Fig. 9

Decision thresholds according to levels of circulating histones H2B and H3 in plasma for early management of patients with sepsis. Values below 190 ng/mL for H2B are associated with increased survival probability. This result is reinforced if patients showed a value below 163 ng/mL of circulating histone H3. However, values higher than 190 ng/mL of H2B are associated with high risk of renal failure in septic shock patients and predictive of fatal outcome. When the levels of circulating histone H2B were higher than 335.50 ng/mL, there was an increased risk of developing DIC in patients. In line with this idea, we found that values for histone H2B above 435.61 ng/ml were indicative of need for vital support therapies