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Fig. 7 | Journal of Translational Medicine

Fig. 7

From: P21 facilitates macrophage chemotaxis by promoting CCL7 in the lung epithelial cell lines treated with radiation and bleomycin

Fig. 7

The schematic model of P21-mediated chemotaxis of macrophages by CCL7 secretion from injured epithelial cells. After IR or BLM exposure, P21 was upregulated in stressed epithelial cells and then promoted CCL7 production and secretion. Macrophages were in turn recruited by CCL7 chemokine via binding to their receptors. Polarization of M1 macrophages functioned as inflammatory effects through NF-κB/STAT1 pathway

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Journal of Translational Medicine

ISSN: 1479-5876

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