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Fig. 7 | Journal of Translational Medicine

Fig. 7

From: Disheveled3 enhanced EMT and cancer stem-like cells properties via Wnt/β-catenin/c-Myc/SOX2 pathway in colorectal cancer

Fig. 7

Silencing DVL3 inhibited tumorigenicity and metastasis of CRC cells in vivo. A For tumor xenograft assay in vivo, HCT-8 cells stably expressing LV-shDVL3 or LV-shNC were injected subcutaneously into nude mice. The representative images of tumor xenografts are shown. B Tumor growth curves of tumors in nude mice injected with HCT-8 cells stably expressing LV-shDVL3 or LV-shNC. Once the tumors became palpable, tumor volumes were measured with Vernier calipers every two days. C After the nude mice were killed, tumors xenograft were excised and weighed. D Tumors of LV-shDVL3 group formed at an earlier time point and developed at a faster rate than those of LV-shNC group. E The expression of SOX2, c-Myc, E-cadherin, N-cadherin and DVL3 were determined by western blotting in tumor xenograft with LV-shDVL3 or LV-shNC. F Representative images of lung metastasis and G H&E staining of metastatic tumors in nude mice injected with HCT-8 cells stably expressing LV-shDVL3 or LV-shNC via tail vein. H The statistical data of lung metastasis that developed in the mouse model. *P ≤ 0.05

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