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Fig. 2 | Journal of Translational Medicine

Fig. 2

From: Human pancreatic cancer patients with Epithelial-to-Mesenchymal Transition and an aggressive phenotype show a disturbed balance in Protein Phosphatase Type 2A expression and functionality

Fig. 2

Correlation between PP2A genes and EMT genes in tumor vs. non-tumor pancreatic cancer (GSE101448). A Hierarchical clustering (HC) of gene expression for the PP2A genes was performed on tumor samples (T_xx) and non-tumor samples (N_xx). The samples were separated into two clusters indicated at the top; red (enriched for tumor) and blue (enriched for non-tumor) with a sensitivity of 79.2% and a specificity of 100%. The color scale illustrates the relative level of gene expression (Z-score): red, increased expression above the mean Z-score; green, reduced expression in tumor. B HC was performed using the EMT gene expression, which also resulted in two clusters; red (enriched for tumor) and blue (enriched for non-tumor) with a sensitivity of 100% and a specificity of 84.2%. C The Spearman correlation was computed for each gene in the PP2A gene list to each of the EMT genes. These correlations are visualized in an HC-graph showing distinct clustering. To make a distinction with gene expression, the Spearman correlation is indicated with a color scale ranging from yellow to pink; clusters indicate genes that are co-regulated in PDAC

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