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Table 2 Correlations between clinical data and plasma cytokines (top) and plasma proteomics (bottom)

From: Proteomics and cytokine analyses distinguish myalgic encephalomyelitis/chronic fatigue syndrome cases from controls

Plasma cytokines

Cohort

Metadata

Correlation

P-value

Q-value

CSF2

ME/CFS

Sex (0 = female, 1 = male)

− 0.474

0.001

0.032

Control

Sex (0 = female, 1 = male)

− 0.465

0.001

0.042

ME/CFS

IBS (0 = without IBS, 1 = with IBS)

0.437

0.002

0.052

ME/CFS

BMI

0.596

0.000

0.000

Control

BMI

0.448

0.001

0.023

ME/CFS

Physical function (SF-36)

− 0.539

< 0.001

0.002

ME/CFS

Physical component summary (SF-36)

− 0.459

0.001

0.035

ME/CFS

General Fatigue (MFI-20)

0.436

0.002

0.047

Leptin

ME/CFS

Sex (0 = female, 1 = male)

− 0.414

0.003

0.086

Control

Sex (0 = female, 1 = male)

− 0.427

0.002

0.061

ME/CFS

IBS (0 = without IBS, 1 = with IBS)

0.433

0.002

0.052

ME/CFS

BMI

0.577

< 0.001

< 0.001

Control

BMI

0.475

0.001

0.018

ME/CFS

Physical function (SF-36)

− 0.558

< 0.001

0.002

ME/CFS

Physical component summary (SF-36)

− 0.445

0.001

0.035

ME/CFS

General fatigue (MFI-20)

0.439

0.002

0.047

CCL2

ME/CFS

Age

0.440

0.002

0.060

CXCL10

ME/CFS

Age

0.394

0.005

0.099

CCL11

ME/CFS

Age

0.431

0.002

0.060

TNFα

ME/CFS

BMI

0.543

< 0.001

0.001

ME/CFS

Physical function (SF-36)

− 0.508

< 0.001

0.004

ME/CFS

Physical component summary (SF-36)

− 0.432

0.002

0.035

IL1RA

ME/CFS

BMI

0.468

0.001

0.010

ME/CFS

Physical function (SF-36)

− 0.480

< 0.001

0.007

IL13

ME/CFS

Reduced activity (MFI-20)

0.482

< 0.001

0.025

Plasma proteomics

Cohort

Metadata

Correlation

P-value

Q-value

PROS1

Control

Physical component summary (SF-36)

− 0.608

< 0.001

0.008

Control

General fatigue (MFI-20)

0.590

< 0.001

0.016

Control

Vitality (SF-36)

− 0.590

< 0.001

0.015

FCRL3

Control

Vitality (SF-36)

− 0.538

< 0.001

0.039

IGHV3-23.IGHV3-30

Control

Vitality (SF-36)

0.527

< 0.001

0.039

SERPINA5

ME/CFS

General health (SF-36)

0.646

< 0.001

0.004

ME/CFS

Social functioning (SF-36)

0.593

< 0.001

0.027

CETP

Control

General fatigue (MFI-20)

0.547

< 0.001

0.032

Control

Total (MFI-20)

0.557

< 0.001

0.025

HBA1

Control

Mental fatigue (MFI-20)

− 0.558

< 0.001

0.046

Control

Total (MFI-20)

− 0.556

< 0.001

0.025