Fig. 2

DVL3 enhanced metastatic potential of CRC cells. Transwell assays were used to determine the potential migration and invasion of HCT-8 (A) and SW620 (B) cells transfected with pcDNA3.1, pcDNA3.1-DVL3, shNC or shDVL3 for 72 h. C, D The transfection efficiency were confirmed by western blotting. The expressions of E-cadherin and ZO-1, N-cadherin and Vimentin were detected by western blotting in HCT-8 (E) and SW620 (F) cells transfected with pcDNA3.1 or pcDNA3.1-DVL3 for 72 h, as well as in HCT-8 (G) and SW620 (H) cells transfected with shNC or shDVL3 for 72 h. *P ≤ 0.05