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Fig. 7 | Journal of Translational Medicine

Fig. 7

From: Expression pattern analysis of m6A regulators reveals IGF2BP3 as a key modulator in osteoarthritis synovial macrophages

Fig. 7

IGF2BP3 was associated with OA synovial phenotypic changes. A Heatmap of two synovium sample clusters identified with function ConsensusClusterPlus based on IGF2BP3 and its targeting genes, C1 cluster contains 60 synovium samples and C2 cluster contains 53 synovium samples. B PCA reduction of C1 and C2 clusters. C Proportion of control and OA samples in C1 and C2 clusters. D IGF2BP3 expression in C1 and C2 clusters, with numbers on the top indicating P value. E ssGSEA scores of IGF2BP3 upreuglated/downregulated genes in C1 and C2 clusters, with number on the top indicating P value. F Volcano plot of DEGs in C1 and C2 clusters marked with macrophage (FCGR1A, FCGR1B), M1 macrophage (CD86, TLR2), and M2 macrophage (MRC1, IL-4) markers. Brown and blue points represent the genes with significantly upregulated or downregulated expressions in C2 synovium compared to C1 (FDR < 0.05 and absolute fold-change > 1.5). The two vertical dashed lines denote ± log2(1.5) fold-changes in gene expression, and the horizontal dashed line marks − log10(FDR adjusted p-value cutoff 0.05). G Top 5 enriched KEGG pathways of upregulated genes in C2 cluster compared to C1 cluster. H Top 5 enriched KEGG pathways of downregulated genes in C2 cluster compared to C1 cluster

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