Fig. 3From: Validation of circulating histone detection by mass spectrometry for early diagnosis, prognosis, and management of critically ill septic patientsConcentration of circulating histones H2B and H3 in plasma of ICU-controls, sepsis, and septic shock patients. Circulating histones were measured using LC–MS/MS using spike-in isotopic labelled peptides for absolute quantification. Groups were compared by the Kruskal–Wallis test. *P < 0.01. The number of subjects analyzed were ICU Controls (n = 9); Sepsis (n = 11); septic shock (SS) (n = 69)Back to article page