Fig. 2

Alternation in the expression of USP37 leads to activation and repression of a distinct set of genes involved in different pathways: Whole cell RNA sequencing of U2OS cells before and after USP37 overexpression and Knock down. A The Heat map representation of all 3 phenotypes (WT or untreated, OE and KO) along with RNA type and chromosomal position of the DEGs with the ± 1.301 log₂ fold change cut off. B Histogram showing the distribution of DEGs in 3 phenotypes (i)OE vs WT, (ii)KD vs WT and (iii)OE vs KD. C Volcano plots of the DEG in 3 different phenotypes with ± 1.301 log₂ cut off. Distribution of RNA/genes vis whole RNA sequencing of U2OS cells after USP37 Overexpression and Knock down. D The Venn diagram shows the ± 2 Log₂ fold statistically significant genes/RNA of U2OS cells as compared to untreated cells after USP37 overexpression and Knock down. E In addition, the Heat map shows the comparison of statistically significant genes found in both USP37 overexpression and KO phenotypes when compared to untreated cells