Characteristic | Training cohort (Nā=ā310) | Validation cohort (Nā=ā134) | External test cohort (Nā=ā81) | ||||||
---|---|---|---|---|---|---|---|---|---|
ALN+ (Nā=ā221) | ALNā (Nā=ā89) | P | ALN+ (Nā=ā95) | ALNā (Nā=ā39) | P | ALN+ (Nā=ā52) | ALNā (Nā=ā29) | P | |
Age (years) | 49.74āĀ±ā10.88 | 49.21āĀ±ā9.76 | 0.691 | 50.42āĀ±ā9.82 | 49.54āĀ±ā9.31 | 0.632 | 50.63āĀ±ā9.31 | 50.00āĀ±ā9.55 | 0.771 |
Pathological type, No (%) | Ā | Ā | 0.644 | Ā | Ā | 0.657 | Ā | Ā | 1.000 |
āIDCa | 207 (93.67) | 81 (91.01) | Ā | 85 (89.47) | 37 (94.87) | Ā | 51 (98.08) | 29 (100.00) | Ā |
āILCb | 5 (2.26) | 3 (3.37) | Ā | 3 (3.16) | 0 (0.00) | Ā | 1 (1.92) | 0 (0.00) | Ā |
āOthers | 9 (4.07) | 5 (5.62) | Ā | 7 (7.37) | 2 (5.13) | Ā | 0 (0.00) | 0 (0.00) | Ā |
Node long axis (cm) | 1.45āĀ±ā0.68 | 1.24āĀ±ā0.54 | 0.008 | 1.38āĀ±ā0.65 | 1.21āĀ±ā0.52 | 0.147 | 1.59āĀ±ā0.75 | 1.47āĀ±ā0.58 | 0.436 |
Node short axis (cm) | 0.74āĀ±ā0.38 | 0.55āĀ±ā0.18 | <ā0.001 | 0.72āĀ±ā0.40 | 0.53āĀ±ā0.18 | 0.003 | 0.82āĀ±ā0.35 | 0.70āĀ±ā0.28 | 0.121 |
Cortical thickness (cm) | 0.50āĀ±ā0.60 | 0.19āĀ±ā0.12 | <ā0.001 | 0.52āĀ±ā0.51 | 0.20āĀ±ā0.12 | <ā0.001 | 0.49āĀ±ā0.34 | 0.22āĀ±ā0.22 | <ā0.001 |
Cortical thickening, No (%) | Ā | Ā | <ā0.001 | Ā | Ā | 0.310 | Ā | Ā | 0.549 |
āYes | 39 (17.65) | 3 (3.37) | Ā | 17 (17.89) | 4 (10.26) | Ā | 3 (5.77) | 0 (0.00) | Ā |
āNo | 182 (82.35) | 86 (96.63) | Ā | 78 (82.11) | 35 (89.74) | Ā | 49 (94.23) | 29 (100.00) | Ā |
Medulla absence, No (%) | Ā | Ā | <ā0.001 | Ā | Ā | 0.054 | Ā | Ā | 0.001 |
āYes | 45 (20.36) | 3 (3.37) | Ā | 27 (28.42) | 5 (12.82) | Ā | 19 (36.54) | 1 (3.45) | Ā |
āNo | 176 (79.64) | 86 (96.63) | Ā | 68 (71.58) | 34 (87.18) | Ā | 33 (63.46) | 28 (96.55) | Ā |
T stage, No (%) | Ā | Ā | 0.551 | Ā | Ā | 0.024 | Ā | Ā | 0.009 |
āT1 | 17 (7.69) | 5 (5.62) | Ā | 7 (7.37) | 5 (12.82) | Ā | 14 (26.92) | 9 (31.03) | Ā |
āT2 | 130 (58.82) | 47 (52.81) | Ā | 62 (65.26) | 17 (43.59) | Ā | 26 (50.00) | 19 (65.52) | Ā |
āT3 | 64 (28.96) | 31 (34.83) | Ā | 22 (23.16) | 10 (25.64) | Ā | 12 (23.08) | 0 (0.00) | Ā |
āT4 | 10 (4.52) | 6 (6.74) | Ā | 4 (4.21) | 7 (17.95) | Ā | 0 (0.00) | 1 (3.45) | Ā |
N stage, No (%) | Ā | Ā | <ā0.001 | Ā | Ā | 0.001 | Ā | Ā | <ā0.001 |
āN1 | 140 (63.35) | 78 (87.64) | Ā | 60 (63.16) | 37 (94.87) | Ā | 25 (48.08) | 26 (89.66) | Ā |
āN2 | 43 (19.46) | 10 (11.24) | Ā | 18 (18.95) | 1 (2.56) | Ā | 11 (21.15) | 3 (10.34) | Ā |
āN3 | 38 (17.19) | 1 (1.12) | Ā | 17 (17.89) | 1 (2.56) | Ā | 16 (30.77) | 0 (0.00) | Ā |
ER status, No (%) | Ā | Ā | 0.038 | Ā | Ā | 0.011 | Ā | Ā | 0.401 |
āPositive | 140 (63.35) | 45 (50.56) | Ā | 66 (69.47) | 18 (46.15) | Ā | 37 (71.15) | 18 (62.07) | Ā |
āNegative | 81 (36.65) | 44 (49.44) | Ā | 29 (30.53) | 21 (53.85) | Ā | 15 (28.85) | 11 (37.93) | Ā |
HER2 status, No (%) | Ā | Ā | 0.006 | Ā | Ā | 0.034 | Ā | Ā | 0.031 |
āPositive | 84 (38.01) | 43 (48.31) | Ā | 28 (29.47) | 19 (48.72) | Ā | 16 (30.77) | 16 (55.17) | Ā |
āNegative | 137 (61.99) | 46 (51.69) | Ā | 67 (70.53) | 20 (51.28) | Ā | 36 (69.23) | 13 (44.83) | Ā |
Ki-67ā> 20%, No (%) | Ā | Ā | 0.010 | Ā | Ā | 0.016 | Ā | Ā | 0.576 |
āYes | 116 (52.49) | 61 (68.54) | Ā | 44 (46.32) | 27 (69.23) | Ā | 32 (61.54) | 16 (55.17) | Ā |
āNo | 105 (47.51) | 28 (31.46) | Ā | 51 (53.68) | 12 (30.77) | Ā | 20 (38.46) | 13 (44.83) | Ā |
NAC Regimens, No (%) | Ā | Ā | 0.152 | Ā | Ā | 0.280 | Ā | Ā | 0.161 |
āAC-T | 41 (18.55) | 21 (23.60) | Ā | 16 (16.84) | 5 (12.82) | Ā | 9 (17.31) | 4 (13.79) | Ā |
āAC-TH | 27 (12.22) | 13 (14.61) | Ā | 10 (10.53) | 3 (7.79) | Ā | 5 (9.62) | 2 (6.90) | Ā |
āAC-THP | 11 (4.98) | 2 (2.25) | Ā | 1 (1.05) | 1 (2.56) | Ā | 0 (0.00) | 0 (0.00) | Ā |
āAT | 22 (9.95) | 3 (3.37) | Ā | 18 (18.95) | 6 (15.38) | Ā | 6 (11.54) | 1 (3.45) | Ā |
āTAC | 77 (34.84) | 21 (23.60) | Ā | 31 (32.63) | 7 (17.95) | Ā | 22 (42.31) | 8 (27.59) | Ā |
āTCb | 5 (2.26) | 3 (3.37) | Ā | 3 (3.16) | 2 (5.13) | Ā | 0 (0.00) | 0 (0.00) | Ā |
āTCbH | 7 (3.17) | 5 (5.62) | Ā | 4 (4.21) | 3 (7.69) | Ā | 1 (1.92) | 0 (0.00) | Ā |
āTCbHP | 15 (6.79) | 9 (10.11) | Ā | 4 (4.21) | 3 (7.69) | Ā | 2 (3.85) | 2 (6.90) | Ā |
āTH | 2 (0.90) | 1 (1.12) | Ā | 1 (1.05) | 0 (0.00) | Ā | 0 (0.00) | 1 (3.45) | Ā |
āTHP | 14 (6.33) | 11 (12.36) | Ā | 7 (7.37) | 9 (23.08) | Ā | 7 (13.46) | 11 (37.93) | Ā |