Fig. 2

OSMR deficiency exacerbates cardiac dysfunction and fibrotic remodelling in pressure-overloaded hearts. A Echocardiographic parameters and haemodynamic parameters of mice with or without OSMR knockdown at the indicated times (n = 8 mice per experimental group). B Representative images of picrosirius red (PSR) staining of transverse heart sections in each group (n = 8 per experimental group). (C-D) RT‒PCR analysis of ANP, BNP, α-MHC and β-MHC (C) and Col1, Col3, Ctgf and fibronectin (FN). D mRNA expression in mouse hearts at 4 weeks after sham or AB surgery (n = 6 per experimental group). mRNA expression was quantified and normalized to GAPDH (fold change). Data are presented as the mean ± SEM. *P < 0.05 compared with the matched control. #P < 0.05 compared with WT/AB