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Fig. 1 | Journal of Translational Medicine

Fig. 1

From: Protectin conjugates in tissue regeneration 1 alleviates sepsis-induced acute lung injury by inhibiting ferroptosis

Fig. 1

Ferroptosis is induced in LPS-induced ALI and associated with lung damage. LPS (15 mg/kg) in saline or an equivalent volume of saline was intraperitoneally injected into mice, and lung tissues were collected at 0, 12, 24, and 48 h, respectively. A–C Representative western blotting and quantification analysis of GPX4 and PTGS2. D–F Relative values of Fe2+, GSH and MDA concentrations. Mice were pretreated with ferrostatin-1 (10 mg/kg, ip) 1h1 h before being injected with LPS (15 mg/kg, ip). Lung samples were collected 24 h after LPS injection. G Representative H&E staining of lung tissues (original magnification, ×200; inset, ×400). H Acute lung injury score of each group. I–K The relative mRNA expression levels of the inflammatory cytokines: IL-6, TNF-α and IL-1β. The acute lung injury score data are presented as the median and range (25th–75th percentile), and other data are presented as the mean ± SD. n = 4–6. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 and ns: p > 0.05. ip: intraperitoneal

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