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Fig. 7 | Journal of Translational Medicine

Fig. 7

From: Circular RNA EPHA3 suppresses progression and metastasis in prostate cancer through the miR-513a-3p/BMP2 axis

Fig. 7

CircEPHA3 prevents tumor growth and metastasis in vivo. A The subcutaneously xenograft tumors formed by circEPHA3-overexpressed or vector PCa cells in BALB/c nude mice. B, C The tumor volume and weight of circEPHA3-overexpressed and vector PCa groups. D The expression of BMP2 protein in circEPHA3-overexpressed and vector PCa groups was assessed by IHC analysis. The red scale bars = 100 μm, the black scar bars = 20 μm. E Representative images of bioluminescence in both metastasis groups captured by IVIS 100 Imaging System. F Representative images of H&E of the lungs in circEPHA3-overexpressed and vector PCa groups. The red scale bars = 500 μm, the black scar bars = 20 μm. *, ** and *** represented P < 0.05, 0.01 and 0.001, respectively

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