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Fig. 3 | Journal of Translational Medicine

Fig. 3

From: Expression pattern analysis of m6A regulators reveals IGF2BP3 as a key modulator in osteoarthritis synovial macrophages

Fig. 3

6 m6A regulators formed an effective prediction model of OA. A Partial likelihood deviance for LASSO-Cox regression. Lambda value of 0.0230 showed the minimum cross-validation error. B The coefficients of model genes were calculated to remove highly correlated genes and 6 m6A regulators (HNRNPC, IGF2BP3, YTHDC1, FTO, METTL5, ZC3H13) were identified by LASSO-Cox regression. C Heatmap of OA risk scores and m6A regulator expressions. OA risk scores of samples were sorted in ascending order. Samples whose risk scores ranked top 50% were called high-risk samples (indicated by red bar), while the remaining samples were referred to as low-risk samples (indicated by blue bar). D ROC curve for the OA prediction model based on the expression levels of these 6 m6A regulators in training set. E ROC curve based on single m6A regulator expression in OA training set

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