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Fig. 8 | Journal of Translational Medicine

Fig. 8

From: Neuropilin-1 promotes mitochondrial structural repair and functional recovery in rats with cerebral ischemia

Fig. 8

The attenuated OGD-induced apoptosis in cultured primary cortical neurons by NRP-1 overexpression via the Wnt/β-catenin signaling pathway. A Representative immunoblots and Western Blot analysis of Wnt1; n = 4. Data are expressed as mean ± SEM. and analyzed by one-way analysis of ANOVA with Bonferroni’s post hoc test. ***p < 0.001, as compared with the Cont group; ##p < 0.01, as compared with the OGD/R group. B Representative immunoblots and C Western Blot analysis of APC, D Axin, E p-GSK-3β, F GSK-3β, G β-catenin in the cytoplasm and H β-catenin in the nucleus of different groups; n = 4. Data are expressed as mean ± SEM. and analyzed by one-way analysis of ANOVA with Bonferroni’s post hoc test. **p < 0.01, ***p < 0.001, as compared with the Cont group; #p < 0.05, ##p < 0.01, ###p < 0.001, as compared with the OGD/R group; &p < 0.05, &&p < 0.01, as compared with the OGD/R + LV-NRP-1 group. I Representative immunofluorescence image of p-β-catenin (Ser37) in cultured neurons of different groups. Scale bar: 20 μm. J–K The apoptosis of cultured neurons in different groups by flow cytometry; n = 3. Data are expressed as mean ± SEM. and analyzed by one-way analysis of ANOVA with Bonferroni’s post hoc test. ***p < 0.001, as compared with the Cont group; ###p < 0.001, as compared with the OGD/R group; &p < 0.05, as compared with the OGD/R + LV-NRP-1 group. (Cont = Control)

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