Fig. 4

Functional network suggested potential role of core m6A regulators mediating OA synovitis. A Molecular network of core m6A regulators and their targeting genes analyzed by STRING database. Nodes in green, blue, pink, orange, yellow, and purple represent FTO-, HNRNPC-, IGF2BP3-, METTL5-, YTHDC1-, ZC3H13-regulated genes. B, C MCODE application identifying two hub gene networks of the whole molecular network. D Hallmark gene set enrichment of the whole molecular network based on 50 specific well-defined biological processes stored in the MSigDB database. Peripheral circle of the chord diagram indicates − log10 (FDR-pValue), and pathways of FDR-pValue < 0.05 were selected. E, F Hallmark gene set enrichment of the two hub gene networks. Peripheral circle of the chord diagram indicates − log10 (FDR-pValue), and pathways of FDR-pValue < 0.05 were selected