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Fig. 2 | Journal of Translational Medicine

Fig. 2

From: SYTL2 promotes metastasis of prostate cancer cells by enhancing FSCN1-mediated pseudopodia formation and invasion

Fig. 2

SYTL2 promotes the mobility of PCa cells in vitro. A, B qRT‒PCR (A) and Western blot (B) analysis of SYTL2 expression levels in SYTL2 knockdown, overexpressing cells and control cells. C, D Representative images of migration (C) and invasion (D) assays using PC-3 and DU145 cells (left panels) and a quantification analysis of migrated or invaded cell counts (right panels), showing cell migration and invasion after downregulation or upregulation of SYTL2. E Representative images of wound-healing assays using PC-3 and DU145 cells showing cell motility after downregulation or upregulation of SYTL2. F Quantification analysis of the cell migration index is shown. G Representative images of three-dimensional (3D) cell culture using PC-3 and DU145 cells, showing the cell invasive ability in stereoscopic space. *p < 0.05, **p < 0.01 and ***p < 0.001. Scale bars: 25 μm (red)

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