Fig. 4

The altered blood metabolites in the positive ion mode of the CPP group. A PLS-DA of CPP group and healthy controls. B The analysis of differences between groups recognized 1026 metabolites with significant differences and up-regulated and down-regulated metabolites with the top 20 largest differential degrees were marked. The outer circle colors of the dots indicated the different classifications of metabolites. C The abundance of 1026 metabolites. D The comparison of metabolites in primary bile acid biosynthesis pathways between two groups. E The enrichment analysis of KEGG metabolic pathways according to differential metabolites and the enrichment significances were computed by hypergeometric distribution. The size of the point represented the enriched metabolites in pathways and the color of the point represented the differential abundance scores (* p < 0.05). F The abundance of the shared metabolites in the fecal and blood