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Table 5 Top 20 proteins ranked in importance measurements in LASSO, Random Forest and XGBoost

From: Proteomics and cytokine analyses distinguish myalgic encephalomyelitis/chronic fatigue syndrome cases from controls

Logistic Regression with LASSO penalty

Random Forest

XGBoost

Protein Name

Direction

Percentage

Protein Name

Direction

MDA

Protein Name

Direction

Gain

IL2-ev

Increased

46.4

CRTAC1

Decreased

2.939

CRTAC1

Decreased

0.044

CAMP

Increased

43.2

CCL5-ev

Increased

2.759

CCL5-ev

Increased

0.033

IGHA1

Decreased

40

IGF1

Decreased

2.509

CAMP

Increased

0.033

IGLV1-47

Decreased

36

NGFB-ev

Increased

2.423

IGF1

Decreased

0.022

CRTAC1

Decreased

36

CXCL8-ev

Increased

2.394

IGLV1-47

Decreased

0.021

LRG1

Decreased

30.8

IL2-ev

Increased

2.377

IL2-ev

Increased

0.020

IGF1

Decreased

28.8

CPB2

Increased

2.325

LRG1

Decreased

0.019

PVR

Decreased

24.8

IL12p70-p

Decreased

2.14

CXCL8-ev

Increased

0.018

KNG1

Increased

22.8

IGLV1-47

Decreased

1.897

IL22-p

Decreased

0.015

TUBA1B/A/C

Decreased

7.6

IGLV3-10

Decreased

1.828

TNFα-p

Increased

0.013

IGFALS

Decreased

6

IGFALS

Decreased

1.794

IGFALS

Decreased

0.012

VEGF-ev

Increased

5.2

CAMP

Increased

1.758

IGHA1

Decreased

0.012

IGLV2-11

Decreased

5.2

CCL7-ev

Increased

1.593

GSN

Decreased

0.011

C4BPB

Increased

2.4

LRG1

Decreased

1.486

TUBA1B/A/C

Decreased

0.011

BTD

Decreased

1.2

HBB

Increased

1.366

CXCL10-ev

Decreased

0.011

IL7-p

Decreased

0.4

IL15-ev

Increased

1.337

HBB

Increased

0.010

TNFα-p

Increased

0.4

TUBA1B/A/C

Decreased

1.196

MASP1

Decreased

0.009

IGKV1D-16

Increased

0.4

LCAT

Decreased

1.048

HYI

Decreased

0.009

APOC1

Increased

0.4

IGFBP3

Decreased

1.024

CCL7-ev

Increased

0.009

MBL2

Increased

0.4

PKM

Decreased

1.021

IGLV3-10

Decreased

0.009

  1. Direction is measured relative to controls. Proteins followed by “p” or “ev” come from the plasma and EV cytokines datasets respectively, all other proteins are from the plasma proteomic dataset