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Table 2 Table for target MOAs, target proteins (given as UniProt symbols), effective disease areas and effective diseases of candidate drugs (*) and compounds sharing the same target MOAs according to CMAP

From: Drug repositioning targeting glutaminase reveals drug candidates for the treatment of Alzheimer’s disease patients

Drug name

Target

Target id

Disease area

Indication

Auranofin

NFkB pathway

IKBKB, PRDX5, TRPA1

Rheumatology

Rheumatoid arthritis

BAY-11–7082

NFkB pathway

RELA

Not available

Not available

Betulinic-acid

Apoptosis stimulant

NFkB pathway inhibitor

GPBAR1

Not available

Not available

Bindarit

NFkB pathway

CCL2, CCL7, CCL8

Not available

Not available

Bortezomib *

NFkB pathway

Proteasome

PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMA8, PSMB1, PSMB10, PSMB11, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9, PSMD1, PSMD2, RELA

Hematologic malignancy

Multiple myeloma

MCL

Carfilzomib

Proteasome

PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMA8, PSMB1, PSMB10, PSMB11, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9

Hematologic malignancy

Multiple myeloma

Ceritinib

ALK tyrosine kinase

ALK, FLT3, IGF1R, INSR, TSSK1B

Oncology

NSCLC

Colchicine

Microtubule organization

GLRA1, GLRA2, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8

Other

Gout

Fever

Crizotinib *

ALK tyrosine kinase

ALK, MET

Oncology

NSCLC

Curcumin

Cyclooxygenase

Histone acetyltransferase

Lipoxygenase

NFkB pathway

APP, CA1, CA12, CA14, CA2, CA4, CA6, CA9, CHRM3, CYP3A4, DNMT3B, EP300, MMP13, MMP9, NOS2, PTGS1, PTGS2, XDH

Not available

Not available

Daunorubicin

RNA synthesis

Topoisomerase

TOP2A, TOP2B

Hematologic malignancy

AML

ALL

Delanzomib

Proteasome

CMA1, CTSG, CYP3A4, ELANE

Not available

Not available

Docetaxel

Tubulin polymerization

BCL2, MAP2, MAP4, MAPT, NR1I2, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8

Oncology

Breast cancer

NSCLC

Prostate cancer

GAC

HNSCC

Doxorubicin

Topoisomerase

TOP2A

Oncology

ALL

AML

Wilm’s tumour

Breast cancer

Ovarian cancer

Hodgkin’s lymphoma

Bladder cancer

Multiple myeloma

Epirubicin

Topoisomerase

CHD1, TOP2A

Oncology

•Breast cancer

Erythromycin

NFkB pathway

MLNR

Infectious disease

Listeria

Respiratory tract infections

Skin infections

Syphilis

Amebiasis

Pelvic inflammatory disease

Chlamydia

Diphtheria

Erythrasma

Idarubicin

Topoisomerase

TOP2A

Hematologic malignancy

AML

Mepacrine

Cytokine production

NFkB pathway

TP53

PLA2G1B

Infectious disease

Giardiasis

MG-132

Proteasome

PSMB1

Not available

Not available

Mitoxantrone *

Topoisomerase

TOP2A

Neurology/psychiatry

MS

Prostate cancer

AML

NVP-TAE684

ALK tyrosine kinase

ALK, INSR

Not available

Not available

Oprozomib

Proteasome

 

Not available

Not available

Paclitaxel

Tubulin polymerization

BCL2, MAP2, MAP4, MAPT, NR1I2, TLR4, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8

oncology

Ovarian cancer

Breast cancer

NSCLC

parbendazole *

Tubulin polymerization

TUBB

Not available

Not available

Parthenolide

NFkB pathway

Not available

Not available

Not available

Ro-106–9920

NFkB pathway

Not available

Not available

Not available

Secnidazole

Acetylcholinesterase

Microtubule

Not available

Infectious disease

Protozoan infection

Teniposide

Topoisomerase

TOP2A, TOP2B

Hematologic malignancy

ALL

Topotecan

Topoisomerase

TOP1, TOP1MT

Oncology

SCLC

Cervical cancer

Ursolic-acid

ATPase

NFkB pathway

STAT pathway

HSD11B1, PLA2G1B, PTPN1, PYGM

Not available

Not available

Vinblastine

Microtubule

Tubuline polymerization

JUN, TUBA1A, TUBB, TUBD1, TUBE1, TUBG1

Oncology

Hodgkin’s lymphoma

THL

Mycosis

SLL

Testicular carcinoma

Kaposi sarcoma

Secnidazole

Acetylcholinesterase

Microtubule

Infectious disease

Protozoan infection

Teniposide

Topoisomerase

TOP2A, TOP2B

Hematologic malignancy

ALL

  1. AML acute myeloid leukaemia, ALL acute lymphoblastic leukaemia, GAC gastric adenocarcinoma, HNSCC head and neck squamous cell carcinoma, MCL mantle cell lymphoma, MS multiple sclerosis, NSCLC non-small cell lung cancer, SCLC small cell lung cancer, SLL small lymphocytic lymphoma, THL true histiocytic lymphoma