Zhang, Yuan Zeng, Ke Wang, Yu Zhang, Lingbo Nong, Ling Sang, Yonghao Xu, Xiaoqing Liu, Yimin Li and Yongbo Huang
    Citation: Journal of Translational Medicine 2023 21:620
  19. Assisted reproductive technologies (ART) have increased the incidence of multiple births, which can have a negative impact on maternal and offspring health. The study aimed to investigate the association betwe...

    Authors: Yi Jiang, Yuanyuan Du, Rui Su, Xuan Zhou, Lijie Wei, Jingyi Zhang, Shenglan Zhu, Huiting Zhang, Chenyun Fang, Yuting Chen, Peng Gao, Liangnan Zhang, Shaoshuai Wang, Jun Yu, Mengzhou He, Wencheng Ding…
    Citation: Journal of Translational Medicine 2023 21:608
  20. The influence of the historical cardiovascular risk status on future risk of atherosclerotic cardiovascular disease (ASCVD) is poorly understood. We aimed to investigate the association between 5-year changes ...

    Authors: Jiayi Yi, Lili Wang, Xinli Guo and Xiangpeng Ren
    Citation: Journal of Translational Medicine 2023 21:589
  21. Currently, women around the world are still suffering from various female common diseases with the high incidence, such as ovarian cancer, uterine fibroids and preeclampsia (PE), and some diseases are even wit...

    Authors: Qiang Xu, Mukun Yao and Chao Tang
    Citation: Journal of Translational Medicine 2023 21:583
  22. Alzheimer’s disease (AD) and cancer are common age-related diseases, and epidemiological evidence suggests an inverse relationship between them. However, investigating the potential mechanism underlying their ...

    Authors: Zehua Dong, Mengli Xu, Xu Sun and Xiaosheng Wang
    Citation: Journal of Translational Medicine 2023 21:527
  23. In patients undergoing percutaneous coronary intervention (PCI), contrast-induced acute kidney injury (CIAKI) is a frequent complication, especially in diabetics, and is connected with severe mortality and mor...

    Authors: Mengqing Ma, Xin Wan, Yuyang Chen, Zhichao Lu, Danning Guo, Huiping Kong, Binbin Pan, Hao Zhang, Dawei Chen, Dongxu Xu, Dong Sun, Hong Lang, Changgao Zhou, Tao Li and Changchun Cao
    Citation: Journal of Translational Medicine 2023 21:517
  24. Computational models are increasingly used in high-impact decision making in science, engineering, and medicine. The National Aeronautics and Space Administration (NASA) uses computational models to perform co...

    Authors: Lillian T. Tatka, Lucian P. Smith, Joseph L. Hellerstein and Herbert M. Sauro
    Citation: Journal of Translational Medicine 2023 21:501
  25. The nuclear factor kappa B (NFκB) regulatory pathways downstream of tumor necrosis factor (TNF) play a critical role in carcinogenesis. However, the widespread influence of NFκB in cells can result in off-targ...

    Authors: Yin-Yuan Su, Yu-Ling Liu, Hsuan-Cheng Huang and Chen-Ching Lin
    Citation: Journal of Translational Medicine 2023 21:485
  26. Blood biomarkers for multiple pathways, such as inflammatory response, lipid metabolism, and hormonal regulation, have been suggested to influence the risk of mortality. However, few studies have systematicall...

    Authors: Jing Yang, Jiayi Lu, Junyan Miao, Jiacong Li, Meng Zhu, Juncheng Dai, Hongxia Ma, Guangfu Jin and Dong Hang
    Citation: Journal of Translational Medicine 2023 21:471
  27. The protective effect of a higher ideal cardiovascular health (CVH) score on cardiovascular diseases (CVDs) and mortality is well recognized. However, little is known regarding the length of favorable CVH stat...

    Authors: Qiuyue Tian, Shuohua Chen, Xiaoni Meng, Haotian Wang, Cancan Li, Deqiang Zheng, Lijuan Wu, Aitian Wang, Shouling Wu and Youxin Wang
    Citation: Journal of Translational Medicine 2023 21:469
  28. The prevalence of hyperuricemia, gout, and heart failure (HF) is on the rise, and these conditions often share similar risk factors. The present study aimed to evaluate the relationship among hyperuricemia, go...

    Authors: Yingdong Han, Yu Cao, Xinxin Han, Hong Di, Yue Yin, Juan Wu, Yun Zhang and Xuejun Zeng
    Citation: Journal of Translational Medicine 2023 21:463
  29. Non-alcoholic fatty liver disease (NAFLD) shares common risk factors with cardiovascular diseases. Effects of longitudinal trends in non-high-density lipoprotein (non-HDL) cholesterol on NAFLD development are ...

    Authors: Jun-Hyuk Lee, Jiyeon Kim, Jung Oh Kim and Yu-Jin Kwon
    Citation: Journal of Translational Medicine 2023 21:435
  30. Colonoscopy is a useful as a cancer screening test. However, in countries with limited medical resources, there are restrictions on the widespread use of endoscopy. Non-invasive screening methods to determine ...

    Authors: Kohjiro Tokutake, Aaron Morelos-Gomez, Ken-ichi Hoshi, Michio Katouda, Syogo Tejima and Morinobu Endo
    Citation: Journal of Translational Medicine 2023 21:431
  31. Acute kidney injury (AKI) is a common complication in critically ill patients with sepsis and is often associated with a poor prognosis. We aimed to construct and validate an interpretable prognostic predictio...

    Authors: Zhiyan Fan, Jiamei Jiang, Chen Xiao, Youlei Chen, Quan Xia, Juan Wang, Mengjuan Fang, Zesheng Wu and Fanghui Chen
    Citation: Journal of Translational Medicine 2023 21:406
  32. Breast cancer brain metastases (BCBM) are the most fatal, with limited survival in all breast cancer distant metastases. These patients are deemed to be incurable. Thus, survival time is their foremost concern...

    Authors: Chaofan Li, Mengjie Liu, Yinbin Zhang, Yusheng Wang, Jia Li, Shiyu Sun, Xuanyu Liu, Huizi Wu, Cong Feng, Peizhuo Yao, Yiwei Jia, Yu Zhang, Xinyu Wei, Fei Wu, Chong Du, Xixi Zhao…
    Citation: Journal of Translational Medicine 2023 21:404
  33. Autism spectrum disorder (ASD) is a neurodevelopmental disorder that is difficult to diagnose. Inflammatory bowel disease (IBD) is a common chronic digestive disease. Previous studies have shown a potential co...

    Authors: Jinyi Zhu, Haoran Meng, Li Zhang and Yan Li
    Citation: Journal of Translational Medicine 2023 21:372
  34. Novel human epidermal growth factor receptor 2 (HER2)-directed antibody–drug conjugates prompt the identification of the HER2-low subtype. However, the biological significance of HER2-low expression in breast ...

    Authors: Juan Jin, Bin Li, Jianing Cao, Ting Li, Jian Zhang, Jun Cao, Mingchuan Zhao, Leiping Wang, Biyun Wang, Zhonghua Tao and Xichun Hu
    Citation: Journal of Translational Medicine 2023 21:360
  35. Chronic kidney disease (CKD) is one of the most significant cardiovascular risk factors, playing vital roles in various cardiovascular diseases such as calcific aortic valve disease (CAVD). We aim to explore t...

    Authors: Enyi Zhu, Xiaorong Shu, Zi Xu, Yanren Peng, Yunxiu Xiang, Yu Liu, Hui Guan, Ming Zhong, Jinhong Li, Li-Zhen Zhang, Ruqiong Nie and Zhihua Zheng
    Citation: Journal of Translational Medicine 2023 21:359
  36. Osteoarthritis (OA) is one of the most prevalent musculoskeletal diseases and is the leading cause of pain and disability in the aged population. However, the underlying biological mechanism has not been fully...

    Authors: Yifei Gu, Qianmei Jin, Jinquan Hu, Xinwei Wang, Wenchao Yu, Zhanchao Wang, Chen Wang, Yang Liu, Yu Chen and Wen Yuan
    Citation: Journal of Translational Medicine 2023 21:357
  37. Carotid atherosclerosis (CAS), an important factor in the development of stroke, is a major public health concern. The aim of this study was to establish and validate machine learning (ML) models for early scr...

    Authors: Ke Yun, Tao He, Shi Zhen, Meihui Quan, Xiaotao Yang, Dongliang Man, Shuang Zhang, Wei Wang and Xiaoxu Han
    Citation: Journal of Translational Medicine 2023 21:353
  38. The current ageing trend of the world population has, in part, accounted for Alzheimer disease (AD) being a public health issue in recent times. Although some progress has been made in clarifying AD-related pa...

    Authors: Benson O. A. Botchway, Xuehong Liu, Yu Zhou and Marong Fang
    Citation: Journal of Translational Medicine 2023 21:351
  39. Clear cell renal cell carcinoma (ccRCC) is a highly invasive and metastatic subtype of kidney malignancy and is correlated with metabolic reprogramming for adaptation to the tumor microenvironment comprising i...

    Authors: Hansen Lin, Liangmin Fu, Pengju Li, Jiangquan Zhu, Quanhui Xu, Yinghan Wang, Mukhtar Adan Mumin, Xinwei Zhou, Yuhang Chen, Guannan Shu, Gaosheng Yao, Minyu Chen, Jun Lu, Lizhen Zhang, YuJun Liu, Yiqi Zhao…
    Citation: Journal of Translational Medicine 2023 21:343
  40. The Swedish Childhood Tumor Biobank (BTB) is a nonprofit national infrastructure for collecting tissue samples and genomic data from pediatric patients diagnosed with central nervous system (CNS) and other sol...

    Authors: Teresita Díaz de Ståhl, Alia Shamikh, Markus Mayrhofer, Szilvester Juhos, Elisa Basmaci, Gabriela Prochazka, Maxime Garcia, Praveen Raj Somarajan, Katarzyna Zielinska-Chomej, Christopher Illies, Ingrid Øra, Peter Siesjö, Per-Erik Sandström, Jakob Stenman, Magnus Sabel, Bengt Gustavsson…
    Citation: Journal of Translational Medicine 2023 21:342
  41. It is known that measuring the triglyceride glucose (TyG) index and TyG-related parameters [triglyceride glucose-body mass index (TyG-BMI), triglyceride glucose-waist circumference (TyG-WC), and triglyceride g...

    Authors: Maobin Kuang, Ruijuan Yang, Xin Huang, Chao Wang, Guotai Sheng, Guobo Xie and Yang Zou
    Citation: Journal of Translational Medicine 2023 21:299
  42. The growing epidemic of the inflammation-related metabolic disease, type 2 diabetes mellitus, presents a challenge to improve our understanding of potential mechanisms or biomarkers to prevent or better contro...

    Authors: Nicole Noren Hooten, Nicolle A. Mode, Edward Kowalik, Victor Omoniyi, Alan B. Zonderman, Ngozi Ezike, Mark J. DiNubile, Susan L. Levinson and Michele K. Evans
    Citation: Journal of Translational Medicine 2023 21:190
  43. Circadian rhythm regulates complex physiological activities in organisms. A strong link between circadian dysfunction and cancer has been identified. However, the factors of dysregulation and functional signif...

    Authors: Yuwei Liu, Shuang Guo, Yue Sun, Caiyu Zhang, Jing Gan, Shangwei Ning and Junwei Wang
    Citation: Journal of Translational Medicine 2023 21:185
  44. Gastric cancer (GC) is a major cancer burden throughout the world with a high mortality rate. The performance of current predictive and prognostic factors is still limited. Integrated analysis is required for ...

    Authors: Wenying Yan, Yuqi Chen, Guang Hu, Tongguo Shi, Xingyi Liu, Juntao Li, Linqing Sun, Fuliang Qian and Weichang Chen
    Citation: Journal of Translational Medicine 2023 21:163
  45. The United Nations recently made a call to address the challenges of an estimated 300 million persons worldwide living with a rare disease through the collection, analysis, and dissemination of disaggregated d...

    Authors: William Z. Kariampuzha, Gioconda Alyea, Sue Qu, Jaleal Sanjak, Ewy Mathé, Eric Sid, Haley Chatelaine, Arjun Yadaw, Yanji Xu and Qian Zhu
    Citation: Journal of Translational Medicine 2023 21:157

    The Correction to this article has been published in Journal of Translational Medicine 2023 21:291

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