Fig. 2

CircEPHA3 prevents the progression of PCa in vitro. A, B Relative expression of circEPHA3 and EPHA3 mRNA in PCa cells transfected with circEPHA3 or vector lentivirus. C The proliferative capacity of circEPHA3-overexpressed or vector PC-3 and DU145 cells was measured by CCK-8. D, E The migratory capacity of circEPHA3-overexpressed or vector PC-3 and DU145 cells was evaluated by wound healing assays. Scale bars = 100 μm. F, G The migration and invasion capabilities of circEPHA3-overexpressed or vector PC-3 and DU145 cells were assessed by transwell migration and invasion assays. Scale bars = 100 μm. *, ** and *** represented P < 0.05, 0.01 and 0.001, respectively