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Table 1 Basic information of control subjects and ACS patients

From: MiR-146a rs2910164 (G/C) polymorphism is associated with the development and prognosis of acute coronary syndromes: an observational study including case control and validation cohort

 

Control (n = 552)

ACS (n = 619)

P value

Age, y

56.67 ± 10.87

58.45 ± 10.96

0.006

Male, n (%)

272 (49.3)

340 (54.9)

0.053

Smoking, n (%)

170(30.8)

225(36.3)

0.045

Drinking, n (%)

112(20.3)

123(19.9)

0.858

Hypertension, n (%)

270(48.9)

342(55.3)

0.030

Diabetes mellitus, n (%)

124(22.5)

168(27.1)

0.065

Family history, n (%)

90(16.3)

134(21.5)

0.020

BMI, kg/m2

24.80 ± 3.43

25.16 ± 3.10

0.063

SBP, mmHg

126.82 ± 19.60

124.74 ± 21.57

0.084

DBP, mmHg

79.28 ± 13.00

77.98 ± 13.56

0.096

Heart rate, bmp

73.63 ± 10.14

74.83 ± 15.04

0.107

LVEF, %

56.60 ± 8.88

55.25 ± 11.04

0.021

Creatinine, mg/dl

79.09 ± 16.48

81.42 ± 22.06

0.042

FBG, mmol/l

6.42 ± 1.45

6.72 ± 1.91

0.002

CK, U/l(IQR)

73.65(58.88)

91.50(80.20)

 < 0.001

CK-MB, U/l(IQR)

11.60(5.58)

13.50(10.50)

 < 0.001

FIB, g/l

3.05 ± 1.15

3.72 ± 1.14

 < 0.001

D-Dimer, mg/l(IQR)

0.56(0.84)

0.85(0.70)

 < 0.001

FDP, mg/l

3.04 ± 1.15

3.72 ± 1.72

 < 0.001

CRP, μg/ml

2.75 ± 0.92

6.47 ± 2.94

 < 0.001

BNP, ng/l(IQR)

124.99(193.56)

418.87(961.20)

 < 0.001

TC, mmol/l

3.82 ± 0.77

4.01 ± 1.07

 < 0.001

TG, mmol/l

1.87 ± 0.86

1.93 ± 0.80

0.282

HDLC, mmol/l

1.01 ± 0.16

0.99 ± 0.23

0.030

LDLC, mmol/l

2.24 ± 0.77

2.38 ± 0.91

0.004

ApoA1, g/l

1.01 ± 0.20

1.02 ± 0.20

0.425

ApoB, g/l

0.76 ± 0.24

0.79 ± 0.24

0.113

ApoE, g/l

35.89 ± 12.57

36.85 ± 14.40

0.230

Lpa, mg/dl

196.32 ± 69.37

207.00 ± 99.72

0.032

Hb, g/l

136.25 ± 16.81

138.27 ± 17.39

0.044

WBC, 109 /l

6.01 ± 2.47

9.00 ± 4.43

 < 0.001

ACEI, %

308(55.8)

364(58.8)

0.299

β-blocker, %

430(77.9)

509(82.2)

0.063

Statin, %

476(86.2)

555(89.7)

0.071

Aspirin, %

519(94.0)

595(96.1)

0.095

CCB, %

153(27.7)

407(65.8)

 < 0.001

  1. BMI body mass index; SBP systolic blood pressure; DBP diastolic blood pressure; LVEF left ventricular ejection fraction; FBG fasting blood glucose; CK creatine kinase; CK-MB creatine kinase isoenzymes; FIB fibrinogen; FDP fructose-1, 6-diphosphate; CRP C-reactive protein; BNP brain natriuretic peptide; TC total cholesterol; TG: triglyceride; HDL high-density lipoprotein cholesterol; LDL low-density lipoprotein cholesterol; Apo Apolipoprotein; Lpa lipoprotein a; HGB hemoglobin; WBC white blood cell count; ACEI angiotensin converting enzyme inhibitor; ARB angiotensin receptor blocker; CCB calcium channel blocker