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Table 1 Summary of the GWAS datasets used in the current study

From: Genome-wide multi-trait analysis of irritable bowel syndrome and related mental conditions identifies 38 new independent variants

Phenotype

N cases

N controls

N total

N effective a

GWAS genome-wide significant SNPsb

References

IBS

53,400

433,201

486,601

190,159

6

[18]

Neuroticism

–

–

390,278c

390,278

136d

[20]

Depression

170,756

329,443

500,199c

449,856

102d

[21]

Anxiety nerves or GAD

16,730

101,021

117,751

57,412

1

UKBB phenotype code: 20544_15

  1. GAD generalized anxiety disorder; UKBB UK Biobank
  2. aN effective sample sizes were calculated following the equation: Neff = 4/(1/Ncases + 1/Ncontrols)
  3. bNumber of genome-wide significant independent SNPs
  4. cSample size excluding the 23andMe cohort
  5. dGenome-wide significant SNPs including the 23andMe cohort