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Table 1 Clinicopathological characteristics of patients with samples subjected to multiplex staining

From: Functional status and spatial architecture of tumor-infiltrating CD8+ T cells are associated with lymph node metastases in non-small cell lung cancer

Characteristic

All patients

(N = 279)

Without LNM

(n = 193)

With LNM

(n = 86)

P value

Age, years

    

  ≤ 60

  > 60

  Median (IQR)

124 (44.4%)

155 (55.6%)

62 (57.67)

77 (39.9%)

116 (60.1%)

63 (58.68)

47 (54.7%)

39 (45.3%)

59 (53.65)

0.002

Gender

    

  Male

  Female

182 (65.2%)

97 (34.8%)

125 (64.8%)

68 (35.2%)

57 (66.3%)

29 (33.7%)

0.807

Smoking indexa

    

  < 400

  ≥ 400

156 (55.9%)

123 (44.1%)

109 (56.5%)

84 (43.5%)

47 (54.7%)

39 (45.3%)

0.777

ECOG PS

    

  0–1

  > 1

202 (72.4%)

77 (27.5%)

144 (74.6%)

49 (25.3%)

58 (67.4%)

28 (32.5%)

0.147

Tumor diameter (cm)

    

  Median (IQR)

3.0 (2.5, 4.0)

3.0 (2.5, 4.0)

3.5 (2.8, 4.7)

<0.001

Histological type

    

  LUSC

  LUAD

  Other

95 (34.1%)

179 (64.2%)

5 (1.8%)

61 (31.6%)

128 (66.3%)

4 (2.1%)

34 (39.5%)

51 (59.3%)

1 (1.2%)

0.180

T stage

    

  T1

  T2

  T3

  T4

88 (31.5%)

161 (57.7%)

16 (5.7%)

14 (5.0%)

73 (37.8%)

100 (51.8%)

11 (5.7%)

9 (4.7%)

15 (17.4%)

61 (70.9%)

5 (5.8%)

5 (5.8%)

0.004

N stage

    

  N0

  N1

  N2

  N3

193 (69.2%)

49 (17.6%)

37 (13.3%)

0 (0%)

193 (100.0%)

0 (0%)

0 (0%)

0 (0%)

0 (0%)

49 (57.0%)

37 (43.0%)

0 (0%)

<0.001

AJCC Stage

    

  IA

  IB

  IIA

  IIB

  IIIA

  IIIB

72 (25.8%)

83 (29.7%)

18 (6.5%)

52 (18.6%)

50 (17.9%)

4 (1.4%)

72 (37.3%)

83 (43.0%)

18 (9.3%)

10 (5.2%)

10 (5.2%)

0 (0%)

0 (0%)

0 (0%)

0 (0%)

42 (48.8%)

40 (46.5%)

4 (4.7%)

<0.001

  1. LUSC, lung squamous cell carcinoma; LUAD, lung adenocarcinoma; LNM, lymph node metastases; IQR, interquartile range
  2. a, Smoking index = number of cigarettes smoked per day × year(s)
  3. Bold values indicate the significantly different clinicopathological characteristics between patients with and without LNM, determined by Mann-Whitney U test