Fig. 6From: Validation of circulating histone detection by mass spectrometry for early diagnosis, prognosis, and management of critically ill septic patientsLevels of circulating histones H2B and H3 in plasma of septic shock patients with and without support therapies. Circulating histones were measured using LC–MS/MS with spike-in isotopic labelled peptides for absolute quantification. Groups were compared via Kruskal–Wallis test. *P < 0.001. The number of subjects analyzed were septic shock cases without vital support therapy (n = 41); septic shock cases with IVM (n = 14) and septic shock cases with IVM + RTT (n = 14)Back to article page