Fig. 7

The effect of NRP-1 overexpression on protein expression in tMCAO lesions following administration of XAV-939. A Representative immunoblots and B Western Blot analysis of Wnt1, C Wnt3α, D p-β-catenin, E β-catenin, F C-Myc, G CyclinD1, H Cytosolic Cyt c, I mitochondrial Cyt c, J Nuclear AIF, K Bcl-2 in the penumbra region of different groups; n = 4. Data are expressed as mean ± SEM. and analyzed by one-way analysis of ANOVA with Bonferroni’s post hoc test. *p < 0.05, **p < 0.01, ***p < 0.001, as compared with the Sham group; ^#p < 0.05, ^###p < 0.001, as compared with the tMCAO group; ^&p < 0.05, ^&&p < 0.01, as compared with the tMCAO + AAV-NRP-1 group. (L) Representative immunofluorescence image of β-catenin in the penumbra region of different groups. Scale bar: 50 μm