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Cardiovascular, Metabolic and Lipoprotein Translation

Section edited by Nehal N. Mehta and Tommaso Angelone
© Juan Gärtner/ stock.adob

This section aims to speed mechanistic understanding, development of novel diagnostics and potential therapeutic targets within cardiovascular, metabolic diseases and lipoprotein diseases. The section is open to experiments involving cellular models, animal models, observational studies and clinical trials that are distinguished for their novelty in approach, design or indication, timeliness, and unique ability to translate laboratory concepts from the bench to the bedside.

Highest priority will be given to those manuscripts which are specifically focused on cardiovascular, metabolic and lipid disorders which enrich understanding of disease mechanism, novel therapeutics and state-of-the-art scientific technique.

Featured articles


Immune cell phenotyping in low blood volumes for assessment of cardiovascular disease risk, development, and progression: a pilot study

Research | Yvonne Baumer et al


Comprehensive analysis of differential immunocyte infiltration and the potential ceRNA networks during epicardial adipose tissue development in congenital heart disease

Research | Li Ma et al


Extracellular vesicles in diabetes mellitus induce alterations in endothelial cell morphology and migration​​​​​​​

Research | Sharon F Wu et al

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  1. Arteriovenous fistula (AVF) maturation is a process involving remodeling of venous arm of the AVFs. It is a challenge to balance adaptive AVF remodeling and neointima formation. In this study we temporally con...

    Authors: Qunying Guo, Guang Chen, Hunter Cheng, Ying Qing, Luan Truong, Quan Ma, Yun Wang and Jizhong Cheng
    Citation: Journal of Translational Medicine 2022 20:543
  2. The crosstalk of purine biosynthesis and metabolism exists to balance the cell energy production, proliferation, survival and cytoplasmic environment stability, but disorganized mechanics of with respect to de...

    Authors: Ge Wang, Rongjun Zou, Libao Liu, Zongtao Wang, Zengxiao Zou, Songtao Tan, Wenliu Xu and Xiaoping Fan
    Citation: Journal of Translational Medicine 2022 20:532
  3. Cardiac mesenchymal stromal cells (C-MSC) were recently shown to differentiate into adipocytes and myofibroblasts to promote the aberrant remodeling of cardiac tissue that characterizes arrhythmogenic cardiomy...

    Authors: Angela S. Maione, Pawan Faris, Lara Iengo, Valentina Catto, Luca Bisonni, Francesco Lodola, Sharon Negri, Michela Casella, Anna Guarino, Gianluca Polvani, Marina Cerrone, Claudio Tondo, Giulio Pompilio, Elena Sommariva and Francesco Moccia
    Citation: Journal of Translational Medicine 2022 20:522
  4. Abdominal aortic aneurysm (AAA) represents the serious vascular degenerative disorder, which causes high incidence and mortality. Alpha-ketoglutarate (AKG), a crucial metabolite in the tricarboxylic acid (TCA)...

    Authors: Junjun Liu, Mingyuan Liu, Jiaxuan Feng, Hongqiao Zhu, Jianlie Wu, Heng Zhang, Shun Xiao, Zaiping Jing, Jian Zhou, Haitao Niu and Mingjin Guo
    Citation: Journal of Translational Medicine 2022 20:461
  5. This study incorporates the results of subgroup analyses of currently published randomized controlled trials (RCTs) and real-world cohort studies to compare the effectiveness and safety of new direct oral anti...

    Authors: Xuedong Jia, Zhao Yin, Wan Zhang, Shuzhang Du and Jian Kang
    Citation: Journal of Translational Medicine 2022 20:441
  6. Atrial fibrosis plays a critical role in the development of atrial fibrillation (AF). Exosomes are a promising cell-free therapeutic approach for the treatment of AF. The purposes of this study were to explore...

    Authors: Hongting Hao, Sen Yan, Xinbo Zhao, Xuejie Han, Ning Fang, Yun Zhang, Chenguang Dai, Wenpeng Li, Hui Yu, Yunlong Gao, Dingyu Wang, Qiang Gao, Yu Duan, Yue Yuan and Yue Li
    Citation: Journal of Translational Medicine 2022 20:407
  7. Clarkson disease (monoclonal gammopathy-associated idiopathic systemic capillary leak syndrome, ISCLS) is a rare idiopathic condition marked by transient, relapsing-remitting episodes of systemic microvascular...

    Authors: Zhihui Xie, Magne Børset, Kjell Svéen, Ole Wilhelm Bøe, Eunice C. Chan, Justin B. Lack, Katherine M. Hornick, Franco Verlicchi, A. Robin Eisch, Remo Melchio, Arkadiusz Z. Dudek and Kirk M. Druey
    Citation: Journal of Translational Medicine 2022 20:380
  8. The purpose of this study was to observe the harm of circadian misalignment (CM), caused by an inverted photoperiod (IP), on the hearts of the adolescent Wistar rats, and to explore the mechanisms leading to h...

    Authors: YunLei Wang, YuanYuan Hou, ShaoFei Song, Yao Zuo, Yan Yu, YaFei Chi and Tong Zhang
    Citation: Journal of Translational Medicine 2022 20:352
  9. Asprosin, a newly discovered adipokine, is a C-terminal cleavage product of profibrillin. Asprosin has been reported to participate in lipid metabolism and cardiovascular disease, but its role in atherogenesis...

    Authors: Jin Zou, Can Xu, Zhen-Wang Zhao, Shan-Hui Yin and Gang Wang
    Citation: Journal of Translational Medicine 2022 20:337
  10. The immune system plays a vital role in the pathophysiology of acute myocardial infarction (AMI). However, the exact immune related mechanism is still unclear. This research study aimed to identify key immune-...

    Authors: Peng-Fei Zheng, Qiong-Chao Zou, Lu-Zhu Chen, Peng Liu, Zheng-Yu Liu and Hong-Wei Pan
    Citation: Journal of Translational Medicine 2022 20:321
  11. Cardiovascular diseases (CVDs) are a significant cause of mortality worldwide and are characterized by severe atherosclerosis (AS) in patients. However, the molecular mechanism of AS formation remains elusive....

    Authors: Jiaxin Hu, Ying Zhang, Liaoping Hu, Haiting Chen, Han Wu, Jianzhou Chen, Jun Xie, Biao Xu and Zhonghai Wei
    Citation: Journal of Translational Medicine 2022 20:319
  12. Increasing evidence indicates that myocardial oxidative injury plays a crucial role in the pathophysiology of cardiac hypertrophy (CH) and heart failure (HF). The active component of rhubarb, rhein exerts sign...

    Authors: Wei Lu, Hongqiao Zhu, Jiawen Wu, Sheng Liao, Guobing Cheng and Xiaoyang Li
    Citation: Journal of Translational Medicine 2022 20:305
  13. Heart failure (HF) is a global leading cause of mortality despite implementation of guideline directed therapy which warrants a need for novel treatment strategies. Proof-of-concept clinical trials of anakinra...

    Authors: Benjamin Van Tassell, Virginia Mihalick, Georgia Thomas, Amr Marawan, Azita H. Talasaz, Juan Lu, Le Kang, Amy Ladd, Juan Ignacio Damonte, Dave L. Dixon, Roshanak Markley, Jeremy Turlington, Emily Federmann, Marco Giuseppe Del Buono, Giuseppe Biondi-Zoccai, Justin M. Canada…
    Citation: Journal of Translational Medicine 2022 20:270
  14. Heart failure (HF), as the leading cause of death, is continuing to increase along with the aging of the general population all over the world. Identification of diagnostic biomarkers for early detection of HF...

    Authors: Lu Qian, Qian Zhao, Ping Yu, Jinhui Lü, Yuefan Guo, Xin Gong, Yuanyuan Ding, Shanshan Yu, Lieying Fan, Huimin Fan, Yuzhen Zhang, Zhongmin Liu, Hongzhuan Sheng and Zuoren Yu
    Citation: Journal of Translational Medicine 2022 20:267
  15. Calcific aortic valve disease (CAVD) is the most commonly valvular disease in the western countries initiated by inflammation and abnormal calcium deposition. Currently, there is no clinical drug for CAVD. Neu...

    Authors: Yan Liu, Peng Jiang, Liqin An, Mengying Zhu, Jin Li, Yue Wang, Qin Huang, Yi Xiang, Xiaorong Li, Qiong Shi and Yaguang Weng
    Citation: Journal of Translational Medicine 2022 20:167
  16. Neointimal hyperplasia induced by interventional surgery can lead to progressive obliteration of the vascular lumen, which has become a major factor affecting prognosis. The rate of re-endothelialization is kn...

    Authors: Lei Li, Yan Gao, Zhenchuan Liu, Chenglai Dong, Wenli Wang, Kaiqin Wu, Shaorui Gu and Yongxin Zhou
    Citation: Journal of Translational Medicine 2022 20:28
  17. Cardiac fibrosis, a well-known major pathological process that ultimately leads to heart failure, has attracted increasing attention and focus in recent years. A large amount of research indicates that long no...

    Authors: Zhuowang Ge, Chengye Yin, Yingze Li, Ding Tian, Yin Xiang, Qianhui Li, Yong Tang and Yachen Zhang
    Citation: Journal of Translational Medicine 2022 20:7
  18. Non-valvular atrial fibrillation (AF) is the most common type of cardiac arrhythmia. AF is caused by electrophysiological abnormalities and alteration of atrial tissues, which leads to the generation of abnorm...

    Authors: Panjaree Siwaponanan, Pontawee Kaewkumdee, Wilasinee Phromawan, Suthipol Udompunturak, Nusara Chomanee, Kamol Udol, Kovit Pattanapanyasat and Rungroj Krittayaphong
    Citation: Journal of Translational Medicine 2022 20:4
  19. Abdominal aortic aneurysm (AAA), an irreversible cardiovascular disease prevalent in the artery, causes the increase of the aneurysm diameter over time, and is a fatal phenomenon inducing sidewall rupture. Lon...

    Authors: Tianming Le, Xin He, Jianhua Huang, Shuai Liu, Yang Bai and Kemin Wu
    Citation: Journal of Translational Medicine 2021 19:466
  20. Restenosis after angioplasty is a major challenge for the treatment of coronary artery diseases. Facilitation of vascular smooth muscle cell (VSMC) apoptosis may be an attractive approach to decrease the incid...

    Authors: Xinxin Zhang, Xiangyu Xu, Li Lu, Xiaoning Wan, Yating Qin, Weibin Ruan, Chao Lv, Lin He and Xiaomei Guo
    Citation: Journal of Translational Medicine 2021 19:395
  21. Little is known regarding the functional role of microRNA-193-3p (miR-193-3p) in sepsis. Hence, the aim of the present study was to investigate the effect of miR-193-3p on myocardial injury in mice with sepsis...

    Authors: Jianyuan Pan, Buse Alexan, Dorn Dennis, Chiristine Bettina, Laeuf Ilona Mariya Christoph and Yongqin Tang
    Citation: Journal of Translational Medicine 2021 19:386
  22. Radiation therapy is integral to effective thoracic cancer treatments, but its application is limited by sensitivity of critical organs such as the heart. The impacts of acute radiation-induced damage and its ...

    Authors: Molykutty J. Aryankalayil, Shannon Martello, Michelle A. Bylicky, Sunita Chopra, Jared M. May, Aman Shankardass, Laurel MacMillan, Landy Sun, Jaleal Sanjak, Claire Vanpouille-Box, Iris Eke and C. Norman Coleman
    Citation: Journal of Translational Medicine 2021 19:336
  23. Understanding long-term patterns (trajectories) of cardiovascular diseases (CVD) risk and identifying different sub-groups with the same underlying risk patterns could help facilitate targeted cardiovascular p...

    Authors: Fatemeh Koohi, Nooshin Ahmadi, Farzad Hadaegh, Siavash Safiee, Fereidoun Azizi and Davood Khalili
    Citation: Journal of Translational Medicine 2021 19:309
  24. Peripheral arterial disease (PAD) is accompanied by myopathy characterized by mitochondrial dysfunction. The aim of this experimental study was to investigate the effect of revascularization procedures on mito...

    Authors: Alexandra Gratl, Dominik Pesta, Leonhard Gruber, Fiona Speichinger, Ben Raude, Safwan Omran, Andreas Greiner and Jan Paul Frese
    Citation: Journal of Translational Medicine 2021 19:244
  25. Inflammation and oxidative stress form a vicious circle in atherosclerosis. Oxidative stress can have detrimental effects on T cells. A unique subset of CD4+ T cells, known as regulatory T (Treg) cells, has been ...

    Authors: Anna K. Lundberg, Rosanna W. S. Chung, Louise Zeijlon, Gustav Fernström and Lena Jonasson
    Citation: Journal of Translational Medicine 2021 19:241
  26. Myocardial injury of ST-segment elevation myocardial infarction (STEMI) initiates an intense inflammatory response that contributes to further damage and is a predictor of increased risk of death or heart fail...

    Authors: M. Samsonov, V. Bogin, B. W. Van Tassell and A. Abbate
    Citation: Journal of Translational Medicine 2021 19:169
  27. Type 1 diabetes (T1DM) is associated with premature cardiovascular disease (CVD) and a pro-inflammatory state whilst the proangiogenic miR-126-3p/-5p may play a role in CVD. Animal studies established miR-126 ...

    Authors: David J. Coulson, Sherin Bakhashab, Jevi Septyani Latief and Jolanta U. Weaver
    Citation: Journal of Translational Medicine 2021 19:140
  28. Lipoprotein glomerulopathy (LPG) is a rare autosomal dominant kidney disease that is most commonly caused by mutations in ApoE Kyoto (p.R43C) and ApoE Sendai (p.R163P). Differences in phenotype among the vario...

    Authors: Hongyan Wu, Jing Yang, Yun-Qiang Liu, Song Lei, Mei Yang, Zhi Yang, Yuan Yang and Zhangxue Hu
    Citation: Journal of Translational Medicine 2021 19:97
  29. The purpose of this study was to investigate the utility of BNP, hsTroponin-I, interleukin-6, sST2, and galectin-3 in predicting the future development of new onset heart failure with preserved ejection fracti...

    Authors: Chris J. Watson, Joe Gallagher, Mark Wilkinson, Adam Russell-Hallinan, Isaac Tea, Stephanie James, James O’Reilly, Eoin O’Connell, Shuaiwei Zhou, Mark Ledwidge and Ken McDonald
    Citation: Journal of Translational Medicine 2021 19:61
  30. COronaVIrus Disease 19 (COVID-19) is caused by the infection of the Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2). Although the main clinical manifestations of COVID-19 are respiratory, many pat...

    Authors: S. Greco, A. Madè, C. Gaetano, Y. Devaux, C. Emanueli and F. Martelli
    Citation: Journal of Translational Medicine 2020 18:408
  31. The gut microbiota was shown to play a crucial role in the development of vascular dysfunction, and the bacterial composition differed between healthy controls and coronary artery disease patients. The goal of...

    Authors: Honghong Liu, Ran Tian, Hui Wang, Siqin Feng, Hanyu Li, Ying Xiao, Xiaodong Luan, Zhiyu Zhang, Na Shi, Haitao Niu and Shuyang Zhang
    Citation: Journal of Translational Medicine 2020 18:382
  32. Elevated lipoprotein(a) [Lp(a)] and fibrinogen (Fib) are both associated with coronary artery disease (CAD). The atherogenicity of Lp(a) can be partly due to the potentially antifibrinolytic categories. We hyp...

    Authors: Yan Zhang, Jing-Lu Jin, Ye-Xuan Cao, Hui-Hui Liu, Hui-Wen Zhang, Yuan-Lin Guo, Na-Qiong Wu, Ying Gao, Qi Hua, Yan-Fang Li, Rui-Xia Xu, Chuan-Jue Cui, Geng Liu, Qian Dong, Jing Sun and Jian-Jun Li
    Citation: Journal of Translational Medicine 2020 18:373
  33. High burden of chronic cardio-metabolic disorders including type 2 diabetes mellitus (T2DM), chronic kidney disease (CKD), and cardiovascular disease (CVD) have been reported in the Middle East and North Afric...

    Authors: Samaneh Asgari, Fatemeh Moosaie, Davood Khalili, Fereidoun Azizi and Farzad Hadaegh
    Citation: Journal of Translational Medicine 2020 18:267
  34. Aim of this study was to assess changes in cardiac morphometric parameters at different stages of pulmonary arterial hypertension (PAH) using a monocrotaline-induced rat model.

    Authors: Mateusz K. Hołda, Elżbieta Szczepanek, Joanna Bielawska, Natalia Palka, Dorota Wojtysiak, Paulina Frączek, Michał Nowakowski, Natalia Sowińska, Zbigniew Arent, Piotr Podolec and Grzegorz Kopeć
    Citation: Journal of Translational Medicine 2020 18:262
  35. Inflammation-related atherosclerotic peripheral vascular disease is a major end organ complication of diabetes mellitus that results in devastating morbidity and mortality. Extracellular vesicles (EVs) are nan...

    Authors: Sharon F. Wu, Nicole Noren Hooten, David W. Freeman, Nicolle A. Mode, Alan B. Zonderman and Michele K. Evans
    Citation: Journal of Translational Medicine 2020 18:230
  36. Extracorporeal circulation during major cardiac surgery triggers a systemic inflammatory response affecting the clinical course and outcome. Recently, extracellular vesicle (EV) research has shed light onto a ...

    Authors: Lukas Wisgrill, Christian Lamm, Lena Hell, Johannes Thaler, Angelika Berger, Rene Weiss, Viktoria Weber, Harald Rinoesl, Michael J. Hiesmayr, Andreas Spittler and Martin H. Bernardi
    Citation: Journal of Translational Medicine 2020 18:202
  37. Glutamate, a key intermediate in myocardial metabolism, may enhance myocardial recovery after ischemia and possibly reduce the incidence and severity of postoperative heart failure in coronary artery bypass su...

    Authors: Huiqi Jiang, Jonas Holm, Mårten Vidlund, Farkas Vanky, Örjan Friberg, Yanqi Yang and Rolf Svedjeholm
    Citation: Journal of Translational Medicine 2020 18:193
  38. To detect the development, function and therapeutic potential of epicardial adipose tissue (EAT); analyze a related gene expression dataset, including data from neonates, infants, and children with congenital ...

    Authors: Li Ma, Wanting Shi, Xun Ma, Minghui Zou, Weidan Chen, Wenlei Li, Rongjun Zou and Xinxin Chen
    Citation: Journal of Translational Medicine 2020 18:111
  39. Venoarterial extracorporeal membrane oxygenation (VA ECMO) is widely used in the treatment of circulatory failure, but repeatedly, its negative effects on the left ventricle (LV) have been observed. The purpos...

    Authors: Pavel Hála, Mikuláš Mlček, Petr Ošťádal, Michaela Popková, David Janák, Tomáš Bouček, Stanislav Lacko, Jaroslav Kudlička, Petr Neužil and Otomar Kittnar
    Citation: Journal of Translational Medicine 2020 18:75
  40. Inflammation within the perivascular adipose tissue (PVAT) in obesity plays an important role in cardiovascular disorders. C-reactive protein (CRP) level in obesity patients is significantly increased and asso...

    Authors: Jia-Yuan Chen, Xiao-Lin Zhu, Wen-Hao Liu, Yong Xie, Hai-Feng Zhang, XiaoQiao Wang, Ru Ying, Zhi-Teng Chen, Mao-Xiong Wu, Qiong Qiu, Jing-Feng Wang and Yang-Xin Chen
    Citation: Journal of Translational Medicine 2020 18:68
  41. Bioresorbable scaffold (BRS) Absorb™ clinical use has been stopped due to higher rate of device thrombosis. Scaffold struts persist longer than 2 years in the vessel wall. Second generation devices are being d...

    Authors: Viktor Kočka, Petr Toušek, Martin Kozel, Andrea Buono, Martin Hajšl, Libor Lisa, Tomáš Buděšínský, Martin Malý and Petr Widimský
    Citation: Journal of Translational Medicine 2020 18:33
  42. Cardiovascular disease (CVD) is the leading cause of death in the world. Given the role of immune cells in atherosclerosis development and progression, effective methods for characterizing immune cell populati...

    Authors: Yvonne Baumer, Cristhian A. Gutierrez-Huerta, Ankit Saxena, Pradeep K. Dagur, Steven D. Langerman, Kosuke Tamura, Joniqua N. Ceasar, Marcus R. Andrews, Valerie Mitchell, Billy S. Collins, Quan Yu, Heather L. Teague, Martin P. Playford, Christopher K. E. Bleck, Nehal N. Mehta, J. Philip McCoy…
    Citation: Journal of Translational Medicine 2020 18:29
  43. Tetralogy of Fallot (ToF) and Atrial Septal Defects (ASD) are the most common types of congenital heart diseases and a major cause of childhood morbidity and mortality. Cardiopulmonary bypass (CPB) is used dur...

    Authors: Federica Raggi, Davide Cangelosi, Pamela Becherini, Fabiola Blengio, Martina Morini, Massimo Acquaviva, Maria Luisa Belli, Giuseppe Panizzon, Giuseppe Cervo, Luigi Varesio, Alessandra Eva and Maria Carla Bosco
    Citation: Journal of Translational Medicine 2020 18:21
  44. The objectives of the study were to characterize and quantify cellular inflammation and structural remodeling of human atria and correlate findings with molecular markers of inflammation and patient surrogate ...

    Authors: Christie M. Aguiar, Kareem Gawdat, Stephanie Legere, Jean Marshall, Ansar Hassan, Petra C. Kienesberger, Thomas Pulinilkunnil, Mathieu Castonguay, Keith R. Brunt and Jean-Francois Legare
    Citation: Journal of Translational Medicine 2019 17:413
  45. Atherosclerosis preferentially develops in regions of disturbed flow (DF). Emerging evidence indicates that yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ), which are...

    Authors: Dandan Liu, Hang Lv, Qi Liu, Yanli Sun, Shenglong Hou, Lu Zhang, Mengyue Yang, Baihe Han, Gang wang, Xuedong Wang, Wenjuan Du, Honggang Nie, Ruoxi Zhang, Xingtao Huang, Jingbo Hou and Bo Yu
    Citation: Journal of Translational Medicine 2019 17:378
  46. Adipokines in serum derive mainly from subcutaneous and visceral adipose tissues. Epicardial adipose tissue (EAT), being a relatively small but unique fat depot, probably does not make an important contributio...

    Authors: Kacper Toczylowski, Tomasz Hirnle, Dorota Harasiuk, Piotr Zabielski, Anna Lewczuk, Iwona Dmitruk, Monika Ksiazek, Artur Sulik, Jan Gorski, Adrian Chabowski and Marcin Baranowski
    Citation: Journal of Translational Medicine 2019 17:310
  47. HMG-CoA reductase inhibitors (statins) are cholesterol-lowering drugs widely used to treat hypercholesterolemia and prevent cardiovascular disease. Statins are generally well tolerated, but adverse reactions m...

    Authors: Estela Lorza-Gil, Marta García-Arevalo, Bianca Cristine Favero, Maria Cristina C. Gomes-Marcondes and Helena C. F. Oliveira
    Citation: Journal of Translational Medicine 2019 17:285
  48. Spaceflight or microgravity conditions cause myocardial atrophy and dysfunction, contributing to post-flight orthostatic intolerance. However, the underlying mechanisms remain incompletely understood and preve...

    Authors: Liwen Liang, Wenyi Yuan, Lina Qu, Huili Li, Lulu Zhang, Guo-Chang Fan and Tianqing Peng
    Citation: Journal of Translational Medicine 2019 17:279
  49. Neointimal hyperplasia and its related arterial stiffness are the crucial pathophysiological features in atherosclerosis and in-stent restenosis. Cluster of differentiation 147 (CD147), a member of the immunog...

    Authors: Kisoo Pahk, Hyojin Noh, Chanmin Joung, Mi Jang, Hwa Young Song, Kyung Won Kim, Kihoon Han, Jong-Ik Hwang, Sungeun Kim and Won-Ki Kim
    Citation: Journal of Translational Medicine 2019 17:274

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