Table 2 Genetic correlation estimates for IBS and neuroticism, depression and anxiety using Linkage Disequilibrium Score Regression (LDSC)
Trait 1 | Trait 2 | Genetic Correlation | SE | Z | P-value | Intercept (SE) | Trait 1 | Trait 2 |
|---|---|---|---|---|---|---|---|---|
h2 (SE) | h2 (SE) | |||||||
IBS | Neuroticism | 0.526 | 0.027 | 19.298 | 5.54E-83 | 1.013 (0.013) | 0.069 (0.004) | 0.146 (0.005) |
IBS | Depression | 0.587 | 0.026 | 22.714 | 3.23E-114 | 0.992 (0.01) | 0.069 (0.004) | 0.099 (0.004) |
IBS | Anxiety | 0.677 | 0.065 | 10.360 | 3.75E-25 | 0.999 (0.74) | 0.068 (0.004) | 0.083 (0.011) |