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Fig. 6 | Journal of Translational Medicine

Fig. 6

From: Molecular fingerprints of nuclear genome and mitochondrial genome for early diagnosis of lung adenocarcinoma

Fig. 6

Concordance of mutation calls between solid and liquid biopsies. A Heatmap displayed the VAFs for mutations in selected genes of the nuclear genome. For each gene, maximum VAF was provided for 29 tumor tissues, their adjacent tissues, and plasma cfDNA samples. B Correlation of somatic mutation maximum VAFs of the nuclear genome in paired tumor tissue and cfDNA samples. Density estimates demonstrated a peak in mutations detected exclusively in one gene. The p-value was calculated using linear regression. C Donut chart showing the VAFs for mutations in selected genes of the mitochondrial genome. For each gene, maximum VAFs were provided for 10 tumor tissues, their adjacent tissues, and plasma cfDNA samples. The outer circle illustrated whether the 10 tumor tissues harbored mutations in relevant genes. The inner circle showed whether the ten plasma samples harbored mutations in relevant genes. D Correlation of somatic mutation maximum VAFs of the mitochondrial genome in paired tumor tissue and cfDNA samples. Density estimates displayed a peak in mutations detected exclusively in one gene. The p-value was calculated using linear regression. E Bar plot illustrating ctDNA fraction of mitochondrial genome in solid and liquid biopsies

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