Fig. 9

ROC analysis of the mutations in LUAD and control plasma cfDNA samples in the training data set. ROC analysis for the mutations of the nuclear genome in LUAD and control plasma cfDNA samples in the A training data set and B testing data set. ROC analysis for the mitochondrial genome mutations in LUAD and control plasma cfDNA samples in the C training data set and D testing data set. TT, the selected genes whose mutations were associated with higher TMB in tumor tissues; CFT, the selected genes that had mutations were associated with higher TMB in cfDNA of LUAD patients; HC, the selected genes whose variation frequencies in tumor tissues and cfDNA were both > 25%. THF: the top five mutated genes in tumor tissues; CFHF: the top five mutated genes in cfDNA of LUAD patients; ALL: all the above-selected genes