Fig. 3

DVL3 was involved in TGF-β-induced EMT. Transwell assay showed the potential migration and invasion of HCT-8 (A) and SW620 (B) cells treated with TGF-β1 for 72 h, or transfected with shNC plus TGF-β1, or shDVL3 plus TGF-β1 for 72 h, as indicated. And then, western blotting was used to analyze the expressions of Snail, E-cadherin, ZO-1, N-cadherin, Vimentin and DVL3 in HCT-8 (C) and SW620 (D) cells transfected with shNC, shNC plus TGF-β1, or shDVL3 plus TGF-β for 72 h, as indicated. *P ≤ 0.05