Fig. 5

Microvessels and fibroblasts were correlated with exclusion and dysfunction of CD8 + T cells. a Illustration of the calculation of the cancer-cell proximity score (CCPS). b Discrepancies of the CCPS of CD8 + T-cell functional subsets between patients with LNM and without LNM. c Forest plots of univariate and multivariate logistic models demonstrated the relationships between the CCPS of CD8 + T-cell functional subsets and LNM. ^a The multivariate logistic model adjusted age, gender, histology subtype and tumor diameter. d Correlation heatmap exhibited the relationships between the CCPS of stromal cells and T cells. Significance (P value) was determined by Spearman rank correlation analysis. * 0.01 ≤ P < 0.05, ** 0.001 ≤ P < 0.01, *** P < 0.001, NS, no significance. Discrepancies of the proximity of CMVs (e), CAFs (f) between hypoxic and normoxic cancer cells. Significance (P value) was determined by Mann–Whitney U test