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Table 1 Clinical characteristics of VA-ECMO patients on day 1

From: The serum proteome of VA-ECMO patients changes over time and allows differentiation of survivors and non-survivors: an observational study

Parameter

VA-ECMO

Patients, n (%)

14 (100)

Survivors, n (%)

7 (50)

Age, y (IQR)

71 (57–75)

Female, n (%)

5 (36)

Duration of ICU-stay (d, IQR)

12 (7–17)

VA-ECMO Device, n (%)

 Stöckert Sorin

9 (64)

 Maquet

5 (36)

Duration of ECMO (d, IQR)

7 (6–7)

ECMO Blood Flow (l/min, IQR)

4.3 (3.3–4.6)

Indication for VA-ECMO, n (%)

 Cardiogenic shock

  Postoperative

7 (50)

  Medical

7 (50)

    eCPR

3 (21)

Coronary Heart Disease, n (%)

9 (64)

Atrial fibrillation, n (%)

7 (50)

Diabetes mellitus, n (%)

1 (7)

Hypertension, n (%)

3 (21)

Active Smoker, n (%)

2 (14)

Hypercholesterolemia, n (%)

1 (7)

Cancer, n (%)

0 (0)

Acute renal failure, n (%)

10 (71)

Continuous hemodialysis, n (%)

6 (43)

 Major bleeding, n (%)

6 (43)

Intracerebral bleeding, n (%)

1 (7)

Minor bleeding, n (%)

4 (29)

Heparin, n (%)

13 (93)

Dual anti-platelet therapy, n (%)

6 (43)

Steroids, n (%)

1 (7)

Mechanical ventilation, n (%)

14 (100)

SOFA score (IQR)

11.0 (8.0–11.0)

Hb (g/dl, IQR)

8.5 (8.3–8.9)

Platelets (× 103/µl, IQR)

109 (79–154)

Creatinine (mg/dl, IQR)

1.3 (1.0–2.5)

Urea (mg/dl, IQR)

51.0 (38.0–71.0)

Bilirubin (mg/dl, IQR)

2.2 (1.6–2.9)

AST (U/l, IQR)

157.0 (58.8–509.3)

ALT (U/l, IQR)

55.0 (21.8–123.8)

Lactate (mmol/l, IQR)

3.6 (1.5–5.3)

Leukocytes (× 103/µl, IQR)

8.9 (6.9–11.2)

CRP (mg/l, IQR)

54.1 (24.5–90.6)

IL-6 (pg/ml, IQR)

370.5 (308.5–784.8)

paO2 (mmHg, IQR)

111.0 (81.8–239.0)

paCO2 (mmHg, IQR)

38.4 (35.3–50.0)

FiO (%, IQR)

47.5 (40.0–50.0)

PEEP (mbar, IQR)

8.0 (7.0–10.0)

Respiratory rate (/min, IQR)

14.0 (11.0–18.0)

  1. Data are presented as median (interquartile range, Q1-Q3) or number of patients (%). Denominator of the percentage is the total number of subjects in the group. Parameters that were closest to the time point of blood sampling for proteome analysis are  presented. Major and minor bleeding events are presented as defined by the International Society on Thrombosis and Haemostasis [14]. Macroscopic signs of thrombosis in the extracorporeal circuit were judged as such by an experienced ECMO-physician or ECMO-nurse
  2. ALT; alanine aminotransferase, AST; aspartate aminotransferase, CRP; C-reactive protein, eCPR; extracorporeal cardiopulmonary resuscitation, FiO; fraction of inspired oxygen, ICU; intensive care unit, PEEP; positive end-expiratory pressure, SOFA; sequential organ failure assessment score