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Fig. 3 | Journal of Translational Medicine

Fig. 3

From: Alterations in the microenvironment and the effects produced of TRPV5 in osteoporosis

Fig. 3

TRPV5 channels are distributed in osteoclasts and the apical membrane of tubular cells in the DCT and CNT. Osteoclasts are typically located in the fossa depression and primarily undergo osteolysis and phagocytosis. The TRPV5 channel is commonly distributed at the folded edge of osteoclasts and mainly performs the transport function of Ca2+. The renal tubules are primarily responsible for the reabsorption of Ca2+. TRPV5 channels exist on the apical membrane of tubular cells to transport Ca2+. When Ca2+ enters the cells, it binds with calbindin and is subsequently transported to PMCA1b or NCX1 and pumped out to the other side of the membrane. When the TRPV5 gene is deleted, the reabsorption of renal calcium is significantly reduced, and the excretion of calcium in the urine markedly increased, resulting in the disturbance of calcium levels in the body

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