Journal of Translational Medicine

Table 2 Top 10 PP2A-genes and EMT-genes in PDAC-datasets

From: Human pancreatic cancer patients with Epithelial-to-Mesenchymal Transition and an aggressive phenotype show a disturbed balance in Protein Phosphatase Type 2A expression and functionality

A: PP2A
Spearman correlation			Gene expression
Gene	SPmean	Median p ¹⁰log	Gene	meanDELTA	t-test Median p ¹⁰log
PPP2R1B	− 0.602	− 7.590	PPP2R1B	− 0.637	− 7.082
SETBP1	− 0.430	− 5.121	PPP2R2D	− 1.056	− 4.393
KIAA1524	0.518	− 4.539	SETBP1	− 0.652	− 4.327
PPME1	0.452	− 3.833	PPME1	0.279	− 3.971
ARPP19	0.465	− 3.342	KIAA1524	0.320	− 3.868
PPP2R2D	− 0.547	− 3.048	ARPP19	0.416	− 3.443
PPP2R2A	0.405	− 2.951	PPP2R5E	0.453	− 3.149
TIPRL	0.408	− 2.943	TIPRL	0.314	− 2.898
STRN	0.403	− 2.654	ANP32A	0.379	− 2.219
PPP2R5E	0.456	− 2.161	PPP2R2A	0.275	− 2.163

B: EMT
Spearman correlation			Gene expression
Gene	SPmean	Median p ¹⁰log	Gene	meanDELTA	t-test Median p ¹⁰log
KRT19	0.716	− 10.000	KRT19	2.113	− 9.064
TWIST1	0.615	− 10.000	TWIST1	1.658	− 7.562
HIF1A	0.512	− 8.423	HIF1A	0.675	− 7.010
LEF1	0.565	− 5.963	LEF1	1.172	− 6.648
MMP2	0.486	− 5.963	FGFR1	− 0.658	− 6.158
IRS1	0.635	− 5.842	YAP1	0.766	− 5.571
SNAI2	0.457	− 5.520	MMP2	0.828	− 4.946
YAP1	0.555	− 5.294	CTNNB1	0.405	− 4.582
FGFR1	− 0.579	− 5.121	IRS1	1.038	− 4.512
ZEB1	0.623	− 5.080	FZD7	0.949	− 4.414

For dataset GSE15471, GSE16515 and GSE101448, the Spearman correlation was computed, and from these the mean Spearman correlation (SPmean: tumor = 1 vs non-tumor = 0) for the A: PP2A genes and for the B: EMT genes. The median p-value was computed and expressed as ¹⁰log. Differential gene expression was also computed (tumor vs non-tumor as ²log values) and the mean was calculated (meanDELTA). A t-test was computed for the individual genes in each dataset followed by calculation of median p-value (¹⁰log)

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ISSN: 1479-5876

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