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Fig. 4 | Journal of Translational Medicine

Fig. 4

From: OSMR deficiency aggravates pressure overload-induced cardiac hypertrophy by modulating macrophages and OSM/LIFR/STAT3 signalling

Fig. 4

OSMR deficiency mediates inflammation and macrophage polarization in vivo. A Flow cytometric analysis of F4/80+ and LIFR+ cells in the heart tissue (n = 4 per experimental group). B Flow cytometric analysis of CD45+LIFR+Ly6C+ and CD45+LIFR+F4/80+ cells in mouse hearts at 4 weeks after sham or AB surgery (n = 4 per experimental group). C RT‒PCR analysis of TNF-α, MCP-1, CXCL1, VCAM1, P-selectin, IL-6, IL-1β, iNOS, Arg1 and IL-10 mRNA expression in mouse hearts at 4 weeks after sham or AB surgery (n = 6 per experimental group). mRNA expression was quantified and normalized to GAPDH (fold change). Data are presented as the mean ± SEM. *P < 0.05 compared with WT/Sham. #P < 0.05 compared with WT/AB

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