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Fig. 3 | Journal of Translational Medicine

Fig. 3

From: Preventative effect of TSPO ligands on mixed antibody-mediated rejection through a Mitochondria-mediated metabolic disorder

Fig. 3

The TSPO ligands FGIN1-27 and Ro5-4864 inhibit donor-specific IgG secretion in vivo. The recipients (Lewis rats) after skin transplantation were divided into three groups, FGIN1-27, Ro5-4864, and control, who were administered FGIN1-27 (1 mg/kg), Ro5-4864 (1 mg/kg), or an equal volume of physiologic (0.9%) saline, respectively by gavage every day for 36 days. Sera from the orbit of recipient rats were collected and incubated with donor spleen cells. Levels of donor-specific IgG and IgM were measured by flow cytometry. A Experimental protocol of skin transplantation. B, C Circulating DSA levels were determined as the mean fluorescence intensity (MFI) ± SD (n = 5). *P < 0.05; **P < 0.01; ***P < 0.001

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