Fig. 4
From: A dominant variant in apoptosis-related gene XKR8 is relevant to hereditary auditory neuropathy
Hearing loss in the XKR8+/− mouse model. Compared with WT mice, XKR8+/− mice showed hearing loss from the age of 12 weeks (A) but had intact hair cell function at 20 weeks of age (B). Representative results showed scattered XKR8-positive plaques in the mouse cochlea at 20 weeks of age (C and D). Truncated XKR8 was localized in regions beneath inner hair cells (white arrows in D). *p < 0.05, **p < 0.01 (indicating different hearing results between the two groups). Scale bars: C, 500 μm; D, 25 μm