Fig. 1From: Validation of circulating histone detection by mass spectrometry for early diagnosis, prognosis, and management of critically ill septic patientsLevels of circulating histones H2B and H3 in plasma of ICU-controls and septic patients. Circulating histones were measured using LC–MS/MS using spike-in isotopic labelled peptides for absolute quantification. Groups were compared by U Mann Whitney test. *P < 0.001. The number of subjects analyzed were ICU Controls (n = 9) and cases [Sepsis + Septic Shock] (n = 80)Back to article page