Fig. 1

A The primary components of IH. The major components of IH include HemSCs, HemECs and Hempericytes. In the proliferative stage of IH, HemSCs are mainly differentiated into HemECs and Hempericytes to promote angiogenesis. In the phase of IH regression, adipocytes and fibrocytes were mainly differentiated. B Model of cell suspension implantation. Cell suspension injection has become the most commonly used method for IH model construction. HemSCs, HemSCs and MMS, HemSCs and HUVECs, HemECs, HemECs and Hempericytes were mixed with matrix gel with syringe implantation to prepare cell suspensions. Then, they were injected subcutaneously into the back of nude mice. The implanted cells proliferated and differentiated to form local hemangiomatous masses