Table 2 Multivariate analysis of survival and contributing factors
Outcomes | Hazard ratio (95% CI) | P value |
|---|---|---|
OS | ||
 Matched sibling donor | reference | 0.45 |
 Haploidentical donor | 0.867 (0.597–1.260) |  |
 Other significant factors | ||
Age at HSCT (years) | ||
 < 40 | Reference | 0.02 |
 ≥ 40 | 1.511 (1.059–2.156) |  |
Refined disease risk index | ||
 Low-intermediate | Reference |  < 0.001 |
 High-very high | 2.176 (1.419–3.335) |  |
Remission status | ||
 First complete remission, MRD negative | Reference | 0.67 |
 First complete remission, MRD positive | 0.844 (0.536–1.328) | 0.46 |
 Second or third complete remission | 0.969 (0.544–1.727) | 0.92 |
 Active disease | 1.270 (0.716–2.251) | 0.41 |
Acute GVHD | ||
 0–II | Reference |  < 0.001 |
 III–IV | 2.810 (1.732–4.559) |  |
Chronic GVHD | ||
 None | Reference |  < 0.001 |
 Mild | 0.360 (0.220–0.588) |  < 0.001 |
 Moderate | 0.404 (0.176–0.929) | 0.03 |
 Severe | 1.388 (0.606–3.181) | 0.44 |
RFS | ||
 Matched sibling donor | Reference | 0.21 |
 Haploidentical donor | 0.808 (0.578–1.130) |  |
Other significant factors | ||
 Refined disease risk index |  |  |
  Low-intermediate | Reference |  < 0.001 |
  High-very high | 2.227 (1.530–3.242) |  |
Remission status | ||
 First complete remission, MRD negative | Reference | 0.71 |
 First complete remission, MRD positive | 1.066 (0.723–1.572) | 0.75 |
 Second or third complete remission | 1.148 (0.688–1.917) | 0.60 |
 Active disease | 1.342 (0.811–2.219) | 0.25 |
Acute GVHD | ||
 0–II | Reference | 0.004 |
 III–IV | 1.985 (1.252–3.148) |  |
Chronic GVHD | ||
 None | Reference | 0.003 |
 Mild | 0.532 (0.360–0.788) | 0.002 |
 Moderate | 0.555 (0.280–1.099) | 0.09 |
 Severe | 1.524 (0.709–3.277) | 0.28 |
NRM | ||
 Matched sibling donor | Reference | 0.58 |
 Haploidentical donor | 1.211 (0.618–2.736) |  |
Other significant factors | ||
Age at HSCT (years) | Â | 0.01 |
 < 40 | Reference |  |
 ≥ 40 | 2.160 (1.199–3.892) |  |
Refined disease risk index | ||
 Low-intermediate | Reference | 0.35 |
 High-very high | 1.476 (0.658–3.310) |  |
Remission status | ||
 First complete remission, MRD negative | Reference | 0.77 |
 First complete remission, MRD positive | 0.831 (0.400–1.726) | 0.62 |
 Second or third complete remission | 0.708 (0.241–2.079) | 0.53 |
 Active disease | 1.312 (0.488–3.524) | 0.59 |
Acute GVHD | ||
 0–II | Reference |  < 0.001 |
 III–IV | 6.679 (3.560–12.530) |  |
Chronic GVHD | ||
 None | Reference | 0.001 |
 Mild | 0.325 (0.137–0.772) | 0.01 |
 Moderate | 0.347 (0.082–1.473) | 0.15 |
 Severe | 3.860 (1.343–11.097) | 0.01 |