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Fig. 6 | Journal of Translational Medicine

Fig. 6

From: Validation of circulating histone detection by mass spectrometry for early diagnosis, prognosis, and management of critically ill septic patients

Fig. 6

Levels of circulating histones H2B and H3 in plasma of septic shock patients with and without support therapies. Circulating histones were measured using LC–MS/MS with spike-in isotopic labelled peptides for absolute quantification. Groups were compared via Kruskal–Wallis test. *P < 0.001. The number of subjects analyzed were septic shock cases without vital support therapy (n = 41); septic shock cases with IVM (n = 14) and septic shock cases with IVM + RTT (n = 14)

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