Fig. 6

NP analysis for ICA in AD treatment. A Venn diagram of the ICA and AD target genes. B Analysis of the ICA and AD hub genes. C PPI network for ICA in AD treatment. The nodes represent functional proteins, the edges represent the interactions between the proteins, and the size and hue of the circles indicate the significance of the proteins. D KEGG enrichment analysis of the potential AD-associated ICA targets. The size of the dots represents the number of genes engaged in the pathway and the color represents the adjusted p-value. E Network of interactions between AD, icariin, targets, and pathways, in which red represents AD, blue represents icariin, green represents putative protein targets, and yellow represents the pathway. NP, network pharmacology; ICA, icariin; AD, Alzheimer's disease; PPI, protein–protein interaction; KEGG, Kyoto Encyclopedia of Genes and Genomes