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Computational modelling and Epidemiology

Section edited by Michael N. Liebman and Sabrina Molinaro

This section aims to allow rapid communication of methods and results that utilize computational modeling and epidemiologic approaches in translational medicine. The focus will be on population-based studies that extend towards more molecular level analysis. 

Submission of studies involving methods development is encouraged where actual application and results can be shown in the healthcare and life sciences domains. Among the approaches highlighted in this section are data-mining for health impact, data modeling, health record system design, applications of epidemiologic analysis, public policy evaluation, hypothesis evaluation and testing, risk assessment in healthcare and life sciences. These articles will describe the perspective on translational medicine where the approach and results reflect the computational modeling and epidemiologic aspects of this emerging area of research.

Featured articles

Impact of lockdown on Covid-19 case fatality rate and viral mutations spread in 7 countries in Europe and North America

Research | Maria Pachetti et al

Analysis of SARS-CoV-2 RNA-dependent RNA polymerase as a potential therapeutic drug target using a computational approach

Research | Syed Ovais Aftab et al


The effects of statins on dental and oral health: a review of preclinical and clinical studies

Review | Shabnam Tahamtan et al

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  1. Hepatocellular carcinoma (HCC) is characterized by the complex pathogenesis, limited therapeutic methods, and poor prognosis. Endoplasmic reticulum stress (ERS) plays an important role in the development of HC...

    Authors: Zhaorui Cheng, Shuangmei Li, Shujun Yang, Huibao Long, Haidong Wu, Xuxiang Chen, Xiaoping Cheng and Tong Wang
    Citation: Journal of Translational Medicine 2024 22:658
  2. Although the inherited risk factors associated with fatty liver disease are well understood, little is known about the genetic background of metabolic dysfunction-associated steatotic liver disease (MASLD) and...

    Authors: Lushan Xiao, Yan Li, Chang Hong, Pengcheng Ma, Hongbo Zhu, Hao Cui, Xuejing Zou, Jiaren Wang, Ruining Li, Jingzhe He, Shengxing Liang, Zeyang Li, Lin Zeng and Li Liu
    Citation: Journal of Translational Medicine 2024 22:650
  3. Circadian rhythm (CR) disturbance is intricately associated with Parkinson’s disease (PD). However, the involvement of CR-related mechanisms in the pathogenesis and progression of PD remains elusive.

    Authors: Lufeng Wang, Yiwen Bao, Xiaofan Duan, Hongxia Li, Hao Ding, Fei Yu, Jie yang, Yongbo Hu and Dongya Huang
    Citation: Journal of Translational Medicine 2024 22:635
  4. An increasing proportion of lung adenocarcinoma (LUAD) occurs in patients even after they have stopped smoking. Here, we aimed to determine whether tobacco smoking induced changes across LUADs from patients wh...

    Authors: Peiyao Wang, Raymond Ng, Stephen Lam and William W. Lockwood
    Citation: Journal of Translational Medicine 2024 22:634
  5. Programmed cell death (PCD) has recently been implicated in modulating the removal of neutrophils recruited in acute myocardial infarction (AMI). Nonetheless, the clinical significance and biological mechanism...

    Authors: Yihao Zhu, Yuxi Chen and Yao Zu
    Citation: Journal of Translational Medicine 2024 22:612
  6. Accurately identifying the risk level of drug combinations is of great significance in investigating the mechanisms of combination medication and adverse reactions. Most existing methods can only predict wheth...

    Authors: Shi-Hui He, Lijun Yun and Hai-Cheng Yi
    Citation: Journal of Translational Medicine 2024 22:572
  7. No reliable clinical tools exist to predict acute kidney injury (AKI) progression. We aim to explore a scoring system for predicting the composite outcome of progression to severe AKI or death within seven day...

    Authors: Ying Su, Peng Wang, Yan Hu, Wen-jun Liu, Yi-jie Zhang, Jia-qi Chen, Yi-zhi Deng, Shuang Lin, Yue Qiu, Jia-kun Li, Chen Chen, Guo-wei Tu and Zhe Luo
    Citation: Journal of Translational Medicine 2024 22:571
  8. A former cohort study has raised concern regarding the unanticipated hazard of omeprazole in expediting osteoarthritis (OA) advancement. The precise nature of their causal evidence, however, remains undetermin...

    Authors: Siyang Cao, Yihao Wei, Yaohang Yue, Guoqing Li, Hongli Wang, Jianjing Lin, Qichang Wang, Peng Liu, Fei Yu, Ao Xiong and Hui Zeng
    Citation: Journal of Translational Medicine 2024 22:504
  9. Patients with alpha-fetoprotein (AFP)-positive hepatocellular carcinoma (HCC) have aggressive biological behavior and poor prognosis. Therefore, survival time is one of the greatest concerns for patients with ...

    Authors: Bingtian Dong, Hua Zhang, Yayang Duan, Senbang Yao, Yongjian Chen and Chaoxue Zhang
    Citation: Journal of Translational Medicine 2024 22:455
  10. Previous literature has explored the relationship between chronic atrophic gastritis (CAG) and isolated cancers within the upper gastrointestinal cancers; However, an integrative synthesis across the totality ...

    Authors: Junqiu Li, Jielu Pan, Dinghong Xiao, Nan Shen, Ruiqing Wang, Hongyv Miao, Peimin Pu, Haiyan Zhang, Xiao Yv and Lianjun Xing
    Citation: Journal of Translational Medicine 2024 22:429
  11. Ischemic heart disease is one of the leading causes of mortality worldwide, and thus calls for development of more effective therapeutic strategies. This study aimed to identify potential therapeutic targets f...

    Authors: Ziyi Sun, Zhangjun Yun, Jianguo Lin, Xiaoning Sun, Qingqing Wang, Jinlong Duan, Cheng Li, Xiaoxiao Zhang, Siyu Xu, Zeqi Wang, Xingjiang Xiong and Kuiwu Yao
    Citation: Journal of Translational Medicine 2024 22:404
  12. Most colorectal cancers originate from precancerous polyps. This study aimed to determine the prevalence of colorectal polyps with diverse pathological morphologies and to explore the risk factors for colorect...

    Authors: Xiaojuan Li, Mengting Hu, Zhangjun Wang, Mei Liu and Ying Chen
    Citation: Journal of Translational Medicine 2024 22:361
  13. Machine learning (ML) methods are increasingly becoming crucial in genome-wide association studies for identifying key genetic variants or SNPs that statistical methods might overlook. Statistical methods pred...

    Authors: Z. Alireza, M. Maleeha, M. Kaikkonen and V. Fortino
    Citation: Journal of Translational Medicine 2024 22:356
  14. Hearing loss has been shown to be a risk factor for psychiatric disorders. In addition, long-term hearing loss is associated with increased hospitalization and mortality rates; however, the increased risk and ...

    Authors: Qun-Yi Nian, Chun-An Cheng, Li-Hsiang Cheng, Yuan-Yung Lin, Chin-Hung Wang, Wu-Chien Chien, Yueng-Hsiang Chu, Cheng-Ping Shih, Chao-Yin Kuo, Hsin-Chien Chen, Jih-Chin Lee, Chi-Hsiang Chung, Wei-Chuan Shangkuan and Hung-Che Lin
    Citation: Journal of Translational Medicine 2024 22:345
  15. Melanocytes are dendritic cells localized in skin, eyes, hair follicles, ears, heart and central nervous system. They are characterized by the presence of melanosomes enriched in melanin which are responsible ...

    Authors: Kelly Coutant, Brice Magne, Karel Ferland, Aurélie Fuentes-Rodriguez, Olivier Chancy, Andrew Mitchell, Lucie Germain and Solange Landreville
    Citation: Journal of Translational Medicine 2024 22:336
  16. Lung adenocarcinoma (LUAD) is the predominant histological subtype of lung cancer and the leading cause of cancer-related mortality. Identifying effective drug targets is crucial for advancing LUAD treatment s...

    Authors: Long Zhang, Yajun Xiong, Jie Zhang, Yuying Feng and Aiguo Xu
    Citation: Journal of Translational Medicine 2024 22:330
  17. Colorectal cancer (CRC) is the third most prevalent cancer globally, and liver metastasis (CRLM) is the primary cause of death. Hence, it is essential to discover novel prognostic biomarkers and therapeutic dr...

    Authors: Xiuman Zhou, Yuzhen Qian, Chen Ling, Zhuoying He, Peishang Shi, Yanfeng Gao and Xinghua Sui
    Citation: Journal of Translational Medicine 2024 22:321
  18. A subset of Graves’ disease (GD) patients develops refractory hyperthyroidism, posing challenges in treatment decisions. The predictive value of baseline characteristics and early therapy indicators in identif...

    Authors: Xinpan Wang, Tiantian Li, Yue Li, Qiuyi Wang, Yun Cai, Zhixiao Wang, Yun Shi, Tao Yang and Xuqin Zheng
    Citation: Journal of Translational Medicine 2024 22:318
  19. Identifying individuals with mild cognitive impairment (MCI) at risk of progressing to Alzheimer’s disease (AD) provides a unique opportunity for early interventions. Therefore, accurate and long-term predicti...

    Authors: Yifan Wang, Ruitian Gao, Ting Wei, Luke Johnston, Xin Yuan, Yue Zhang and Zhangsheng Yu
    Citation: Journal of Translational Medicine 2024 22:265
  20. The term eGene has been applied to define a gene whose expression level is affected by at least one independent expression quantitative trait locus (eQTL). It is both theoretically and empirically important to...

    Authors: Shuo Zhang, Zhou Jiang and Ping Zeng
    Citation: Journal of Translational Medicine 2024 22:258
  21. Tobacco pollutants are prevalent in the environment, leading to inadvertent exposure of pregnant females. Studies of these pollutants' toxic effects on embryonic development have not fully elucidated the poten...

    Authors: Jiasheng Chen, Yuxin Lin, Deyi Gen, Wanxian Chen, Rui Han, Hao Li, Shijie Tang, Shukai Zheng and Xiaoping Zhong
    Citation: Journal of Translational Medicine 2024 22:253
  22. Spontaneous intracerebral hemorrhage (sICH) is associated with significant mortality and morbidity. Predicting the prognosis of patients with sICH remains an important issue, which significantly affects treatm...

    Authors: Zhi Geng, Chaoyi Yang, Ziye Zhao, Yibing Yan, Tao Guo, Chaofan Liu, Aimei Wu, Xingqi Wu, Ling Wei, Yanghua Tian, Panpan Hu and Kai Wang
    Citation: Journal of Translational Medicine 2024 22:236
  23. Accurate and efficient cell grouping is essential for analyzing single-cell transcriptome sequencing (scRNA-seq) data. However, the existing clustering techniques often struggle to provide timely and accurate ...

    Authors: Jun Ren, Xuejing Lyu, Jintao Guo, Xiaodong Shi, Ying Zhou and Qiyuan Li
    Citation: Journal of Translational Medicine 2024 22:233
  24. Cardiovascular diseases (CVDs) are the leading cause of death around the world. Most CVDs-related death can be prevented by the optimal management of risk factors such as unhealthy diet and physical inactivity...

    Authors: Yun Qian, Jing-Yu (Benjamin) Tan, Tao Wang, Daniel Bressington, Hong-Juan Zhou, Meng-Yuan Li and Xian-Liang Liu
    Citation: Journal of Translational Medicine 2024 22:215
  25. Clinical data mining of predictive models offers significant advantages for re-evaluating and leveraging large amounts of complex clinical real-world data and experimental comparison data for tasks such as ris...

    Authors: Huimin Qiao, Yijing Chen, Changshun Qian and You Guo
    Citation: Journal of Translational Medicine 2024 22:185
  26. Epilepsy is a common neurological disorder that affects approximately 60 million people worldwide. Characterized by unpredictable neural electrical activity abnormalities, it results in seizures with varying i...

    Authors: Yang Yang, Tianyun Luan, Zhangjun Yu, Min Zhang, Fengtian Li, Xing Chen, Fei Gao and Zhijun Zhang
    Citation: Journal of Translational Medicine 2024 22:162
  27. Telomere length has long been recognized as a valuable biomarker of aging and is inversely correlated with chronological age. Various lifestyle factors have been implicated in telomere shortening or preservati...

    Authors: Miao Chen, Zhen Wang, Hongfei Xu, Peng Teng, Weidong Li and Liang Ma
    Citation: Journal of Translational Medicine 2024 22:160
  28. This study aimed to assess the clinical application of the Artery Occlusion Image Score (AOIS), a new metric based on computed tomographic angiography (CTA) that reflects the severity of occlusive changes in t...

    Authors: Rui Xu, Shixin Peng, Yulong Qiu, Ji Zhu, Xiaodong Zhang and Li Jiang
    Citation: Journal of Translational Medicine 2024 22:152
  29. Advancements in data acquisition and computational methods are generating a large amount of heterogeneous biomedical data from diagnostic domains such as clinical imaging, pathology, and next-generation sequen...

    Authors: Valentina Brancato, Giuseppina Esposito, Luigi Coppola, Carlo Cavaliere, Peppino Mirabelli, Camilla Scapicchio, Rita Borgheresi, Emanuele Neri, Marco Salvatore and Marco Aiello
    Citation: Journal of Translational Medicine 2024 22:136
  30. Fertility preservation treatment is increasingly essential for patients with apical endometrial hyperplasia (AEH) and early endometrial cancer (EEC) worldwide. Complete regression (CR) is the main endpoint of ...

    Authors: Xingchen Li, Yiqin Wang, Jiaqi Wang, Yuan Fan and Jianliu Wang
    Citation: Journal of Translational Medicine 2024 22:127
  31. Multi-omics approaches have been successfully applied to investigate pregnancy and health outcomes at a molecular and genetic level in several studies. As omics technologies advance, research areas are open to...

    Authors: Ali Rahnavard, Ranojoy Chatterjee, Hui Wen, Clark Gaylord, Sabina Mugusi, Kevin C. Klatt and Emily R. Smith
    Citation: Journal of Translational Medicine 2024 22:106
  32. Several large cohort studies in cardiovascular disease (CVD) patients have shown an increased incidence of cancer. Previous studies in a myocardial infarction (MI) mouse model reported increased colon, breast,...

    Authors: Tanawat Attachaipanich, Siriporn C. Chattipakorn and Nipon Chattipakorn
    Citation: Journal of Translational Medicine 2024 22:105
  33. Allergic diseases (ADs) such as asthma are presumed risk factors for COVID-19 infection. However, recent observational studies suggest that the assumed correlation contradicts each other. We therefore systemat...

    Authors: Xiao-tong Chen, Shuai Zhi, Xin-yu Han, Jian-wei Jiang, Guang-ming Liu and Shi-tao Rao
    Citation: Journal of Translational Medicine 2024 22:94
  34. The long-term impact of COVID-19-associated public health interventions on zoonotic and vector-borne infectious diseases (ZVBs) remains uncertain. This study sought to examine the changes in ZVBs in China duri...

    Authors: Yongbin Wang, Siyu Qing, Xianxiang Lan, Lun Li, Peiping Zhou, Yue Xi, Ziyue Liang, Chenguang Zhang and Chunjie Xu
    Citation: Journal of Translational Medicine 2024 22:81
  35. With the increase of aging population and prevalence of obesity, the incidence of cardiovascular disease (CVD) and cancer has also presented an increasing tendency. These two different diseases, which share so...

    Authors: Ming Yang, Tiepeng Li, Shujin Guo, Kangping Song, Chuhui Gong, Ning Huang, Dejiang Pang and Hengyi Xiao
    Citation: Journal of Translational Medicine 2024 22:50
  36. Acute lung injury (ALI) is a complex disease with numerous causes. This review begins with a discussion of disease development from direct or indirect pulmonary insults, as well as varied pathogenesis. The het...

    Authors: Jianguo Zhang, Yumeng Guo, Michael Mak and Zhimin Tao
    Citation: Journal of Translational Medicine 2024 22:25
  37. p value is the most common statistic reported in scientific research articles. Choosing the conventional threshold of 0.05 commonly used for the p value in research articles, is unfounded. Many researchers hav...

    Authors: Farrokh Habibzadeh
    Citation: Journal of Translational Medicine 2024 22:16
  38. Syphilis, a sexually transmitted disease (STD) caused by Treponema pallidum (T. pallidum), has had a worldwide resurgence in recent years and remains a public health threat. As such, there has been a great deal o...

    Authors: Shun Xiong, Zhaoping Liu, Xiaohong Zhang, Shaobin Huang, Xuan Ding, Jie Zhou, Jiangchen Yao, Weiwei Li, Shuangquan Liu and Feijun Zhao
    Citation: Journal of Translational Medicine 2023 21:917
  39. With the development of cancer precision medicine, a huge amount of high-dimensional cancer information has rapidly accumulated regarding gene alterations, diseases, therapeutic interventions and various annot...

    Authors: Wei Jiang, Peng-Ying Wang, Qi Zhou, Qiu-Tong Lin, Yao Yao, Xun Huang, Xiaoming Tan, Shihui Yang, Weicai Ye, Yuedong Yang and Yun-Juan Bao
    Citation: Journal of Translational Medicine 2023 21:885
  40. Asbestos lung content is regarded as the most reliable tool for causal attribution of malignant mesothelioma (MM) to previous asbestos exposures. However, there is a lack of studies on asbestos burden in lungs...

    Authors: S. D. Visonà, B. Bertoglio, C. Favaron, S. Capella, E. Belluso, C. Colosio, S. Villani, T. Ivic-Pavlicic and E. Taioli
    Citation: Journal of Translational Medicine 2023 21:875
  41. The spread of COVID-19 has brought challenges to health, social and economic systems around the world. With little to no prior immunity in the global population, transmission has been driven primarily by human...

    Authors: Jamie D. Mullineaux, Baptiste Leurent and Takoua Jendoubi
    Citation: Journal of Translational Medicine 2023 21:848
  42. Cardiovascular disease (CVD) is a major complication in type 1 diabetes mellitus (T1D) patients. Previous studies have suggested that statins may be helpful for prevention of CVD in T1D, but there are limited ...

    Authors: Joonsang Yoo, Jimin Jeon, Minyoul Baek, Sun Ok Song and Jinkwon Kim
    Citation: Journal of Translational Medicine 2023 21:806
  43. The 70-gene signature (70-GS, MammaPrint) test has been recommended by the main guidelines to evaluate prognosis and chemotherapy benefit of hormonal receptor positive human epidermal receptor 2 negative (HR +...

    Authors: Bo Pan, Ying Xu, Ru Yao, Xi Cao, Xingtong Zhou, Zhixin Hao, Yanna Zhang, Changjun Wang, Songjie Shen, Yanwen Luo, Qingli Zhu, Xinyu Ren, Lingyan Kong, Yidong Zhou and Qiang Sun
    Citation: Journal of Translational Medicine 2023 21:798
  44. Although chronic inflammation, oxidative stress, airway remodeling, and protease-antiprotease imbalance have been implicated in chronic obstructive pulmonary disease (COPD), the exact pathogenesis is still obs...

    Authors: Beibei Li, Jiajun Zhang, Hui Dong, Xueyan Feng, Liang Yu, Jinyuan Zhu and Jin Zhang
    Citation: Journal of Translational Medicine 2023 21:790

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