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Fig. 1 | Journal of Translational Medicine

Fig. 1

From: Comprehensive single-cell transcriptomic and proteomic analysis reveals NK cell exhaustion and unique tumor cell evolutionary trajectory in non-keratinizing nasopharyngeal carcinoma

Fig. 1

NK-NPC proteomics results. A Volcano plot of differentially expressed proteins (DE-proteins). There are 76 proteins upregulated and 85 proteins downregulated in the NK-NPC group compared to the normal group, where proteins with fold change of log2foldchange > 0.5 and P value < 0.05 were defined as differentially expressed proteins. B The differentially expressed proteins between the 3 NK-NPC and 3 normal nasopharyngeal tissues were well distinguished using Principal Component Analysis (PCA). C KEGG enrichment analysis was performed on 161 differentially expressed proteins. D Protein heatmap showed that the DE-proteins enriched in the nature killer cell mediated cytotoxicity pathway were significantly downregulated in the NK-NPC group, including PRKCB, PTPN11, LCK, ITGAL, PIK3CB, CASP3 and MAPK3. E Representative images of immunohistochemical staining of B2M protein in the normal group and the NK-NPC group. F Representative images of immunohistochemical staining of CD56 and granzyme B in the normal group and the NK-NPC group

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