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Fig. 1 | Journal of Translational Medicine

Fig. 1

From: LINC00963-FOSB-mediated transcription activation of UBE3C enhances radioresistance of breast cancer cells by inducing ubiquitination-dependent protein degradation of TP73

Fig. 1

UBE3C is upregulated in BRCA samples after radiotherapy. A analysis of network topology for various soft-thresholds (power) in the dataset; B heatmap for the correlation between the WGCNA gene clustering module and clinical traits; C correlation of black modules with clinical traits; D modules for each TCGA-WGCNA gene (each branch represents one gene); E expression of the top 10 DEG (TNFRSF21, GFI1B, KYNU, FABP5, HIF1A, HN1, UBE3C, TRIM47, PGK1, COBLL1) in TCGA-BRCA; F UBE3C expression in the GSE101920 dataset; G UBE3C expression in patients with or without response to radiotherapy in TCGA-BRCA; H, I, correlations between UBE3C expression and the clinical stage (H) and survival (I) of patients in TCGA-BRCA; J, K RT-qPCR and WB analyses for mRNA (J) and protein (K) levels of UBE3C in Pa and R MDA-MB-231 and SK-BR-3 cells. Data are expressed as the mean ± SD. Three repetitions were performed. Differences were analyzed by two-way ANOVA. **p < 0.01, ***p < 0.001

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Journal of Translational Medicine

ISSN: 1479-5876

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