Fig. 3

Bubble plots showing the enriched functional pathways regulated by GLS knockdown and candidate drugs, based on (A) MSigDB hallmark pathways (n = 50) and (B) KEGG pathways significantly changed by GLS knockdown (n = 61). The red colour shows a larger normalised enrichment score (NES)/enrichment, and the blue colour shows a larger negative NES/repression. The size of the “bubble” represents the reliability of enrichment scores, which is calculated as -log(FDR adjusted and weighted Fisher aggregated p-value). The circle represents significant enrichments/repressions, and the triangle represents non-significant enrichment/repressions