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Fig. 4 | Journal of Translational Medicine

Fig. 4

From: Human pancreatic cancer patients with Epithelial-to-Mesenchymal Transition and an aggressive phenotype show a disturbed balance in Protein Phosphatase Type 2A expression and functionality

Fig. 4

Clinical evaluation of PP2A-markers in Clinical Proteomic Tumor Analysis Consortium (CPTAC) samples and TCGA samples. A Protein expression of top PP2A genes identified in the GSE62165 patient samples. Log2 Spectral count ratio values from CPTAC were first normalized within each sample profile and then normalized across samples. Z-values represent standard deviations from the median across samples for the given cancer type. B Graphs showing protein expression for CIP2A and CDH1. C Gene expression in TCGA dataset, Log-rank graph for overall survival for KIAA1524/CIP2A of PDAC patients. D Survival analysis in patients. Log-rank overall survival analysis of TCGA dataset of PDAC patients for selected PP2A genes and CDH1 (representing EMT). (FPKM = Fragments Per Kilobase of transcript per Million mapped reads). (TCGA: access August 13, 2022 via https://www.proteinatlas.org/ENSG00000163507-CIP2A/pathology/pancreatic+cancer)

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